- Page 1 and 2: Sample Size and PowerLaura Lee John
- Page 3 and 4: Take Away Message• Get some input
- Page 5 and 6: Superiority vs. EquivalenceSuperior
- Page 7 and 8: Vocabulary (2)• Follow-up period-
- Page 9 and 10: Power Depends on Sample Size• Pow
- Page 11 and 12: Power Changes• 2n = 32, 2 sample
- Page 13: Power should be….?• Phase III:
- Page 17 and 18: Sample Size Formula Information•
- Page 19 and 20: Sample Size & Study Design• Rando
- Page 21 and 22: Take Away• Study’s primary outc
- Page 23 and 24: Sample Size in Clinical Trials• T
- Page 25 and 26: Phase I (Old Way)• Enroll 3 patie
- Page 27 and 28: Phase IEnroll 3 people0/3 DLT 1/3 D
- Page 29 and 30: Phase IEnroll 3 people0/3 DLT 1/3 D
- Page 31 and 32: Phase IEnroll 3 people0/3 DLT 1/3 D
- Page 33 and 34: Phase I (cont.)• Maximum Tolerate
- Page 35 and 36: Phase I Note• *Implicitly targets
- Page 37 and 38: Phase II Designs• Screening of ne
- Page 39 and 40: Phase II Example:Two-Stage Optimal
- Page 41 and 42: Two-Stage Optimal Design• Let α
- Page 43 and 44: Blow up: Simon (1989) Table
- Page 45 and 46: Phase II Example• If 4-10 of the
- Page 47 and 48: Phase II• Newer methods are avail
- Page 49 and 50: Phase II: Historical Controls• Ol
- Page 51 and 52: Phase III Survival Example• Prima
- Page 54 and 55: 341213
- Page 57 and 58: Non-Survival Simple Sample Size•
- Page 59 and 60: Sleep Aid Example• 1 sample test
- Page 61 and 62: Sample Size:Change Effect or Differ
- Page 63 and 64: Sample Size: Change Power• Change
- Page 65 and 66:
Sleep Aid Example: 2 ArmsInvestigat
- Page 67 and 68:
Aside: 5 Arm Study• Sample size p
- Page 69 and 70:
Sample Size: Change Power• Change
- Page 71 and 72:
Conclusion• Changes in the differ
- Page 73 and 74:
Example• Calculate power with the
- Page 75 and 76:
JAVA Sample Size
- Page 77 and 78:
Move the Values Around• Sigma (st
- Page 79 and 80:
Keep Clicking “OK” Buttons
- Page 81 and 82:
Sample Size:Matched Pair Designs•
- Page 83 and 84:
Cohen's Effect Sizes• Large (.8),
- Page 85 and 86:
Take Home: N• Difference (effect)
- Page 87 and 88:
Unequal #s in Each Group• Ratio o
- Page 89 and 90:
Unequal #s in Each Group:Fixed # of
- Page 91 and 92:
# of Events is Important• Cohort
- Page 93 and 94:
# of Covariates and # of Subjects
- Page 95 and 96:
OutlinePowerBasic Sample Size Infor
- Page 97 and 98:
DNA Microarrays/Proteomics• Same
- Page 99 and 100:
Me, too! No, Please Justify N• "A
- Page 101 and 102:
Variance?• No prior information o
- Page 103 and 104:
OutlinePowerBasic Sample Size Infor
- Page 105 and 106:
No Estimate of the Variance?• Mak
- Page 107 and 108:
Top 10 Statistics Questions7. Each
- Page 109 and 110:
Top 10 Statistics Questions1. Repea
- Page 111 and 112:
Resources: General Books• Hulley
- Page 113 and 114:
Sample Size Specific Tables• Cont
- Page 115 and 116:
Resources: Articles• Schoenfeld,
- Page 117 and 118:
Resources: URLs• Sample size calc