13C. Unrelated Compounds, Prescripti<strong>on</strong> and Over-<strong>the</strong>-Counter Medicati<strong>on</strong>sThe following compounds were tested for reactivity to <strong>the</strong> SURE-SCREEN Drugs of Abuse Test System. Listed compounds were dissolved in appropriate solventsand <strong>the</strong>n added to drug-free urine for testing. Samples were evaluated in triplicate by in-house operators. Unless o<strong>the</strong>rwise noted by a drug name abbreviati<strong>on</strong> suchas “AMP” or “BAR” etc., all of <strong>the</strong> listed compounds were negative in each of <strong>the</strong> tests at 100 µg/mL or <strong>the</strong> highest level tested. (Alprazolam, 1-hydroxy;Buprenorphine, Fentanyl, Lorazepam glucur<strong>on</strong>ide, 11-Nor-9-carboxy- 9 -THC, Olanzapine, and Oxazepam glucur<strong>on</strong>ide were evaluated at 10µg/mL. 11-Nor-9-carboxy- 8 -THC was evaluated at 5 µg/mL). If a drug name is followed by an abbreviati<strong>on</strong> such as “AMP” or “BAR” etc., check <strong>the</strong> “Related Compounds and CrossReactants” listing for <strong>the</strong> drug in questi<strong>on</strong> under <strong>the</strong> appropriate heading (AMP, BAR, etc.) to find its level of cross-reactivity to that test.Acecainide (N-Acetaminophen Acetylsalicylic Acid Allobarbital-BAR Alphenal-BAR Alprazolam-BZOAcetylprocainamide)Alprazolam, 1-Hydroxy-BZOp-Aminobenzoic Acid 7-Amino-cl<strong>on</strong>azepam 7-Amino-flunitrazepam Aminoglutethimide l-Aminopyrine (4-(dimethylamino) antipyrine)Amitriptyline Amobarbital-BAR Amoxapine Amoxicillin d-Amphetamine-AMP l- Amphetamine-AMPAmpicillin Apomorphine l-Ascorbic Acid Aspartame Atenolol Atropine SulfateBarbital-BAR Barbituric Acid Benzilic Acid Benzoic Acid Benzocaine (ethyl -4- Benzoylecg<strong>on</strong>ine-COCaminobenzoate)Benzphetamine Benztropine Brompheniramine Buprenorphine-BUP Bupropi<strong>on</strong> Butabarbital-BARButalbital-BAR Caffeine Cannabidiol Cannabinol Captopril CarbamazepineCarbamazepine-10,11 CarisoprodolCephalexin Chloral Hydrate Chloramphenicol Chlordiazepoxide-BZOepoxide(Meprobamate)Chloroquine Chlorothiazide Chlorpheniramine Chlorpromazine Chlorprothixene Clobazam-BZOClomipramine Cl<strong>on</strong>azepam-BZO Cl<strong>on</strong>idine Clorazepate-BZO Clozapine Cocaine-COCCodeine-OPI, OXY Cortis<strong>on</strong>e Cotinine Cyclobenzaprine Cyclopentobarbital-BARDeoxycorticoster<strong>on</strong>eDesalkylflurazepam-BZODesipramineDesmethylchlordiazepoxide (Norchlordiazepoxide)-BZODesmethylflunitrazepam-BZODesmethylvenlafaxineDexamethas<strong>on</strong>eDextromethorphan Diacetylmorphine-OPI Diazepam-BZO Diclofenac Diethylpropi<strong>on</strong> DiflunisalDigoxinDihydrocodeine-OPI, Dimenhydrinate1,3-Dimethylbarbituric acid Diphenhydramine Domperid<strong>on</strong>eOXY(Dramamine)Dopamine Doxepin Doxylamine Ecg<strong>on</strong>ine Ecg<strong>on</strong>ine Methyl Ester EDDP (Primary metabolite ofmethad<strong>on</strong>e)Efavirenz (Sustiva) EMDP (Sec<strong>on</strong>daryEphedrine-MAMP Equilin Erythromycin Estr<strong>on</strong>emetabolite of methad<strong>on</strong>e)-Ethanol Ethylmorphine-OPI, OXY Fenfluramine-MAMP Fenoprofen Fentanyl (Syn<strong>the</strong>tic Flunitrazepam-BZOopiate)Fluoxetine (Prozac) Flurazepam Furosemide Fluvoxamine Gentisic Acid (2,5- GlutethimideDihydroxybenzoic acid)Guaiacol Glyceryl Haloperidol Hexobarbital Hippuric acid Hydralazine HydrochlorothiazideE<strong>the</strong>rHydrocod<strong>on</strong>e-OPI, Hydrocortis<strong>on</strong>eHydromorph<strong>on</strong>e-OPI, Hydroxybupropi<strong>on</strong> Hydroxyhippuric acid l-11-Hydroxy- 9 -THC-THCOXYOXYp-4-Hydroxyphencyclidine- 3-Hydroxytyramine Hydroxyzine Ibuprofen