Dr. Frances Shepherd CV - (NCRI) is

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of age on treatment selection and efficacy for stage III non-small cell lung cancer (NSCLC). American Society of Clinical Oncology (ASCO) Annual Meeting, Chicago. J Clin Oncol 28(15 Suppl): 7014, 2010. 64. Brade A, Bezjak A, MacRae R, Laurie S, Cho J, Hope A, Sun A, Wang L, Capobianco S, Iscoe N, Shepherd F. A phase II study of concurrent pemetrexed (P)/ cisplatin (C)/ radiation (RT) for unresectable stage IIIA/B non-small cell lung cancer (NSCLC). Canadian Association of Radiation Oncology (CARO) Annual Meeting, Vancouver. Radiother Oncol 96(Supp 2): S19, A56, 2010. 65. Giuliani M, Sun A, Bezjak A, Le L, Brade A, Cho J, Leighl N, Shepherd F, Hope A. Patterns of failure in patients with limited-stage small cell lung carcinoma. Canadian Association of Radiation Oncology (CARO) Annual Meeting, Vancouver. Radiother Oncol 96(Supp 2): S59, A182, 2010. 66. Giuliani ME, Lindsay PE, Sun A, Bezjak A, Le LW, Brade A, Cho J, Leighl N, Shepherd FA, Hope AJ. Patterns of failure in patients with limited-stage small cell lung carcinoma. American Society of Radiation Oncology (ASTRO) Annual Meeting, San Diego. Int J Radiat Oncol Biol Phys 78(Supp 3): S495, A2652, 2010. 67. Hope AJ, Coate LE, Massey C, Sacher A, Barrett K, Keshavjee S, Darling G, Leighl NB, Bezjak A, Shepherd FA. Outcomes of bimodality and trimodality therapy in patients with stage III non-small cell lung cancer (NSCLC). American Society of Radiation Oncology (ASTRO) Annual Meeting, San Diego. Int J Radiat Oncol Biol Phys 78(Supp 3): S505, A2673, 2010. 68. Cuffe S, Ezzalfani M, Graziano S, Pignon J, Seymour L, Strevel E, Burkes R, Shepherd FA. A Pooled Exploratory Analysis of the Effect of tumor Size on Survival benefits from Adjuvant Platinum-based Chemotherapy (ACT) in Node Negative (N0) Non-small Cell Lung Cancer (NSCLC). Presented at the Chicago Multidsiciplinary Symposium in Thoracic Oncology. Chicago 2010 J Thorac Oncol. S512. 69. Guiliani ME, Lindsay PE, Brade AM, Sun A, Bezjak A, Le LW, Cho J, Leighl N, Shepherd FA, Hope AJ. Outcomes of Salvage Therapy in Patients with Limited-Stage Small Cell Lung Carcinoma with Isolated Locoregional Failure. Presented at the Chicago Multidsiciplinary Symposium in Thoracic Oncology. Chicago 2010 J Thorac Oncol. S550 70. Ellis PM, Zhang J, Jones M, Jungnelius U, Shepherd FA. A Phae I Study of Pomalidamide (CC-4047) in Combonation with Cisplatin and Etoposide in Patients with Extensive Stage Small cell Lung Cancer (ES-SCLC). Presented at the Chicago Multidsiciplinary Symposium in Thoracic Oncology. Chicago 2010 J Thorac Oncol. S551. 71. Addison L, Ding K, Zhao H, Le Maitre A, Laurie SA, Goss G, Shepherd FA, Bradbusry PA, Seymour L. Angiogenic factors and soluble receptors in NCIC CTG BR.24. J Clin Oncol 29: 2011 (supp; abstr 3047) 72. Jotte R, Von Pawel J, Spigel DR, Socinscki MA,O’Brien M, Paschold EH , Mezger J, Steins M, Bosquee L, Bubis JA, Nackaerts K, Trigo Perez JM, Clingan PR, Schuette W, Lorigan P, Reck M, Domine M, Shepherd FA, McNally R, Renschler MF. Randomized phase III trial of amrubicin versus topotecan (Topo) as second-line treatment for small cell lung cancer (SCLC). J Clin Oncol 29: 2011 (supp; abstr 7000). 73. Michiels S, Mauguen A, Fisher D, Burdett S, Paulus R, Mandrekar SJ, Belani CP, Shepherd FA, et al. Evaluation of disease-free survival as surrogate endpoint for overall survival using two individual patient data meta-analyses of adjuvant chemotherapy in operable non-small cell lung cancer. J Clin Oncol 29: 2011 (supp; abstr 7004) 74. Cuffe S, Booth CM, Peng Y, Darling GE, Li G, Kong W, Mackillop WJ, Shepherd FA. Adoption of adjuvant chemotherapy (ACT) for non-small cell lung cancer (NSCLC) in 22
