Patterns of Inheritance

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LE 9-8aDominant TraitsRecessive TraitsFrecklesNo frecklesWidow’s peakStraight hairlineFree earlobeAttached earlobeLE 9-8bDdJoshuaLambertDdAbigailLinnellD ?JohnEddyD ?HepzibahDaggettD ?AbigailLambertddJonathanLambertDdElizabethEddyDd Dd dd Dd Dd Dd ddPedigree ChartFemale MaleDeafHearing• Many inherited genetic disorders in humans arecontrolled by a single gene– Thousands of human genetic disorders follow simpleMendelian patterns of inheritance– These are medical conditions caused by eitherdominant or recessive alleles inherited from parents– Recessive and dominate alleles have different“patterns of inheritance”10
Autosomal Recessive disorders• Most genetic disorders• Can be carried unnoticed by heterozygotes (carriers)• Range in severity from mild (albinism) to severe(cystic fibrosis)• AA normal, unaffected; Aa carrier, unaffected; aaaffected• Affected child can have normal parents– Autosomal Dominant disorders• Some serious, but nonlethal, disorders• Aa or AA affected; aa normal• One or both parents affected; affected or normal child• Lethal conditions less common than in recessive disorders– Cannot be carried by heterozygotes without affecting them– Can be passed on if they do not cause death until later age(Huntington's disease)LE 9-9aParentsNormalDd×NormalDdSpermDdDDDNormalDdNormal(carrier)OffspringEggsdDdNormal(carrier)ddDeaf11
Page 1 and 2: Patterns of InheritanceWhat is inhe
Page 3 and 4: LE 9-2dFlower colorPurpleWhiteFlowe
Page 5 and 6: Homologous pair of chromosomesALLEL
Page 7 and 8: • Geneticists use the testcross t
Page 9: • Mendel's laws reflect the rules
Page 13 and 14: Incomplete DominanceR 1 R 1 R 1 R 2
Page 15 and 16: PUTTING IT ALL TOGETHER:Sickle-Cell
Page 17 and 18: THE CHROMOSOMAL BASISOF INHERITANCE
Page 19 and 20: • Geneticists use crossover data
Page 21: LE 9-24bQueenVictoriaAlbertAliceLou

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