ImipramineHydroxyphenobarbital-BARPCPIpr<strong>on</strong>iazid (R)-Isoproterenol Isoxsuprine Ketamine Ketoprofen LabetalolLevorphanol-OPI Lidocaine Lithium carb<strong>on</strong>ate Loperamide Lorazepam-BZO Lorazepam glucur<strong>on</strong>ide-BZOLoxapine Lysergic Acid-BZO Lysergic AcidMaprotiline MDA-AMP MDE (MDEA)-MAMPDiethylamide (LSD)MDMA-MAMP Melanin Meperidine Mephobarbital Mepivacaine MesoridazineMethad<strong>on</strong>e-MTD d-Methamphetamine- l-Methamphetamine- Methaqual<strong>on</strong>e Methcathin<strong>on</strong>e MethocarbamolMAMPMAMPMethoxyphenamine Methylphenidate Methylpryl<strong>on</strong> Metoprolol Midazolam-BZO Mirtazapine6-M<strong>on</strong>oacetylmorphine-OPIMorphine-OPI, OXYMorphine 3--D-Glucur<strong>on</strong>ide-OPIMorphine 6--D-Glucur<strong>on</strong>ideNalidixic AcidNaltrex<strong>on</strong>e- OXYNalorphine-OPI Nalox<strong>on</strong>e-OPI, OXY Naproxen Niacinamide Nicotine NifedipineNitrazepam-BZO Nitrofurantoin Norclomipramine Norcodeine- OXY Nordiazepam--BZO NordoxepinNorethindr<strong>on</strong>e Norlysergic Acid Normeperidine Norpropoxyphene-PPX l-Norpseudoephedrine 11-Nor-9-carboxy- 9 -THC -THC11-Nor-9-carboxy- 8 - Nortriptyline Noscapine Nylidrin Octopamine Ofloxacin- OPITHC-THCOlanzapine (Zyprexa)- Omeprazole Orphenadrine Oxalic Acid Oxaprosin Oxazepam-BZOTCA positive-Anti-PsychoticOxazepamOxolinic Acid Oxycod<strong>on</strong>e-OPI, OXY Oxymetazoline Oxymorph<strong>on</strong>e-OPI, Papaverine hydrochlorideglucur<strong>on</strong>ide-BZOOXYPentazocine Pentobarbital-BAR Perphenazine PhenacetinPhencyclidine-PCP(Acetophenetidin)Phendimetrazine Phenelzine Phenethylamine- MAMP Pheniramine Phenmetrazine Phenobarbital-BARPhenothiazine Phentermine- AMP PhenytoinPhenylbutaz<strong>on</strong>e Phenylephrine-MAMP Phenylpropanolamine(Diphenylhydantoin)-BARPiroxicam Prazosin Prednisol<strong>on</strong>e Prednis<strong>on</strong>e Procaine- MAMP ProcainamideProchlorperazine Promazine Promethazine Propoxyphene-PPX Propranolol ProtriptylinePseudoephedrine Pyrilamine Quetiapine (Seroquel)- Quinidine Ranitidine RiboflavinTCA positive-Anti-PsychoticRifampin Salicylic Acid Secobarbital-BAR Selegiline (Deprenyl) Serot<strong>on</strong>in (5-Sertraline (Zoloft)Hydroxytryptamine)Sildenafil (Viagra) Sulfamethazine Sulindac Talbutal-BAR Temazepam-BZO Temazepam glucur<strong>on</strong>ide-BZOTetracycline 9 -Tetrahydrocannabinol- 8 -Tetrahydrocannabinol- TetrahydrozolineThebaine-OPITHC( 6 -Tetrahydrocannabinol)THCTheophyline Thiamine Thiopental Thioridazine Thiothixene TolbutamidePage 8 of 11
Tolmetin (Tolectin) Trazod<strong>on</strong>e Triamterene Triazolam-BZO Triazolam, 1-hydroxy TrifluoperazineTrimethoprim Trimipramine Tripelennamine Tryptamine Tryptophan TyramineTyrosine Valproic Acid Venlafaxine Verapamil Zomepirac13D. Related and Reactive CompoundsThe following metabolites and reacting compounds were evaluated for <strong>the</strong> specified test <strong>on</strong> <strong>the</strong> SURE-SCREEN Drugs of Abuse Test System. Reference standardsfor <strong>the</strong> various metabolites and compounds were prepared in negative urine samples. Results are expressed as <strong>the</strong> minimum c<strong>on</strong>centrati<strong>on</strong> expected to produce apositive result in <strong>the</strong> indicated assay. Compounds that reacted with <strong>the</strong> test are listed first, and related compounds that did not react with <strong>the</strong> highest c<strong>on</strong>centrati<strong>on</strong>tested are listed sec<strong>on</strong>d as Negative at 100,000 ng/mL (or highest level tested).Amphetamines- (AMP) (d-Amphetamine) 300 ng/mL Result % Cross-Reactivel-Amphetamine Positive at 100,000 ng/mL
Change language