Copyright by Radhika Anantharaman Nair 2005 - The University of ...

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2000, 454 accounted for only 1.2 percent (0.3 million) of prescriptions written foradvertised drugs.Demographic Characteristics (Age, Gender) and Health Insurance CoverageThis section presents the demographic characteristics of the individuals withgastrointestinal-related physician visits and individuals who received prescriptions foradvertised gastrointestinal drugs. Among individuals who reported gastrointestinalcomplaints and/or were diagnosed with a gastrointestinal problem, the percentage ofwomen, percentage of individuals with health insurance coverage, and percentage ofindividuals 45 years and older were identified (Figure 5.25).Figure 5.25: Trends in Percentage of Women, Percentage of Individuals with HealthInsurance Coverage, and Percentage of Individuals 45 years and Older Amongthose with Gastrointestinal-Related Visits, 1994-2001Percent1008060402091.4 90.3 90.964.0 61.963.954.5 52.495.0 94.4 95.2 94.7 93.663.162.357.960.8 60.5 57.9 60.362.561.657.2 56.801994 1995 1996 1997 1998 1999 2000 2001YearPercent Individuals with Health Insurance CoveragePercent WomenPercentage of Individuals 45 years and olderNote – Percent was calculated from total number of individuals with gastrointestinal-related visitsAmong individuals who reported gastrointestinal-related symptoms and/or werediagnosed with gastrointestinal-related conditions, the majority were women (56.8-454 Glaxo Wellcome Decides to Withdraw Lotronex from the Market. Food and Drug Administration.November 28, 2000. Available at: http://www.fda.gov/bbs/topics/ANSWERS/ANS01058.html.Accessed September, 2004.264
64.0%), had health insurance coverage (90.3-95.2%) and were 45 years and older (52.4-62.5%).Figure 5.26 describes the trends in the percentage of women, percentage ofindividuals with health insurance coverage and percentage of individuals 45 years andolder among those received a prescription for an advertised gastrointestinal drug. Amongthose who received a prescription, women accounted for 56.1-62.0 percent whereas thosewith coverage ranged from 91.7-96.8 percent from 1994 through 2001.Figure 5.26: Trends in Percentage of Women, Percentage of Individuals with HealthInsurance Coverage, and Percentage of Individuals 45 years and Older Amongthose who Received Prescriptions for Advertised Gastrointestinal Drugs*, 1994-2001Percent100.080.060.040.095.494.2 91.7 93.7 94.3 96.4 96.6 96.870.078.775.8 76.8 80.3 77.8 82.577.456.8 59.4 60.856.1 61.6 58.2 59.6 62.020.00.01994 1995 1996 1997 1998 1999 2000 2001YearPercent Individuals with Health Insurance CoveragePercent WomenPercent Individuals 45 years and older* - Zantac®, Propulsid®, Prilosec®, Prevacid®, Helidac®, Lotronex®Note – Percent was calculated from total number of individuals who received a prescription forgastrointestinals.The majority of the prescriptions written for advertised gastrointestinals were forindividuals 45 years and older (70.0-82.5%). The data for percentage of women,percentage of individuals with coverage and percentage of individuals 45 years and older265
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CopyrightbyRadhika Anantharaman Nai
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EVALUATION OF FACTORS RELATED TO PR
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AcknowledgementsThis dissertation a
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estimate prices of the drugs. Time
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PageRegulatory Changes in 1997 and
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PageCHAPTER 4: METHODOLOGY . . . .
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PagePrescription Drug Expenditures
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PageObjective II . . . . . . . . .
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PageDTCA Expenditures . . . . . . .
