Laparoscopic repair in perforated peptic ulcer

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Laparoscopic repair in perforated peptic ulcerIn open procedure after thorough peritoneallavage, perforation is closed with or with outreinforcement of omental patch. Few surgeonsduring emergency peptic ulcer surgery haveadequate experience with selective vagotomy,therefore it is recommended that suture oromental flap is followed by medical treatmentincluding elimination of H pylori if present otherwisemaintain on proton pump inhibitor. 13Laparoscopic treatment of PPU was first reportedby Mouret et al in 1989 14 followed soon afterby Nathanson et al. 15 The recognized advantagesof laparoscopy are decreased postoperative pain,early mobilization, early return to work andlower complication rate, make this treatmentmodality attractive to many surgeons all over theworld. Nonetheless there are relative contra indicationswhich include elderly patients, cardiacpathology, chronic respiratory insufficiency,obesity, cirrhosis and sever coagulopthies.There are variety of techniques to close the perforationlaparoscopically such as intra and extracorporeal knots, holding omental path with fibringlue or sealing with gelatin etc. The aim ofthis study was to evaluate the efficacy and safetyof laparoscopic closure of PPU and also identifythose patients who are not suitable for this treatmentmodality.Materials and Methods:Total 25 patients were recruited for this prospectivestudy. This study was conducted from July2007 to June 2010 and all patients were attemptedfor laparoscopic closure of PPU in SurgicalUnit 3, PMCH and private hospital. The diagnosiswas based on sudden onset of severe, sharpabdominal pain present in epigastrium or generalizedpain accompanied by nausea and vomiting.On examination obvious distress, tachycardia,tachypnoea along with abdominal signs oftenderness guarding and rigidity. Patients werealso asked about past history of PUD, intake ofNSAIDS, alcohol and smoking. Routine investigationssuch as Blood CP, serum amylase, bloodurea, chest x-ray in erect posture and US werealso performed to reach the diagnosis. Exclusioncriteria for this procedure were extensiveperitonitis, upper abdominal incision, patients174presented 24 hours after perforation and shock.Parameters observed were operative time, intraoperative and post operative complication, painmanagement, hospital stay and rate of conversionto open surgery. Once the diagnosis of PPUwas established patient resuscitated aggressivelybefore the operation. Laparoscopy performedvia 4 ports one port in the umbilicus for camera,2 working ports at right and left upper abdomenand one port in the epigastrium to retract thequadrate lobe of the liver. 2-0 vicryl used for closureof perforation and omental patch anchoredover the perforation with vicryl stitche to sealthe perforation completely, thorough abdominallavage performed with saline.Results:In 25 consecutive patient’s laparoscopic closureof perforated peptic ulcer (PPU) attempted.There were 20 (80%) patients males and 5(20%)females (Figure-1). The mean age was 42.2(22-75) years (Figure-2). The mean operativetime was 75 (55 to 110) minutes. Patients havestarted oral intake from third day. The mean postoperative hospital stay was 5-8 days. In 5(16%)24%20%20%16%24%80%Figure 1: Sex Distribution (n= 25)16%Figure 2: Age Distribution (n= 25)FemaleMale65-7555-6545-5535-4525-35Pak J Surg 2011; 27(3): 173-176
175 AR Qazi , AA Leghari, PS Shahpatients conversion to open procedure was necessitateddue to following reasons, i.e large sizeof ulcer, suspected malignancy in gastric ulcerand presence of local abscess (Table-1). Thepostoperative complications were chest infectionrecurrence of perforation, infection of umbilicalport and subphrenic abscess (Table-2).Discussion:Advances in medical treatment of PUD havedramatically reduced the number of electiveProcedure performed for this disease. Nonethelessthe rate of complications appears to beunchanged. PPU is a notorious complicationof PUD frequently leads to peritonitis. Initialtreatment to be directed toward correction ofhypovolaemia and any electrolyte imbalance.Oliguria and poor peripheral perfusion are contraindicationto immediate operative treatmentand their correction should take precedenceeven over radiological studies. 16 There is nodoubt that some patients with perforated ulcercan be managed non operatively with successfulout come. The problem with this approach,which is reserved for poor risk elderly patients,is a high incidence of a residual abscess formation,particularly in subphrenic region whichwill subsequently require drainage. 17 The issuethat has been raised often is whether the patientwith perforated peptic ulcer must be operatedon by an open procedure or laparoscopic techniqueshould be employed. Simple closure withomental patch is not a demanding procedure fora surgeon who is able to perform intracorporealknots. The choice between combining definitivetreatment and simple closure of the perforationis still a matter of controversy. This choice dependupon certain factors, including the age andfitness of the patient and the status of peritonealcavity. 18 Laparoscopy has significant advantagethat it allows more accurate visualization of peritonealcavity and can evacuate collection of fluidTable 1: Reasons for Conversion (n=25)Number ofReasonsPatients(%)Large size of Perforation (>1cm) 02(33%)Local Abscess 02(33%)Gastric Cancer 01(16%)which may be distant from perforation. Otherestablish advantages are less postoperative painwhich is supported by significant reduction inpost operative analgesic requirement, avoidanceof excessive gut manipulation reflects inshort period of ileus, early oral intake of food.Early mobilization , short hospital stay an earlyresumption of work make this technique an attractivealternative to laparotomy. However thisapproach is not as popular as laparoscopic cholecystectomydue to disadvantages of significantlyprolong duration of operation and high rate ofsuture leak requiring repeated operation. Duringthe 2 years study period we only manage to select25 patients due to strict criteria in which weexcluded patients with any risk factors, patientspresented 24 hours after perforation and due tolack of facility of laparoscopy in emergency onlyfew patients underwent procedure at electivelist, however majority of patients were operatedat private hospital. In our study duration ofoperation was average 75 (65 to 110) minutes,which is consistent with studies conducted bySchirus e al 19 and different from Mastuda 20 . Oneof disadvantages of this technique is significantlylonger time than open procedure, howeverwith increasing expertise the operative time oflaparoscopy become shorter. In our series parenteralanalgesics were given for first 2 days. Averagehospital stay was 6.5 (5 to 8) days, whichwas also observed by Arnaude al 21 . 4( 5.7 %) patientsnecessitated conversion to open ,the mostcommon reasons were large size(more than 1cm), gastric cancer and presence of abscess. Thepostoperative complications were chest infections,subphrenic abscess and re-operation dueto suture leak. Abscess was drained under ultrasoundand leak required repeated procedure. Siuet al 22 found that laparoscopic repair PPU wasa safe and reliable procedure, associated with ashorter operating time, less postoperative pain,Table 2: Post Operative Complication (n=25)Number ofComplicationPatients(%)Recurrent Perforation 02(08%)Chest Infection 02(08%)Port Infection 01(04%)Subphrenic Abscess 01(04%)Pak J Surg 2011; 27(3): 173-176
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Laparoscopic repair in perforated peptic ulcer

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