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Dr. Frances Shepherd CV - (NCRI) is

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Molecular prognostic markers in early<br />

stage NSCLC<br />

Genomic and proteomic biomarkers<br />

of response to EGFR inhibitors in<br />

NSCLC<br />

Gene expression profiling and<br />

molecular classification of lung<br />

cancer<br />

Phase III trial of induction<br />

chemotherapy vs surgery alone for<br />

Stage III NSCLC<br />

Phase III trial of gemcitabine/c<strong>is</strong>platin<br />

+/-LY-293111 in NSCLC<br />

Phase II trial of ZD6474 vs placebo in<br />

responding patients with SCLC<br />

Novel molecular prognostic markers<br />

and potential therapeutic targets in<br />

non-small cell lung cancer<br />

Phase II trial of gemcitabine/c<strong>is</strong>platin<br />

+/- cetuximab in patients with<br />

advanced NSCLC<br />

Phase III trial of placebo versus Iressa<br />

in advanced NSCLC<br />

Phase I trial of paclitaxel and<br />

carboplatin and AZD2171 in<br />

advanced NSCLC NCIC IND.171<br />

Phase I trial of gemcitabine and<br />

c<strong>is</strong>platin increasing doses of<br />

AZD2171 in advanced NSCLC NCIC<br />

IND.175<br />

Genomic profiles of lung cancer that<br />

predict prognos<strong>is</strong> and response to<br />

adjuvant chemotherapy.<br />

Phase I trial of paclitaxel and<br />

carboplatin +/- AZD2171 in advanced<br />

NSCLC NCIC BR.24<br />

Molecular predictors of outcome in<br />

BR.19 a phase III trial of adjuvant<br />

gefitinib post resection of early stage<br />

non-small cell lung cancer<br />

Randomized Phase II trial of RAD001<br />

in advanced NSCLC<br />

Co-investigator<br />

<strong>Dr</strong>. M Tsao PI<br />

Co-investigator<br />

<strong>Dr</strong>. M Tsao PI<br />

Co-investigator<br />

<strong>Dr</strong>. MS Tsao PI<br />

OCRN<br />

(02-MAY-0132)<br />

OCRN<br />

(02-APR-0324)<br />

Co-Investigator NCI US and<br />

CTEP<br />

2003-2006 $429,600.00<br />

2003-2006<br />

$526,000.00<br />

NCIC 2004-2009 $750,000.00<br />

2002-2004 $18,00.00<br />

Co-investigator Eli Lilly 2003-2004 Per case<br />

funding<br />

$48,000 total<br />

Co-Investigator<br />

Institutional PI<br />

Co-applicant<br />

<strong>Dr</strong>. MS Tsao PI<br />

NCIC CTG 2004-2006 $30,000.00<br />

NCIC<br />

Grant #015184<br />

International PI Br<strong>is</strong>tol Myers<br />

Squibb<br />

Co-Investigator<br />

Institutional PI<br />

2004-2009 $150,000/ year<br />

x 5 yrs<br />

2005 Per patient<br />

funding<br />

$36,000.00<br />

Novart<strong>is</strong> 2005-2006 Per patient<br />

funding<br />

$24,000.00<br />

Co-investigator NCIC CTG 2005-2006 Per patient<br />

funding<br />

$12,000.00<br />

Co-investigator NCIC CTG 2005-2006 Per patient<br />

funding<br />

$24,000.00<br />

Co-Investigator<br />

<strong>Dr</strong>.M-S Tsao PI<br />

Local Principal<br />

Investigator<br />

Co-Investigator<br />

<strong>Dr</strong>. I. Lorimer PI<br />

Local Principal<br />

Investigator<br />

OCRN<br />

04-May-00133<br />

2005 -2008 $489,900<br />

NCIC CTG 2006-2008 Per patient<br />

funding<br />

$240,000.00<br />

OCRN<br />

05NOV 00186<br />

2006-2009 $476, 640<br />

Novart<strong>is</strong> 2005-2006 $130,000.00<br />

Randomized Phase II trial of Local Principal Millenium 2005-2007 Per patient<br />

4

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