PCOS: Laparoscopic Laparoscopic ovarian drilling or ... - eshre
PCOS: Laparoscopic Laparoscopic ovarian drilling or ... - eshre
PCOS: Laparoscopic Laparoscopic ovarian drilling or ... - eshre
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High level of LeptinLeptin is a Protein of the ob gene (chromosom 7 )secreted from adipocytes thatregulates at the central level thefood intakeDiscrepancy between elevatedleptin and its central actionsupp<strong>or</strong>t the concept that obesityis a Leptin resistance conditionRedroductive Target <strong>or</strong>gansare hypothalamus, ovary andendometriumIt regulates the gonadotropinssurge that starts pubertaldevelopmentSeems to affect steroidogenesison follicular cellsInsulin resistance andHyperinsulinemiaFrequent in abdominal obesitywith hyperandrogenemia:Insuline stimulates Androgenproduction ?Androgens promotes IR?Contrary to what occur inother tissues, the ovaryremains responsive toinsulin andhyperinsulinemia is a keyfact<strong>or</strong> f<strong>or</strong> excess androgenproduction by the thecacells
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