PAULA J. GAREAU Contact Information EDUCATION/TRAINING ...

June 18, 2002PAULA J. GAREAUCurriculum VitaeContact Information Business Address: Imaging Research laboratoriesThe John P. Robarts ResearchInstituteP.O. Box 5015, 100 Perth DriveLondon, Ontario, Canada N6A 5K8Telephone: 519/663-5777, ext. 34040/34133Fax: 519/663-3078E-mail:pgareau@irus.rri.caWebsite:http://www.irus.rri.ca/~pgareauEDUCATION/TRAININGSeptember 1986 - December 1990January 1991 - March 1993September 1994 - April 1997March 1997 - June 1999BSc (Hons)Department of Human BiologyUniversity of GuelphMScDepartment of Clinical StudiesUniversity of GuelphSupervisor: Dr. Edward JanzenPhDDepartment of Biomedical StudiesUniversity of GuelphSupervisor: Drs. Bill Harris and Edward JanzenPostdoctoral FellowshipDepartment of Diagnostic Radiology & Nuclear MedicineThe University of Western OntarioSupervisor: Dr. R. MitchellPROFESSIONAL EXPERIENCEJuly 1, 1999 - June 30, 2000Research AssociateImaging Research LaboratoriesThe John P. Robarts Research InstituteSupervisor: Dr. B. Rutt

Gareau, Paula June 18, 2002Project Role:Principal InvestigatorAmount requested: $73,000 / one yearFor the Period: September 1, 2000 - August 31, 2001Agency/Program: US Army Medical Materiel, Breast Cancer Research ProgramProject Title:Prediction of Malignancy in Breast Tumors Using DiffusionWeighted MRI (# 9919227)Project Role:Principal InvestigatorAmount requested: $42,000 / one yearFor the Period: July 1, 1999 - June 2001PUBLICATIONSRefereed Papers: Published/In Press11. Gareau PJ, Wymore AC, Cofer GP, and Johnson GA. Imaging inflammation: directvisualization of perivascular cuffing in EAE by magnetic resonance microscopy. Journal ofMagnetic Resonance Imaging: Accepted March 25, 2002.10. Bowen CV, Zhang X. Saab G, Gareau PJ, and Rutt BK. Application of static dephasingregime theory to superparamagnetic iron-oxide loaded cells. Magnetic Resonance inMedicine: Accepted February 25, 2002.9. Gareau P, Wymore, AC, Cofer GP, and Johnson, GA. Imaging inflammation: directvisualization of perivascular cuffing in EAE by magnetic resonance microscopy. Journal ofMagnetic Resonance Imaging 16: 28-36, 2002.8. Gareau PJ, Weaver LC, and Dekaban GA. In vivo magnetization transfer ratios inexperimental spinal cord injury in the rat. Magnetic Resonance in Medicine 45: 159-163,2001.7. Gareau PJ, Rutt BK, Karlik SJ, and Mitchell JR. Magnetization transfer ratios andmulticomponent T2 relaxation measurements with histopathologic correlation in anexperimental model of MS. Journal of Magnetic Resonance Imaging 11: 586-595, 2000.6. Gareau PJ, Rutt BK, Bowen CV, Karlik SJ, and Mitchell JR. In vivo measurements ofmulti-component T2 relaxation behavior in guinea pig brain. Magnetic ResonanceImaging 17: 1319-1325, 1999.5. Gareau PJ, Gati JS, Menon RS, Lee D, Rice G, Mitchell JR, Mandelfino P, and Karlik SJ.Reduced visual evoked responses in multiple sclerosis patients with optic neuritis:comparison of functional magnetic resonance imaging and visual evoked potentials.Multiple Sclerosis 5: 161-164, 1999.4. Foster WG, Ruka MP, Gareau P, Foster RA, Janzen EG and Yang JZ. Morphologiccharacteristics of endometriosis in the mouse model: application to toxicology. CanadianJournal of Physiology and Pharmacology 75: 1188-1196 1997.- 4 -

