improves care. Dr Shennan focuses on the assessment of risk, close antenatalsurveillance and timely delivery. Dr Uzan continues to champion the use ofaspirin for prevention of preeclampsia, even though the evidence is contradictory.Dr Sibai addresses the lack of evidence for calcium, vitamin C and E inprevention of preeclampsia. Dr Von Dadelszen is developing a new paradigm forthe classification of these disorders and emphasizes the importance of evidencebasedintervention. SUMMARY: Evidence suggests that treatment of severehypertension, seizure prophylaxis with magnesium sulfate, and management byexperienced healthcare professionals will improve maternal, fetal and neonataloutcomes. Well designed studies will lead to evidence-based improvement incaring for mothers and babies worldwide.Curr Opin Obstet Gynecol. <strong>2008</strong> Apr;20(2):91-95.Hypertensive emergencies in pregnancies in underresourced countries.Moodley J.Womens Health and HIV Research Group, Department of Obstetrics andGynaecology, Nelson R Mandela School of Medicine, University of KwaZulu-Natal, Congella, South Africa.Gynecol Obstet Invest. <strong>2008</strong>;65(2):81-3. Epub 2007 Sep 13.Placenta percreta leading to spontaneous complete uterine rupture in thesecond trimester. Example of a fatal complication of abnormal placentationfollowing uterine scarring.Fleisch MC, Lux J, Schoppe M, Grieshaber K, Hampl M.Department of Obstetrics and Gynaecology, Heinrich Heine University,Dusseldorf, Germany. Fleisch@uni-duesseldorf.deA 30-year-old gravida 2 para 1 was admitted to hospital 2 years after cesareansection at 20 weeks' gestation with acute onset of abdominal pain andhypovolaemic shock. Emergency laparotomy revealed a uterine rupture locatedin the anterior uterine wall caused by a placenta percreta and supracervicalhysterectomy was performed. This site of invasion and finally rupture was inprojection of the previous lower-segment cesarean section. This report illustratesthe dramatic consequences of abnormal placentation after prior uterine surgery,which can already occur early during pregnancy and prior to the onset of labour.(c) <strong>2008</strong> S. Karger AG, Basel.J Perinatol. <strong>2008</strong> Apr;28(4):310-2.Normoglycemic diabetic ketoacidosis in pregnancy.Chico M, Levine SN, Lewis DF.1Section of Endocrinology and Metabolism, Department of Internal Medicine,Louisiana State University Health Sciences Center, Shreveport, LA, USA.The clinical presentation of diabetic ketoacidosis in pregnancy is usually thesame as in nonpregnant women, although the blood glucose may not be as highas in the nongravid state. We report a case of a pregnant woman who developeddiabetic ketoacidosis with a normal blood glucose and review the pertinentmedical literature. A 29-year-old woman with type I diabetes developed diabetic
ketoacidosis during induction of labor. She had a glucose level of 87 mg per 100ml with ketonuria, a metabolic acidosis, and an anion gap of 20 mmol l(-1).Normoglycemic diabetic ketoacidosis during pregnancy is truly unusual but canoccur with relatively low, or even normal, blood sugars and necessitates promptrecognition and treatment. In this case, the combination of an initial episode ofhypoglycemia and subsequent blood glucose levels below 95 mg per 100 ml ledto a prolonged delay in the initiation of a planned insulin infusion for insulincoverage during the induction of labor. A significant ketoacidosis consequentlydeveloped, despite the absence of even a single elevated blood glucosemeasurement. This case illustrated the importance of not withholding insulin in apatient with type I diabetes for more than a few hours even if the blood glucoseis normal.Journal of Perinatology (<strong>2008</strong>) 28, 310-312; doi:10.1038/sj.jp.7211921.Obstet Gynecol. <strong>2008</strong> Apr;111(4):1001-20.ACOG Practice Bulletin No. 92: Use of Psychiatric Medications DuringPregnancy and Lactation.[No authors listed]Obstet Gynecol. <strong>2008</strong> Apr;111(4):927-934.Pregnancy Outcomes in Systemic Sclerosis, Primary PulmonaryHypertension, and Sickle Cell Disease.Chakravarty EF, Khanna D, Chung L.Division of Immunology and Rheumatology, Department of Medicine, StanfordUniversity School of Medicine, Palo Alto, California; Division of Rheumatology,Department of Medicine, David Geffen School of Medicine at University ofCalifornia Los Angeles, Los Angeles, California; and Palo Alto Veterans AffaireHealth Care System, Palo Alto, California.OBJECTIVE: Systemic sclerosis, primary pulmonary hypertension, and sickle celldisease are uncommon vasculopathic diseases affecting women. We