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LIST OF TABLES PageTable 2.1: Regul
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PageTable 5.20: Mixed Model Analyse
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PageTable 6.5: Results for Hypothes
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PageFigure 5.4: Trends in Total DTC
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PageFigure 5.30: Trends in Total DT
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CHAPTER 1: INTRODUCTIONBACKGROUNDPr
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Figure 1.2: Annual Percent Change i
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addition, the guidelines for detect
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Direct-to-Consumer Advertising Expe
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of the guidelines, manufacturers fe
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percent whereas private health insu
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public coverage has remained about
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According to the National Center fo
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As mentioned previously, DTCA can a
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one drug prescribed has not increas
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drugs is encouraged. 66 All these f
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(a) To determine the relationships
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enefit of DTCA, many claim that DTC
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persistent and will shop around unt
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advertisements describe and discuss
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These advertisements were aired mai
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During this time, the FDA realized
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included media tours in which physi
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care for their condition, it does n
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It is possible that due to the infl
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mistakenly believe that there is a
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Thus, advertising could cause patie
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Kefauver-Harris Drug Amendments als
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equire the industry to provide a de
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(d) Provide a statement that inform
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choose which side effects and contr
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The studies that tested these effec
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were more likely to have seen an ad
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disease it treats (51.0%). One-half
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advertised drug and on average used
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about a specific brand (1999-13.0%,
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Table 2.2: Prevention Magazine Surv
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eported that the physician recommen
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Maddox and Katsanis in a study publ
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drug, but not the disease or condit
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and 35.0 percent were prompted to h
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Glasgow et al. identified factors r
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Time, Inc. conducted two surveys of
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not be disappointed in the physicia
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quit smoking were not aware of it.
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2001 study by Allison-Ottey et al.
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and perceived risk. Argument qualit
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esults were obtained from most stud
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In 1997, IMS Health along with Phys
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medication and 7.0 percent gave the
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Results of the studies described in
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The study reported that 46.0 percen
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setting were more likely to have a
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advertising to build brand loyalty
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advertisements, headlines and subhe
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offer to provide more information i
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was increased, recall of risk infor
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SummaryConsumers are increasingly a
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including drugs used to treat high
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the increased prescription drug exp
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Office focus cluster had high expen
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especially detailing. This made it
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to a 47.8 percent increase in presc
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enign prostatic hypertrophy. 311 Ev
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which helped assess the impact of D
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elationship was significant only af
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DTCA expenditures and market share
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classes accounted for 75.0 percent
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DTCA expenditures along with prescr
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eneficiaries with coverage may rece
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utilization of prescription drugs i
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who were uninsured or were enrolled
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Access to Care and Utilization of P
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Among Medicare beneficiaries, suppl
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coverage filled fewer prescriptions
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than men and are receive more presc
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the prescription drug accounted for
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vs. 17.9%) or heavy users (21.4% vs
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visits than men. In 1998, the avera
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each household was causally associa
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eports, employment status, and read
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Demographics (Age and Gender) and U
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drugs use was largely due to drugs
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The study results indicated that th
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though the difference in the averag
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According to the study based on dat
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Summary of the LiteratureThese stud
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In a model predicting prescription
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Summary of the LiteratureUtilizatio
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esults are skewed, especially when
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Several other factors and market dy
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H 1 : An increase in DTCA expenditu
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H 14 : There is no significant rela
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H 24 : An increase in the proportio
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GastrointestinalsObjective ITo dete
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access to care will be significantl
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AntihypertensivesObjective ITo dete
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Data Collection MethodologyThe basi
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As mentioned earlier, CMR also coll
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oadcasting industry survey conducte
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stated previously, data for the rem
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are to be recorded. A perforation b
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truncated, but this leads to an und
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As discussed in Chapter 2, with the
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The total monthly advertising expen
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64 years, 65-74 years, and 75 years
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Table 4.2: United States City Avera
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including chronic conditions (e.g.,
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2000. The ICD-9 CM code for irritab
Page 245 and 246: The ICD-9 CM codes used to identify
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Page 251 and 252: measured for each drug over a perio
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Page 255 and 256: CHAPTER 5: RESULTSChapter 5 will pr
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Page 261 and 262: The number of months represent the
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Page 269 and 270: Figure 5.8: Trend in the Number of
Page 271 and 272: Since 1997, nine out of ten individ
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Page 275 and 276: The total DTCA expenditures for ant
Page 277 and 278: Figure 5.14: Trend in DTCA Expendit
Page 279 and 280: 1994 to $14.3 million in 1995, but
Page 281 and 282: Table 5.6: Number and Percentage of
Page 283 and 284: Figure 5.17: Trends in Percentage o
