Domain 1Preventing people from dyingprematurelyIndicator Structure1.1 Domain 1, Preventing people from dying prematurely, comprises two overarchingindicators and seven improvement areas, summarised below.Overarching indicators1a Potential Years of Life Lost (PYLL) from causes considered amenable to healthcare i Adults ii Children and Young people1b Life expectancy at 75 i males ii femalesImprovement areasReducing premature mortality from the major causes of death1.1 Under 75 mortality rate from cardiovascular disease1.2 Under 75 mortality rate from respiratory disease1.3 Under 75 mortality rate from liver disease1.4 Under 75 mortality from canceri One and ii Five -year survival from all cancers1.4.iii One and iv Five-year survival from breast, lung and colorectal cancerReducing premature death in people with serious mental illness1.5 Excess under 75 mortality rate in adults with serious mental illnessReducing deaths in babies and young children1.6.i Infant mortality ii Neonatal mortality and stillbirths iii Five-year survival from allcancers in childrenReducing premature death in people with learning disabilities1.7 Excess under 60 mortality in people with learning disabilitiesDomain 11.2 <strong>The</strong> overarching indicators cover Potential Years of Life Lost from causes consideredamenable to healthcare, and life expectancy at 75.1.3 Deaths from causes considered ‘amenable’ to health care (as defined for indicators1a.i and ii below) are premature deaths that should not occur in the presence of timelyand effective health care. <strong>The</strong>se indicators have been chosen to capture howsuccessfully the <strong>NHS</strong> is meeting its objective to prevent people from dyingprematurely where it can make a difference. With the exception of a very smallnumber of deaths at age 75 and over, indicators 1a.i and ii cover the ages 0-74because it is generally considered that most premature deaths occur in this agegroup, and because it is more difficult to determine the cause of death in older peoplebecause they often have multiple co-morbidities. However, to ensure that the <strong>NHS</strong> isheld to account for doing all that it can to prevent avoidable deaths in older people,Life Expectancy at 75 is included as a second overarching indicator in this domain.This indicator captures all deaths at ages 75 and over.6
1.4 <strong>The</strong> improvement areas are of two sorts:• Sub-indicators. Indicators which are wholly or substantially covered by theoverarching indicators. Indicators 1.1, 1.2 and 1.4 relate to under 75 mortalityfrom major diseases – CVD, respiratory diseases and cancer. <strong>The</strong>se account foraround 90% of the disease burden amenable to health care. Cancer survival isincluded to capture the success of the <strong>NHS</strong> in preventing people of all ages fromdying of cancer once they have been diagnosed with the condition. Trends inthese outcomes, therefore, provide a useful initial analysis of what accounts forprogress in the overarching indicators. Amenable outcomes under indicators 1.5and 1.7, excess mortality rate in adults respectively with serious mental illnessand with a learning disability, are also largely captured in overarching indicator1a. In this case, the reason for inclusion of separate indicators is concern thatpoor outcomes for these groups may reflect inequity.• Complementary Indicators. Liver disease other than Hepatitis C is not countedas amenable under the ONS definition, and neonatal mortality up to the age of28 days is not included in indicator 1a because cause of death is not classifiedby ICD-10 code for deaths up to 28 days after live birth. Yet many deaths up to28 days and stillbirths, and some elements of liver mortality are amenable tohealthcare. <strong>The</strong>refore indicators 1.3 and 1.6.ii. complement the overarchingindicators.1.5 Not all of the deaths under 75 from the major diseases are counted as amenable –only 77% of CVD, 27% of respiratory disease, 23% of cancer and 2% of liver diseasedeaths are reckoned amenable. However, the <strong>NHS</strong> also contributes to reducingpremature deaths from causes not considered amenable. <strong>The</strong> inclusion of the under75 mortality indicators and infant mortality, all shared with the Public Health <strong>Outcomes</strong><strong>Framework</strong>, reflects the contribution that the <strong>NHS</strong> can make to outcomes where thereis shared responsibility with Public Health. <strong>The</strong> <strong>NHS</strong> contribution will includeencouraging healthy behaviours and uptake of screening and vaccination options, inaddition to providing appropriate diagnosis, care planning and treatment.1.6 Together, the overarching indicators and the improvement indicators provide a pictureof the <strong>NHS</strong>’s contribution to preventing people from dying prematurely.Work in Progress1.7 <strong>The</strong> main issues pertaining to Domain 1 upon which work is continuing are:• In the short term, replacement of existing cancer survival measures with aggregatesurvival measures respectively for all cancers in adults and children and for majorcancers (colorectal, breast and lung) in adults, to allow for disaggregation by CCG, andto include rarer cancers. Over a longer period, work with the cancer registries to obtaindata on the stage of disease at which patients are diagnosed, so as to control forsources of bias in estimates of survival. Initial work with data from a number of cancerregistries is in progress to estimate the percentage of cancers diagnosed and theirsurvival rates at each stage. (Indicator 1.4)7