Abstracts – 2008 - Obstetricia Crítica

Department of Obstetrics and Gynecology, Washington University in St Louis, StLouis, MO, USA.OBJECTIVE: The purpose of this study was to examine the rate of and risks forabruption and adverse pregnancy outcome after minor trauma in pregnancy.STUDY DESIGN: This is a 3-year prospective cohort study of patients afternoncatastrophic trauma. Data collected included maternal demographics andhistory, trauma mechanism, and pregnancy outcome. Examination, lab testsincluding Kleihauer-Betke (KB), and a minimum of 4 hours of fetal monitoringwere performed. The primary outcomes were placental abruption and acomposite pregnancy morbidity outcome. Univariate and bivariate analysis wereperformed. RESULTS: Of the 317 patients evaluated for minor trauma, 9 had apositive KB test (2.8%). Delivery information was available on 256 (81%)patients, and there was 1 placental abruption. The 49 cases (19.4%) ofcomposite outcome could not be predicted. CONCLUSION: Perhaps it is time toreevaluate the extensive evaluations often done after minor trauma in pregnancy,particularly because none of the commonly used objective measures arepredictive of adverse outcomes.Am J Obstet Gynecol. 2008 Feb;198(2):178.e1-7.Acetaminophen use during pregnancy: effects on risk for congenitalabnormalities.Rebordosa C, Kogevinas M, Horváth-Puhó E, Nørgård B, Morales M, CzeizelAE, Vilstrup H, Sørensen HT, Olsen J.Autonomous University of Barcelona, Barcelona, Spain. crebordosa@imim.esOBJECTIVE: We evaluated if acetaminophen, one of the most frequently useddrugs among pregnant women is associated with an increased prevalence ofcongenital abnormalities. STUDY DESIGN: We selected 88,142 pregnant womenand their liveborn singletons from the Danish National Birth Cohort who hadinformation on acetaminophen use during the first trimester of pregnancy. Weused the National Hospital Registry to identify 3784 (4.3%) children from thecohort diagnosed with 5847 congenital abnormalities. RESULTS: Childrenexposed to acetaminophen during the first trimester of pregnancy (n = 26,424)did not have an increased prevalence of congenital abnormalities (hazard ratio =1.01, 0.93-1.08) compared with nonexposed children (n = 61,718). Noassociation was found between congenital abnormalities and duration of useduring the first trimester. Increased prevalence was not observed for specificabnormalities, except for "medial cysts, fistula, sinus" (congenital abnormalities ofthe ear, face, and neck, ICD-10 code Q18.8, n = 43) with an adjusted hazardratio of 2.15 (1.17-3.95). CONCLUSION: Acetaminophen is not associated withan increased prevalence of congenital abnormalities overall or with any specificgroup of major abnormalities.Am J Obstet Gynecol. 2008 Jan 24 [Epub ahead of print]Hyperemesis gravidarum that requires hospitalization and the use ofantiemetic drugs in relation to maternal body composition.Cedergren M, Brynhildsen J, Josefsson A, Sydsjö A, Sydsjö G.