Production Scale Kromaton Brochure - Rousselet Robatel
Production Scale Kromaton Brochure - Rousselet Robatel
Production Scale Kromaton Brochure - Rousselet Robatel
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PARAMETERS<br />
Column volume FCPC ® 200 ml FCPC ® 5000 ml<br />
Flow-rate 5 ml / min 58 ml / min<br />
rotation speed 1400 rpm 800 rpm<br />
quantity injected 1 gr 25 gr<br />
fraction analysis HPLC C18 at 220 nm<br />
APPLICATION<br />
<strong>Scale</strong> up on peptide purification from bench scale FCPC ® 200<br />
to pilot scale FCPC ® 5000<br />
mAU<br />
1500<br />
1000<br />
500<br />
0<br />
IMPURITIES<br />
0 10 20 30 40 50<br />
Minutes<br />
HPLC of crude mixture<br />
complete<br />
automatic<br />
line<br />
Source : <strong>Kromaton</strong> R&D Laboratory<br />
MAIN PEPTIDE<br />
PUMPS (SOLVENT & SAMPLE)<br />
MAIN PEPTIDE<br />
IMPURITIES<br />
IMPURITIES<br />
France<br />
9, rue alexandre fleming<br />
49066 Angers<br />
Phone : +33 241 77 41 48<br />
KROMATON@KROMATON.COM<br />
mAU<br />
1000<br />
FCPC ® chromatogram of peptide purification<br />
PC<br />
500<br />
0<br />
0 10<br />
20 30 40<br />
Minutes<br />
50 60<br />
HPLC of peptide (green zone) after FCPC ® purification<br />
IMPURITIES<br />
usa<br />
448 ignacio blvd. #480<br />
novato, ca 94949<br />
www.kromaton.com<br />
KROMATON-USA@KROMATON.COM<br />
MAIN PEPTIDE<br />
Column volume<br />
RESULTS<br />
FCPC ® 200 ml FCPC ® 5000 ml<br />
Solvent consumption 0,7 liter 19 liters<br />
Peptide collected 220 mg at 95% 5132 mg at 90%<br />
FCPC ® 5000 allows to purify peptide from synthetic mixture<br />
with low production cost and high purity recovery<br />
UV DETECTOR<br />
for your<br />
production<br />
needs<br />
FRACTION COLLECTOR<br />
Patent : fr 02791578 A1, US : 6537452, patent applic EP : 009122786 - FCPC ® is a <strong>Kromaton</strong> ® registered trademark
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