ION Breast Cancer Clinical Pathways - ION Solutions

Adjuvant Non-Small Cell Lung (NSCL)Chemotherapy:Platinol (Cisplatin) Navelbine (Vinorelbine) EP=High; FN=10%-20%Cisplatin 100mg/m 2 D1 (or D1, D8 protocol equivalent)Vinorelbine 30mg/m 2 D1, D8, D15, D22q 28 Day Cycle x 4 Cycles>> N Engl J Med 352:2589-2597, 2005>> N Engl J Med 350:351-360, 2004>> Lancet Oncol 7:71+-727, 2006Platinol (Cisplatin) Gemzar (Gemcitabine) EP=High; FN> Ann Oncol 18:317-323, 2007>> N Engl J Med 346:92-98, 2002Platinol (Cisplatin) Taxotere (Docetaxel) EP=High; FN=10%-20%Cisplatin 75mg/m 2 D1Docetaxel 75mg/m 2 D1q 21 Day Cycle x 4 Cycles>> J Clin Oncol 21:3016-3024, 2003 Epub 2003 Jul 1Platinol (Cisplatin) Alimta (Pemetrexed) EP=High; FN> J Clin Oncol 29: 2011 (suppl; abstr 7002)Taxol (Paclitaxel) Paraplatin (Carboplatin) EP=Moderate; FN=10%-20%Paclitaxel 200mg/m 2 D1Carboplatin AUC 6 D1q 21 Day Cycle x 4 Cycles>> J Clin Oncol 26:5043-5051, 2008Platinol (Cisplatin) Taxol (Paclitaxel) EP=High; FN˃20%Cisplatin 75mg/m2 D1Paclitaxel 200mg/m2 D1q 21 Day Cycle x 4 Cycles>> NEnglJMed2002Jan10;346(2):92-8>> JClinOncol2008Nov1;26(31):5043-51Clinical Trial:Screen patient for clinical trial. Check www.clinicaltrials.gov for available trials.Best Supportive Care and/or Hospice:Consider supportive care options and Hospice when appropriate.Page 24 of 39© 2013 by ION Solutions. All rights reserved