Hurp and acentriolar spindle assembly in the mouse oocyte ... - eshre
Hurp and acentriolar spindle assembly in the mouse oocyte ... - eshre
Hurp and acentriolar spindle assembly in the mouse oocyte ... - eshre
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<strong>Hurp</strong> <strong>and</strong><strong>acentriolar</strong> <strong>sp<strong>in</strong>dle</strong> <strong>assembly</strong> <strong>in</strong> <strong>the</strong> <strong>mouse</strong> <strong>oocyte</strong>Stéphane BrunetManuelBreuerMarie-Hélène Verlhac groupDevelopmental Biology CNRS-U Paris 6, France
Mito-ccentriolar<strong>sp<strong>in</strong>dle</strong><strong>assembly</strong>http://mitchison.med.harvard.edu/NEBDMTs DNA
Chromosomes,Ran‐GTP<strong>and</strong>Sp<strong>in</strong>dleAssemblyFactorsac
MeiosisI<strong>acentriolar</strong><strong>sp<strong>in</strong>dle</strong><strong>assembly</strong>MTs DNA GVBD +2h +4h +8h‐ Howisbipolarityset‐up<strong>in</strong><strong>the</strong>absenceofcentrioles?‐ HowdoChromosomespar-cipate<strong>in</strong>thisprocess?
Ran‐GTP<strong>and</strong><strong>acentriolar</strong><strong>sp<strong>in</strong>dle</strong><strong>assembly</strong><strong>in</strong><strong>mouse</strong><strong>oocyte</strong>Ran‐GTP+ +t postGVBDDumontetal,JCB2007Ran‐GTPtarget(s)<strong>in</strong>volved<strong>in</strong><strong>sp<strong>in</strong>dle</strong>bipolariza
TPX2isaRanGTPdependantmicrotubulenucleatorTPX2ac-veMicrotubule<strong>assembly</strong>RanGDPTPX2<strong>in</strong>ac-ve
TPX2deple
TPX2accumulatesprogressivelydur<strong>in</strong>gmeio
Jessica AzouriManuel BreuerStephane BrunetJean Philippe ChambonPascale HikalAgneswska KolanoKaren Lee W<strong>in</strong>gmanMarie-Hélène VerlhacT<strong>in</strong>g‐FenTsai,Taiwan
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