Wound Healing & Limb Salvage - New Jersey Center for Biomaterials

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How can we grow skin ?1. Molecular tools allow <strong>for</strong> purification and isolation ofEpidermal Stem Cells from which one can recreate fullydifferentiated epidermisIRSBulgeORSDermalpapillaStem Cell+ Niche TransitAmplifyingCellsDifferentiatingCellsEpidermisMorasso MI and Tomic-Canic, M. Biol Cell. 200597(3):173-83.
Opportunities3. Epidermal stem cells (ESC) can be geneticallyengineered to sustain persistent expression of a transgenein tissue engineered skinCultured ESC transduced with b-galgene sustain its expression inxenograft <strong>for</strong> more than a yearGhazizadeh S and Taichman LB : EMBO J (2001) 20, 1215–1222;1222;J Invest Dermatol. (2005) 124(2):367-72
Page 1: Wound Healing & LimbSalvageDr. Haro
Page 4 and 5: …16,653 Americans wounded in Iraq
Page 6 and 7: 441 limbs lost (337 lower extremity
Page 8 and 9: Healing traumatic wounds : Could th
Page 10 and 11: YES!Ulcer healed at 7 weeks.Brem H,
Page 12 and 13: What is Cell Therapy?cell therapy i
Page 14 and 15: Use of Tissue Engineered Skin Alrea
Page 16 and 17: Figure 1ACan toe ulcers be a source
Page 18 and 19: Mechanism of Cell Therapy:Keratinoc
Page 20: Is Amputation Necessary?TendonTendo
Page 23 and 24: Can Telemedicine Accelerate WoundCl
Page 25 and 26: How do you interpret data? Percenta
Page 27 and 28: How much does a non healing woundco
Page 29 and 30: Demographics:145 Consecutive Hospit
Page 31 and 32: What are theexpected healing rates?
Page 33 and 34: Adenovirus Delivery System
Page 35: Human cell bankThrough partnership
Page 39 and 40: Human Skin Equivalent (HSE) Reconst
Page 41 and 42: c-myc IS INDUCED IN NON HEALING WOU
Page 43 and 44: Location ABench to Bedside: From Mi
Page 45 and 46: Amphibian LimbRegenerationWound Hea
Page 47: Human LimbRegeneration1. Healing Ve

Wound Healing & Limb Salvage - New Jersey Center for Biomaterials

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