Gareau, Paula June 18, 20023. Janzen EG, Gareau PJ, Stewart WA and Towner RA. The use of in vivo MRI and MRS tostudy porcine stress syndrome in young halothane susceptible pigs. Canadian Journal ofAnimal Science 74: 37-43, 1994.2. Janzen EG and Gareau PJ. In vivo proton magnetic resonance imaging of liver in youngpigs exposed to halothane. Comparison between normal and stress-susceptible pigs. LifeSciences Advances 12: 93-98 1993.1. Gareau PJ, Janzen EG, Towner RA and Stewart WA. In vivo P-31 spectroscopy studies ofhalothane-induced porcine stress syndrome,. No effect of C phenyl-N-tert-butyl nitrone(PBN). Free Radical Research Communications 19: 43-50, 1993.Conference Proceedings and Abstracts17. Zhang X, Bowen CV, Gareau PJ, and Rutt BK. “Quantitative analysis of SPIO andUSPIO uptake rate by macrophages: effects of particle size, concentration, and labelingtime”. International Society for Magnetic Resonance in Medicine, #880, Glasgow,Scotland: April 20-27, 2001.16. Rutt BK, Gareau PJ, and Friesen-Waldner L. “Quantitative microvascular breast MRI”.Proceedings of the Second International Congress on MR Mammography, Eur Radiol. 10:F39, 2000.15. Gareau PJ, Weaver LC, and Dekaban GA. “ Longitudinal in vivo magnetization transferratios in experimental spinal cord injury”. Proceedings of the 8 th International Society forMagnetic Resonance in Medicine, #2150, Denver, Colorado, USA: April 1-7, 2000.14. Gareau PJ, Rutt BK, Karlik SJ, and Mitchell JR. “Magnetization transfer ratios ininflammatory brain disease”. Proceedings of the 8 th International Society for MagneticResonance in Medicine, #1178, Denver, Colorado, USA: April 1-7, 2000.13. Holmes SP, Thornton M, Gareau PJ, Rutt BK, and Holdsworth DW. “Delineation of anacquisition window within the respiratory cycle of laboratory animals”. High ResolutionImaging of Small Animals with PET, Ultrasound and MR, Amsterdam, The Netherlands:September 27-19, 1999.12. Karlik SJ, Gareau PJ, Rutt BK, Mitchell JR, and Hammond R. “Pathological changesunderlying decreased magnetization transfer measurements”. Proceedings of ECTRIMS,Basel, Switzerland: September, 1999.11. Gareau PJ, Mitchell JR, Karlik SJ, and Rutt BK. “CPMG imaging at 4.0 Tesla forestimation of multi-component T2 relaxation in vivo”. Proceedings of the 44 th AnnualMeeting of the Canadian Organization of Medical Physicists, #160, London, Ontario,Canada: June 18-20, 1998.10. Gareau PJ, Bowen CV, Mitchell JR, Karlik SJ, and Rutt BK. “An optimized CPMGimaging sequence for multi-component T2 measurements at 4.0T”. Proceedings of the 44 thAnnual Meeting of the Canadian Organization of Medical Physicists, #163, London,Ontario, Canada: June 18-20, 1998.9. Gareau PJ, Mitchell JR, Karlik SJ, and Rutt BK. “Multi-component T2 analysis usingCPMG at 4.0 Tesla”. Proceedings of the 6 th International Society for Magnetic Resonancein Medicine, #1340, Sydney, Australia: April 18-24, 1998.- 5 -

