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Dr. Frances Shepherd CV - (NCRI) is

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2012 Royal College of Physicians and Surgeons of Canada Whiteman Award and V<strong>is</strong>iting<br />

Professorship<br />

2012 Queen Elizabeth II Jubilee medal<br />

10. RESEARCH GRANT SUPPORT LAST 5 YEARS: (Peer-reviewed, non-industry grants<br />

shaded in gray)<br />

RESEARCH AREA<br />

Genomic and Proteomic biomarkers<br />

of response to treatment with small<br />

molecule Epidermal Growth Receptor<br />

Inhibitors in non-small cell lung<br />

cancer<br />

Translating the results of clinical<br />

trials of radio/chemotherapy into<br />

improved health outcomes in the<br />

general population<br />

Phase III trial of Taxotere versus<br />

Iressa as second-line chemotherapy<br />

for non-small cell lung cancer<br />

INTEREST<br />

National Cancer Institute of Canada<br />

Clinical Trials Group<br />

Genomic biomarkers of response to<br />

treatment with erlotinib, a small<br />

molecule tyrosine kinase inhibitor of<br />

the epidermal growth factor receptor<br />

inhibitor in NSCLC<br />

A Phase randomized II trial of<br />

ZD6474 or placebo in responding to<br />

patients with SCLC<br />

National Cancer Institute of Canada<br />

Clinical Trials Group<br />

Phase III trial of Tarceva in 3 rd -line<br />

treatment of NSCLC<br />

Phase III trial of Taxotere +/-<br />

Topotecan in 2 nd -line NSCLC<br />

ROLE<br />

GRANTING<br />

AGENCY<br />

Co-investigator OCRN<br />

(03-APR-0324)<br />

Co-Investigator OCRN<br />

(02-NOV-0266)<br />

Local<br />

Principal<br />

Investigator<br />

<strong>Dr</strong>. Pater PI,<br />

<strong>Dr</strong>. <strong>Shepherd</strong><br />

PI for Lung<br />

Site<br />

Principal<br />

Investigator<br />

Local<br />

Principal<br />

Investigator<br />

<strong>Dr</strong>. Pater PI,<br />

<strong>Dr</strong>. <strong>Shepherd</strong><br />

PI for Lung<br />

Site<br />

Principal<br />

Investigator<br />

PERIOD<br />

FUNDING<br />

2003-2006 $526,560.00<br />

2004-2007 $848,643.60<br />

AstraZeneca 2004-2006 $190,000<br />

NCI-US 2004-2005<br />

2005-2006<br />

2006-2007<br />

2007-2008<br />

2008-2009<br />

Jacqueline<br />

Seroussi<br />

Memorial<br />

Foundation for<br />

Cancer Research<br />

$3,094,228<br />

$3,335,209<br />

$3,674,024<br />

$3,717,333<br />

$3,717,333<br />

2004-2006 $185,000<br />

NCIC-CTG 2003-2006 $36,000<br />

NCI Canada 2004<br />

2005<br />

2006<br />

2007<br />

2008<br />

$3,717,333<br />

$5,117,333<br />

$5,117,333<br />

$5,117,333<br />

$5,117,333<br />

NCIC CTG 2001-2004 $132,000 total<br />

Co-investigator Pfizer 2004-2006 $30,000<br />

3

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