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FLT-3 Ligand (ng/L)3 5003 0002 5002 0001 5001 00015 Gy PBI 30%10 Gy 50% PBI6.25 Gy PBI 80%5.55 Gy PBI 90%7.5 Gy / 2.5 Gy TBI5 Gy TBI2.5 Gy TBI50000 2 4 7 14 21 35 64 119 201Days after irradiationFlt-3 ligand level
Bone marrow assessment• Hematopoietic progenitors (CFU)Dose dependentdecrease inexposed areasstart ofrecoveryOverall completerecovery0 1 D 42 D200 D• Multi-site sampling of CD34 + cells: early indicatorof inhomogeneous exposure
Page 1 and 2: A multiparameter approach to assest
Page 3 and 4: A study designed to account for acc
Page 5 and 6: Multiparameter approach (>50)• Cl
Page 7 and 8: Statistical analysis: PLS-DA• Sof
Page 9 and 10: Dicentric assay (day 1)1,42.5 Gy TB
Page 11 and 12: Hematology
Page 13: 140Platelet count (% of baseline)12
Page 17 and 18: CRP (mg/L)1201008060405 Gy TBI10 Gy
Page 19 and 20: What about other early bioindicator
Page 21: AcknowledgmentsIRBA / CRSSA• Marc

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