the elderly: A population-based outcomes study. J Clin Oncol 29: 2011 (supp; abstr 7012). 75. Spigel DR, Harper PA, Hainsworth JD, De Marinis F, Kabbinavar FF, Kim ES, Lynch TJ, Rosell R, Shepherd FA, Socincki MA. Randomized phase III trial of gemcitabine/carboplatin with or withour iniparib (BSI-201) in patients with previously untreated stage IV squamous non-small cell lung cancer (NSCLC). J Clin Oncol 29: 2011 (supp; abstr TPS220). 76. Hilton JF, Seymour L, Le Maitre A, Tu D, Shepherd FA, Bradbury PA. An evaluation of the possible interaction of gastric acid suppressive medication and the EGFR tyrosine kinase inhibitor erlotinib. J Clin Oncol 29: 2011 (supp; abstr 7523). 77. Sulpher JA, Owen SP, Hon H, Tobros K, Shepherd FA, et al. Factors influencing a specific histological diagnosis of non-small cell lung cancer. J Clin Oncol 29: 2011 (supp; abstr 7541). 78. Soulieres D, Wold J, Shepherd FA, et al. Meta-analysis of the predictive and prognostic value of erlotinib-related biomarkers in phase III, placebo-controlled trials in non-small cell lung cancer (NSCLC): Reccomendations of the BioLOGUE advisors. J Clin Oncol 29: 2011 (supp; abstr 7533). 79. Pintille M, Sykes J, Jurisica I, Shepherd FA, Tsao MS. Comparison of different strategies for finding clinically useful signatures. Proc 32 nd Annual Conference of the International Society for Clinical Biostatistics. Ottawa. 21-25 August 2011. P. 119 80. Booth CM, Shepherd FA, Peng Y, Darling GE, Li G, Kong W, Mackillop WJ. Adoption of adjuvant chemotherapy for non-small cell lung cancer: a population-based outcomes study. Presented at ASCO, Chicago, Il, June 2011. 81. Cuffe S, Graziano S, Abderrahmane B, Pignon JP on behalf of the LACE BIO Group, Ezzalfani M, Seymour, L, Strevel E, Burkes R, Capelletti M, Janne P, Tsao MS, Shepherd FA. A pooled exploratory anaylysis of the impact of tumour size and KRAS mutations on survival benefit from adjuvant platinum-based chemotherapy (ACT) in node negative (NO) non-small cell lung cancer. Presented at the IASLC 14 th World Conference on Lung Cancer, Amsterdam June 2011. J Thorac Oncol 2011; 6: S5462-63 82. Cuffe S, Booth C, Peng Y, Darling G, Li G, Kong W, Mackillop WJ, Shepherd FA. Uptake of adjuvant chemotherapy, its tolerability and impact on survival among elderly non-small cell lung cancer patients in Ontario: a population-based outcomes study. Presented at the IASLC 14 th World Conference on Lung Cancer, Amsterdam June 2011. J Thorac Oncol 2011; 6: S5463-64 83. Mauguen A, Michiels S, Burdett S, Tierney JF, Sause W, Mandrekar SJ, Dahlberg SE, Shepherd FA, PArmar M, Perry MC, O’Brien M, Le Pechoux C, Pignon J-P, On behalf of the Surrogate Project Collaborative Group. Evaluation of progression-free survival as a suurogate endpoint for overall survival when evaluating the effect of chemotherapy and radiotherapy in locally advanced lung cancer using data from four individual patient data meta-analyses. Presented at the IASLC 14 th World Conference on Lung Cancer, Amsterdam June 2011. J Thorac Oncol 2011; 6: S5464-65. 84. Novello S, Ramlau R, Gorbunova VA, Ciuleanu TE, Ozguroglu M, Goksel T, Baldotto C, Bennoune J, Shepherd FA, Scagliotti G. Alfibercept in combination with docetaxel for second-line treatment of locally advanced or metastatic non-small cell lung cancer (NSCLC): Final results of multinational placebo-controlled phase III trial (EFC10261- VITAL). Presented at the IASLC 14 th World Conference on Lung Cancer, Amsterdam June 2011. J Thorac Oncol 2011; 6: S570. 85. Yanagawa N, Saieg MA, Kohler D, Sykes J, John T, Santod GDC, Pintile M, Shepherd FA, Tsao MS. Apmlification of MYC abd aberrant expression of P53 and PTEN are predictive of ability to form primary tumor zenografts in resected non-small cell lung 23
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