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Page 287 and 288: Figure 5.20: Trends in Prescription
Page 289 and 290: Since the guidelines for broadcast
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Page 299 and 300: Figure 5.27: Trends in Total Prescr
Page 301 and 302: AntidepressantsDTCA ExpendituresFig
Page 303 and 304: The total DTCA expenditures increas
Page 305 and 306: percentage of visits when the visit
Page 309 and 310: presented in the methodology, the e
Page 311 and 312: Figure 5.35: Trends in Prescription
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Page 315 and 316: antihypertensives and number of hyp
Page 317 and 318: Figure 5.38: Trend in the Number of
Page 321 and 322: study, total drug expenditures did
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Page 325 and 326: In the dataset for mixed model anal
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Page 329 and 330: Table 5.14: Test Statistics for Ord
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Page 335 and 336: values in the dataset for the perce
Page 337 and 338: Increase in the allergy-related vis
Page 339 and 340: Table 5.18: Mixed Model Analysis fo
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Page 345 and 346: The Durbin-Watson statistic for thi
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untransformed values yielded differ
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Mixed Model Analysis with Transform
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Table 5.25: Untransformed Mixed Mod
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significant in both time periods (T
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The significant variables in this a
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in the drug expenditures for advert
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coefficient for this variable was 6
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years, 45-64 years, and 65 years an
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in time period one compared to time
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Table 5.34: Mixed Model Analysis fo
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every one percent increase in indiv
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less than 25 years, 25-44 years, 45
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significant relationships in both t
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visit {df=235, t=9.64, p
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variables in the equation. For ever
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for gastrointestinal-related visits
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In the absence of the visit variabl
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expenditures, and drug expenditures
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Table 5.46: Mixed Model Analyses fo
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untransformed variables were reconf
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Table 5.48: Test Statistics for Ord
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while controlling for other variabl
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1997 to April 2001), which categori
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antidepressants, the analysis was r
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variables in the equation. The perc
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The only age variable that was sign
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prescriptions written for advertise
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in time period two was not supporte
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with health insurance coverage had
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with the transformed variables (Tab
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prescription for advertised antidep
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significant variables indicating th
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antidepressants and were 65 years a
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Time series analysis was employed t
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Table 5.63: Test Statistics for Ord
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The results of the mixed model anal
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The significant variables in the an
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number of prescriptions written for
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elated visits, DTCA expenditures fo
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The interaction between DTCA expend
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An increase in number of hypertensi
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in the equation. In time period two
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200 and 360 outlets (spot markets),
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to three reasons for visits were re
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The access or health insurance cove
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• A wider use of the drugs may re
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Table 6.1: Results of the Hypothese
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Tables 6.3 and 6.4 provide a snapsh
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market and advertising of these dru
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(p=0.071). On splitting the dataset
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antidepressants and depression-rela
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The results for age should be inter
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Objective II: Hypotheses for the De
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Objective IV: Hypotheses for Depend
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For every $1,000 increase in DTCA e
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prescriptions written for antidepre
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were positively and significantly r
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coverage were more likely to be pre
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antihypertensives reduced drastical
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The upheavals in the market may be
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a result of advertising, patients m
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included in the study, inducing phy
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new prescriptions or rather are a r
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Objective III: Hypotheses for the D
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Objective IV: Hypotheses for the De
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DTCA ExpendituresSimilar to the rel
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expenditures and prescriptions writ
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expenditures for antihypertensives.
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also possible that individuals rece
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eported increased expenditures by a
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awareness for consumers and physici
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as well as number of prescriptions
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Some studies have reported that wom
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Physician VisitsPhysician visits (s
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individuals had a positive relation
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not only due to DTCA, but also othe
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should be repeated for these newer
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GLOSSARY OF ACRONYMSAARP - American
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Average Wholesale Price of Drugs, 1
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Total DTCA Expenditures (in million
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Number and Percentage of Prescripti
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Percentage of Women Among those who
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Appendix FTables for Percentage of
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Percentage of Individuals with Heal
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Number And Percentage Of Prescripti
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DrugCapoten®ToprolXL®Altace®Numb
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Appendix HFigures for Percentage of
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Percentage of Prescriptions Written
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Appendix ITables for Total Prescrip
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Total Prescription Drug Expenditure
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BIBLIOGRAPHY. 21 C.F.R. § 202.1(1)
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Direct-to-consumer advertisement of
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Health care in America: Trends in u
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Report to the President: Prescripti
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Angel JE. Drug advertisements and p
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Cain G. A remedy for rising drug co
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Eng HJ, Lairson DR. Prescribed medi
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Goldman DP, Joyce GF, Escarce JJ, e
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IMS-Health. Paper presented at: Pha
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Lipsky MS, Taylor CA. The opinions
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Morris LA, Mazis MB, Brinberg D. Ri
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Rosenbach ML, Irvin C, Coulam RF. A
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Smart S, Williams C. Half of drug a
Page 563 and 564:
Wind Y. Pharmaceutical advertising:
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