day 1 - Bsbb

Rationale• The use of IND and RED by terrorists would lead to anunpredictable ratio of TBI and PBI.• The DCA alone may not distinguish TBI (requiring specifichematologic support) and PBI with low level of BMshielding (spontaneous recovery likely to be expected).• PBI studies in mice suggest that the site of exposuredictates the biologic response (Meadows 2010), but– malevolent exposures would not be organ-targeted– human response to radiation is characterized by anintrinsic heterogeneity (corpulence) not seen in mice• à There is a need of relevant biomarkers of heterogeneityand injury for PBI versus TBI (diagnosis and prognosis),also usable for late disclosed radiation accidents.