Gareau, Paula June 18, 20028. Gareau PJ, Mitchell JR, Karlik SJ, and Rutt BK. “In vivo multi-component T2 relaxationof normal guinea pig brain at 1.5T and 4.0T”. Proceedings of the 6 th International Societyfor Magnetic Resonance in Medicine, #1339, Sydney, Australia: April 18-24, 1998.7. Gareau PJ, Reinke LA, and Janzen EG. “Kupffer cell inhibition reverses the MRIdetectablesigns of chemically-induced liver damage in rats”. Proceedings of the 5 thInternational Society for Magnetic Resonance in Medicine, #932: Vancouver, BritishColumbia, Canada: April 12-18, 1997.6. Gareau PJ and Janzen EG. “An MRI study of the activity of toxic liver injury in rats”.Proceedings of the 5 th International Society for Magnetic Resonance in Medicine, #931,Vancouver, British Columbia, Canada: April 12-18, 1997.5. Ruka MP, McCutheon JL, Gareau PJ, Foster WG, and Janzen EG. “Surgically-inducedmodel of endometriosis in B6C3F1 mice”. Proceedings of the 1995 Annual Meeting of theRoyal College of Physicians and Surgeons of Canada, Montreal, Quebec, Canada:September 13-17, 1995. Clinical and Investigative Medicine, suppl. 1(4): 713, 1995.4. Ruka MP, McCutheon JL, Gareau PJ, Foster WG, and Janzen EG. “Evaluation ofestrogen/progesterone treatment on the functional integrity of the endometrium temporallyexposed to warm ischemia prior to its autotransplantation”, Proceedings of the 1995Annual Meeting of the Royal College of Physicians and Surgeons of Canada, Montreal,Quebec, Canada”: September 13-17, 1995. Clinical and Investigative Medicine, suppl.1(4): 723, 1995.3. Bahr RJ, Hurtig MB, Dobson H, Ewing KK, and Gareau PJ. “MR imaging of in vivonormal and acutely septic equine fetlock joints”. Proceedings of the 10 th Meeting of theInternational Radiology Association, Philadelphia, Pennsylvania, USA: August 1-6, 1994.2. Chen JZ, Janzen EG, Gareau PJ, Reinke LA, and Oehler UM. “Hepatotoxicity ofchloroform and methylene chlroide in rat studied by MRI and EPR spin trapping”.Proceedings of the 4 th International Symposium on Spin Trapping and Organic EPRSpectroscopy with Applications in Chemistry, Biology and Medicine, Oklahoma City,Oklahoma, USA: Otober 24-28, 1993.1. Gareau PJ, Ruka MP, Reinke LA, Butler D, and Janzen EG. “The use of MRI and spintrapping to study CCl4-induced hepatotoxicity in rats implemented with Guyton’s sphere”.Proceedings of the 4 th International Symposium on Spin Trapping and OrganicEPR.Spectroscopy with Applications in Chemistry, Biology and Medicine, Oklahoma City,Oklahoma, USA: October 24-28, 1993.Invited Talks:7. Gareau, PJ. Micro- and Cellular-Imaging Using MRI. The Centre for Vascular ImagingResearch Seminar Series, The John P. Robarts Research Institute, London, Ontario,Canada: February 19, 2002.6. Gareau, PJ. Cellular Imaging. Center for In Vivo Microscopy Seminar Series, DukeUniversity Medical Center, Durham, North Carolina, USA: February 1, 2002.- 6 -

Gareau, Paula June 18, 20025. Gareau PJ, Chen YT, and Rutt BK. Micromaging at 1.5 Tesla. The Center for In VivoMicroscopy Seminar Series, Duke University Medical Center, Durham, North Carolina,USA: November 29, 2001.4. Gareau PJ, Wymore AC, Cofer GP, Karlik SJ, and Johnson GA. Imaging inflammation:direct visualization of perivascular cuffing in EAE by magnetic resonance microscopy.The 9 th International Society for Magnetic Resonance in Medicine, Glasgow, Scotland:April 23, 2001.3. Gareau PJ. Rutt BK, Karlik SJ, and Mitchell JR. Magnetization transfer ratios and multicomponentT2 relaxation measurements in an experimental model of MS. 8 th Meeting ofthe International Society for Magnetic Resonance in Medicine, #228, Denver, Colorado,USA: April 1-7, 2000.2. Gareau PJ, Mitchell JR, Rutt BK, and Karlik SJ. Magnetization transfer measurementswith histopathologic correlation in an experimental model of multiple sclerosis. 7 thMeeting of the International Society for Magnetic Resonance in Medicine, #631,Philadelphia, Pennsylvania, USA: May 22-28, 1999.1. Gareau PJ, Mitchell JR, Gati JS, Menon RS, and Karlik SJ. Reduced BOLD fMRI signalchanges in the primary visual cortex of MS patients with unilateral optic neuritis:correlation with visual evoked potentials. 7 th Meeting of the International Society forMagnetic Resonance in Medicine, #502, Philadelphia, Pennsylvania, USA: May 22-28,1999.- 7 -