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Cocaine.Conclusions1. Cold-blooded animals (Frogs) are more sensitive tococaine than warm-blooded animals. Among the latter,carnivores manifest a greater sensitivity thanherbivores.2. Cocaine acts principally on the central nervoussystem.3. In the frog (Rana temporaria and R. esculenta)cocaine paralyses the nerve endings and the nervecenters, and the sensory nerve endings are the firstto be affected. Reflexes are first diminished andthen completely paralyzed.The increased reflex excitability observed withsmall doses appears to vary with the individual.(Anrep lists fourteen additional conclusions from theexperiments in the body of the paper, concerning the effectsof systemic cocaine on respiration, circulation, striatedmuscle, the pupil, intestinal motility, temperature, mucoussecretions, and, finally, respiratory paralysis, and ends asfollows:)After studying the physiological action of cocainein animals I had intended to investigate it also in man.Various other activities have so far prevented me from doingso. Although the experiments on animals have not had anypractical consequences I would recommend that cocaine betested as a local anesthetic and in melancholia.