Gene-Environment Interaction - Zentrales ADHS Netz

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Gene-Environment Interplay• Epigenetic effects of environments on genes• Variations in heritability according to the environment• Gene-environment correlations• Gene-environment interactionsRutter, Moffitt & Caspi (2006) JCPP, 47, 226-261
GxE and ADHD – current findings• DAT1 and prenatal E risks (alcohol, smoking) (Kahn 2003,Brookes 2006, Neuman 2007) and psychosocial adversity (Laucht,2007)• DRD4 and maternal insensitive behavior (Bakermans-Kranenburg 2006) and paternal warmth (Propper 2007)• SERT and adverse environment (Reif 2007) andsocioeconomic status (Nobile 2007)• COMT and low birth weight (Thapar 2005)
Page 1 and 2: Gene-Environment InteractionJan K.
Page 3: Complicating factors in genetic stu
Page 7 and 8: International Study of the Mapping
Page 9 and 10: Prenatal maternal smoking & ADHD -
Page 11 and 12: Parental smoking• Collected by qu
Page 13 and 14: Percentage maternal and paternal sm
Page 15 and 16: Smoking, ADHD / non-ADHD, and atten
Page 17 and 18: Results• Paternal smoking is sign
Page 19 and 20: Maternal smoking & IQ (Frazier et a
Page 21 and 22: Genes related to ADHD may affect IQ
Page 23 and 24: MethodsUnited KingdomIrelandNetherl
Page 25 and 26: Statistical AnalysesLinear Mixed Mo
Page 27 and 28: Effect maternal smoking on IQ, sepa

Gene-Environment Interaction - Zentrales ADHS Netz

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