Mixing and Granulation - GEA Pharma Systems
Mixing and Granulation - GEA Pharma Systems
Mixing and Granulation - GEA Pharma Systems
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In processs measurement position Clean <strong>and</strong> calibrate position CIP position at end of processEnd-point controlA choice of automated end-point control facilities,with trending for process optimization, is offeredwith all of the system control options - manual aswell as PLC-based. Options include fixed processtime, automatic end-point control based on powerconsumption, <strong>and</strong> a high-accuracy torque-basedsystem. Both the power- <strong>and</strong> torque-based optionscan be used to optimize spray rate <strong>and</strong> wet massingtime, for faster, more uniform granule growth.It is also possible to control in-line the growth of thegranules with FBRM.Power (kW)35Installed power 45kW302533 litres2038 litres15105End pointEnd point00 2 4 6 8 10 12 14 16 18 20 22 24Time (minutes)M8 BladeSt<strong>and</strong>ard Blade<strong>Granulation</strong> comparisonInsoluble active<strong>Granulation</strong> graph showing the improvementsgained in a straight walled vessel when using the M8impeller, include reduction in binder solution,reduced granulation time <strong>and</strong> enhanced end-pointdefinition.Lighthouse ProbeTechnology<strong>GEA</strong> <strong>Pharma</strong> <strong>Systems</strong> (GPS) has joinedforces with J&M GmbH to create acompact <strong>and</strong> cleanable in-process opticalprobe for use in powder processingequipment.The result is the novel Lighthouse Probe, whichcan be used with a range of spectroscopictechniques, including NIR <strong>and</strong> UV/vis, to overcomethe traditional problem of product sticking toobservation windows.The probe is compact <strong>and</strong> easy to install <strong>and</strong> makesit possible to take a reliable in process measurementof quality critical product characteristics including:• Material <strong>and</strong> active content identification• Active content uniformity during highshear blending operations• Moisture content <strong>and</strong> end-point duringdrying processes• Coat growth during coating processesOptical methods such as UV/Vis or NIRspectroscopy can be very powerful tools foranalysing a range of product characteristics, but inprocesses involving wet <strong>and</strong> sticky powders it isnecessary to ensure that the system has a clear viewof the product. Conventional windows used inprocess equipment such as fluid bed systems or highshear granulators, have always suffered from therisk of window fouling. The new GPS & J&MLighthouse Probe has overcome this problem.9
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