estimatedthe nationwide occurrence of pregnancies in women with these conditions andcompared pregnancy outcomes to the general obstetric population. METHODS:We studied the2002-2004 Nationwide Inpatient Sample, of the Healthcare Costand Utilization Project to estimate the number of obstetric hospitalizations anddeliveries amongwomen with systemic sclerosis, primary pulmonaryhypertension, sickle cell disease, and women in the general population.Pregnancy outcomes included length of hospital stay, hypertensive disordersincluding preeclampsia, intrauterine growth restriction (IUGR), and cesareandelivery. Multivariable regression analyses were performed using maternal age,race or ethnicity, antiphospholipid antibody syndrome, diabetes mellitus, andrenal failure as covariates. RESULTS: Of an estimated 11.2 million deliveries,504 occurred in women with systemic sclerosis, 182 with primary pulmonaryhypertension, and 4,352 with sickle cell disease. Systemic sclerosis, wasassociated with an increased risk of hypertensive disorders includingpreeclampsia (odds ratio [OR] 3.71, 95% confidence interval [CI] 2.25-6.15),IUGR (OR 3.74, 95% CI 1.51-9.28), and increased length of hospital stay.Primary pulmonary hypertension was associated with an increase in the odds of
- Page 1 and 2: Obstetricia CríticaEduardo Malvino
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- Page 17 and 18: of one per 1500 pregnant women. Cal
- Page 19 and 20: Background: To investigate the rela
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- Page 25 and 26: years old (n = 23,921). Univariate
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- Page 43: Callaway LK, Lawlor DA, McIntyre HD
- Page 47 and 48: and low platelets (HELLP) syndrome.
- Page 49 and 50: Division of Reproduction and Endocr
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- Page 53 and 54: significantly associated with psori
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- Page 63 and 64: mEq/l) metabolic acidosis. Other et
- Page 65 and 66: Acta Obstet Gynecol Scand. 2008;87(
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Department of Obstetrics and Centre
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developed any new problems. CONCLUS
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It seems to be safe to continue bre
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colonization in a subsequent pregna
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Crude and adjusted odds ratios were
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the subsequent development of ESRD.
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Acta Obstet Gynecol Scand. 2008 Sep
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OBJECTIVE: To investigate pregnancy
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OBJECTIVE: To compare the perinatal
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exceptionally rare. CASE: A 23-year
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CONCLUSION: This case demonstrates
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peripartum hysterectomy included ce
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BMJ. 2008 Sep 8;337:a1397. doi: 10.
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Lancet. 2008 Sep 17. [Epub ahead of
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Obstet Gynecol. 2008 Oct;112(4):951
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Additionally, the effects of distur
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analyzed. Initial echocardiographic
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pathologic or anatomically anomalou
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Eur J Obstet Gynecol Reprod Biol. 2
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chorioamnionitis; and (3) in contra
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underlying conditions related to st
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third trimester of pregnancy.BMJ. 2
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Texas Health Science Center, Housto
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preterm birth before 34 weeks (P
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cases. Most patients (91%) received
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Ultrasound Obstet Gynecol. 2008 Nov
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Maggard MA, Yermilov I, Li Z, Magli
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Clinical and Population Health, Per
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the biologic mechanism is unclear,