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LITHIUM AUGMENTATIONSTUDIES IN OLD AGEn Antidepressant % responseLafferman et al 1988 14 Mixed 71Finch & Katona 1989 9 Lofepramine 66van Marwijk et al 1990 51 Cyclic 65Zimmer et al 1991 15 Nortriptyline 66Flint and Rifat 1994 20 Nortriptyline 35Uehlinger et al 1995 5 Citalopram 80
METHYLPHENIDATE16 medically ill patientsMean age 72.3Placebo crossover (2 x 4 days)Active regime 5mg bd for 2 days, then 10mg bd13 completedMethylphenidate superior to placebo7 responders3 partial respondersNegligible side effectsWallace et al 1995
Page 1 and 2: Depression in Old AgeCornelius Kato
Page 3 and 4: Overview• Epidemiology• Details
Page 5 and 6: StudyDiagnosticcriterianAge% ‘Maj
Page 7 and 8: Prevalence of affectivedisorders ac
Page 9 and 10: Morbidityn %Anxiety disorderDementi
Page 11 and 12: Psychotropic drug usageTotalpopulat
Page 13 and 14: Why is depression not treatedin old
Page 15 and 16: The Geriatric Depression Scale (GDS
Page 17 and 18: GDS-4Are you basically satisfied wi
Page 19 and 20: Treatment options• Need for holis
Page 21 and 22: Newer antidepressants• SSRIs- flu
Page 23 and 24: NUMBER NEEDED TO TREAT• Number of
Page 25 and 26: Authors Drug N Measure NNT 95% CIac
Page 27 and 28: Authors Drugs N (Drug1)Nair et al95
Page 29 and 30: MeanHAM-Dtotal scoreElderly depress
Page 31 and 32: • Effective• Safe- Mulsant et a
Page 33 and 34: Depression and interpersonaltherapy
Page 35 and 36: Citalopram vs placebo in comorbidde
Page 37 and 38: 01234Response of neuropsychiatric a
Page 39 and 40: Risk of depression inphysically ill
Page 41 and 42: Mortality following hip fracture%Ps
Page 43 and 44: Lofepramine vs Placebo4 week trialL
Page 45 and 46: Fluoxetine vs Placebon=8262 complet
Page 47: Lithium• Effective in prophylaxis
Page 51 and 52: ECT vs Paroxetine• RCT• n=39•
Page 53 and 54: Prognostic community studies ofdepr
Page 55 and 56: Cattell and Jolley, 1995• 100 con
Page 57 and 58: Logistic regressionp
Page 59 and 60: Prevention of depressionrecurrence
Page 61 and 62: Antidepressant +PsychotherapyNT+ NT

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