92 Frequently Asked Questions on the New 510(K) Paradigm - Medtox

13C. Unrelated Compounds, Prescription and Over-the-Counter MedicationsThe following compounds were tested for reactivity to the SURE-SCREEN Drugs of Abuse Test System. Listed compounds were dissolved in appropriate solventsand then added to drug-free urine for testing. Samples were evaluated in triplicate by in-house operators. Unless otherwise noted by a drug name abbreviation suchas “AMP” or “BAR” etc., all of the listed compounds were negative in each of the tests at 100 µg/mL or the highest level tested. (Alprazolam, 1-hydroxy;Buprenorphine, Fentanyl, Lorazepam glucuronide, 11-Nor-9-carboxy- 9 -THC, Olanzapine, and Oxazepam glucuronide were evaluated at 10µg/mL. 11-Nor-9-carboxy- 8 -THC was evaluated at 5 µg/mL). If a drug name is followed by an abbreviation such as “AMP” or “BAR” etc., check the “Related Compounds and CrossReactants” listing for the drug in question under the appropriate heading (AMP, BAR, etc.) to find its level of cross-reactivity to that test.Acecainide (N-Acetaminophen Acetylsalicylic Acid Allobarbital-BAR Alphenal-BAR Alprazolam-BZOAcetylprocainamide)Alprazolam, 1-Hydroxy-BZOp-Aminobenzoic Acid 7-Amino-clonazepam 7-Amino-flunitrazepam Aminoglutethimide l-Aminopyrine (4-(dimethylamino) antipyrine)Amitriptyline Amobarbital-BAR Amoxapine Amoxicillin d-Amphetamine-AMP l- Amphetamine-AMPAmpicillin Apomorphine l-Ascorbic Acid Aspartame Atenolol Atropine SulfateBarbital-BAR Barbituric Acid Benzilic Acid Benzoic Acid Benzocaine (ethyl -4- Benzoylecgonine-COCaminobenzoate)Benzphetamine Benztropine Brompheniramine Buprenorphine-BUP Bupropion Butabarbital-BARButalbital-BAR Caffeine Cannabidiol Cannabinol Captopril CarbamazepineCarbamazepine-10,11 CarisoprodolCephalexin Chloral Hydrate Chloramphenicol Chlordiazepoxide-BZOepoxide(Meprobamate)Chloroquine Chlorothiazide Chlorpheniramine Chlorpromazine Chlorprothixene Clobazam-BZOClomipramine Clonazepam-BZO Clonidine Clorazepate-BZO Clozapine Cocaine-COCCodeine-OPI, OXY Cortisone Cotinine Cyclobenzaprine Cyclopentobarbital-BARDeoxycorticosteroneDesalkylflurazepam-BZODesipramineDesmethylchlordiazepoxide (Norchlordiazepoxide)-BZODesmethylflunitrazepam-BZODesmethylvenlafaxineDexamethasoneDextromethorphan Diacetylmorphine-OPI Diazepam-BZO Diclofenac Diethylpropion DiflunisalDigoxinDihydrocodeine-OPI, Dimenhydrinate1,3-Dimethylbarbituric acid Diphenhydramine DomperidoneOXY(Dramamine)Dopamine Doxepin Doxylamine Ecgonine Ecgonine Methyl Ester EDDP (Primary metabolite ofmethadone)Efavirenz (Sustiva) EMDP (SecondaryEphedrine-MAMP Equilin Erythromycin Estronemetabolite of methadone)-Ethanol Ethylmorphine-OPI, OXY Fenfluramine-MAMP Fenoprofen Fentanyl (Synthetic Flunitrazepam-BZOopiate)Fluoxetine (Prozac) Flurazepam Furosemide Fluvoxamine Gentisic Acid (2,5- GlutethimideDihydroxybenzoic acid)Guaiacol Glyceryl Haloperidol Hexobarbital Hippuric acid Hydralazine HydrochlorothiazideEtherHydrocodone-OPI, HydrocortisoneHydromorphone-OPI, Hydroxybupropion Hydroxyhippuric acid l-11-Hydroxy- 9 -THC-THCOXYOXYp-4-Hydroxyphencyclidine- 3-Hydroxytyramine Hydroxyzine Ibuprofen ImipramineHydroxyphenobarbital-BARPCPIproniazid (R)-Isoproterenol Isoxsuprine Ketamine Ketoprofen LabetalolLevorphanol-OPI Lidocaine Lithium carbonate Loperamide Lorazepam-BZO Lorazepam glucuronide-BZOLoxapine Lysergic Acid-BZO Lysergic AcidMaprotiline MDA-AMP MDE (MDEA)-MAMPDiethylamide (LSD)MDMA-MAMP Melanin Meperidine Mephobarbital Mepivacaine MesoridazineMethadone-MTD d-Methamphetamine- l-Methamphetamine- Methaqualone Methcathinone MethocarbamolMAMPMAMPMethoxyphenamine Methylphenidate Methylprylon Metoprolol Midazolam-BZO Mirtazapine6-Monoacetylmorphine-OPIMorphine-OPI, OXYMorphine 3--D-Glucuronide-OPIMorphine 6--D-GlucuronideNalidixic AcidNaltrexone- OXYNalorphine-OPI Naloxone-OPI, OXY Naproxen Niacinamide Nicotine NifedipineNitrazepam-BZO Nitrofurantoin Norclomipramine Norcodeine- OXY Nordiazepam--BZO NordoxepinNorethindrone Norlysergic Acid Normeperidine Norpropoxyphene-PPX l-Norpseudoephedrine 11-Nor-9-carboxy- 9 -THC -THC11-Nor-9-carboxy- 8 - Nortriptyline Noscapine Nylidrin Octopamine Ofloxacin- OPITHC-THCOlanzapine (Zyprexa)- Omeprazole Orphenadrine Oxalic Acid Oxaprosin Oxazepam-BZOTCA positive-Anti-PsychoticOxazepamOxolinic Acid Oxycodone-OPI, OXY Oxymetazoline Oxymorphone-OPI, Papaverine hydrochlorideglucuronide-BZOOXYPentazocine Pentobarbital-BAR Perphenazine PhenacetinPhencyclidine-PCP(Acetophenetidin)Phendimetrazine Phenelzine Phenethylamine- MAMP Pheniramine Phenmetrazine Phenobarbital-BARPhenothiazine Phentermine- AMP PhenytoinPhenylbutazone Phenylephrine-MAMP Phenylpropanolamine(Diphenylhydantoin)-BARPiroxicam Prazosin Prednisolone Prednisone Procaine- MAMP ProcainamideProchlorperazine Promazine Promethazine Propoxyphene-PPX Propranolol ProtriptylinePseudoephedrine Pyrilamine Quetiapine (Seroquel)- Quinidine Ranitidine RiboflavinTCA positive-Anti-PsychoticRifampin Salicylic Acid Secobarbital-BAR Selegiline (Deprenyl) Serotonin (5-Sertraline (Zoloft)Hydroxytryptamine)Sildenafil (Viagra) Sulfamethazine Sulindac Talbutal-BAR Temazepam-BZO Temazepam glucuronide-BZOTetracycline 9 -Tetrahydrocannabinol- 8 -Tetrahydrocannabinol- TetrahydrozolineThebaine-OPITHC( 6 -Tetrahydrocannabinol)THCTheophyline Thiamine Thiopental Thioridazine Thiothixene TolbutamidePage 8 of 11