CURRICULUM VITAE XIN ZHANG, M.D., Ph.D. Office ... - Ochsner.org

CURRICULUM VITAEXIN ZHANG, M.D., Ph.D.Office AddressStaff Scientist Phone: (504) 842-2834Institution of Translational Research FAX: (504) 842-3381Tom & Gayle Benson Cancer Center, room 1N505Email: xzhang@ochsner.org1516 Jefferson HighwayNew Orleans, Louisiana 70121Education/Training• 1995 Beijing Medical University, China, Ph.D. in Immunology• 1990 Beijing Medical University, China, M.D.Fields of Specialization• I. Immunology• II. Molecular Biology• III. Rheumatology ResearchResearch Interests• Identification of human FDC-signaling molecules and T cell cytokines that stimulate germinalcenter B cell; characterization of FDC-signaling molecules that regulate B lymphomaprogression and their blocking agents.• Elucidating the role of follicular helper T cell (Tfh) on the survival and differentiation of autoreactiveB cells in the patients with Systemic Lupus Erythematosus (SLE) and Rheumatoid Arthritis.• Investigating the role of cancer-fostering microenvironment on cancer stem cell in therapyresistance and disease recurrence.Scientific Societies• 2011 Research Member of American College of Rheumatology• 2000 American Association of Immunologists• 1997 Chinese Immunological Society• 1995 Beijing Immunological SocietyProfessional Experience• 2012 Staff Scientist, Laboratory of Translational Cancer Research, Ochsner Clinic Foundation,New Orleans, LA• 2012 Director, Experimental Rheumatology Research, Ochsner Clinic Foundation

• 2009 Adjunct Assistant Professor, Louisiana State University Health Sciences Center, NewOrleans• 2008 Staff Scientist, Laboratory of Cellular Immunology, Ochsner Clinic Foundation, NewOrleans, LA• 1997 Postdoctoral fellow, Laboratory of Cellular Immunology, Alton Ochsner MedicalFoundation.• 1995 Assistant professor, Department of Immunology, Beijing Medical School, ChinaSelected Publications1. Zhang X, Lindwall E, Lyman J, Gauthier C, Spencer N, Alarakhia A, Webb-Detiege T, DongW, Zakem J, Davis W, and Quinet R. Ectopic CXCR5 + CD4 + Helper T Cells in SLE PatientsShare Phenotypic and Functional Properties with Germinal Center Follicular Helper T cells.Annals of Rheumatic Disease. 2012 (submitted)2. Shuh M, Zhang X, and Cohen AJ. Inhibitors of TNFa-TNFR1 Signaling: Potential ClinicalApplications in Ischemia/Reperfusion Injury. Biochemistry & Analytical Biochemistry. 2012 (accepted)3. Lee CG., Das B, Lin T, Grimes C, Zhang X, Lavezzi T, Huang L, Cole J, Yau L, and Li L. Arare fraction of drug-resistant follicular lymphoma initiating cells interact with folliculardendritic cells to maintain tumorigenic potential. British Journal of Haematology 158:79. 20124. Zhang X, Lyman J, Zakem J, Choi YS, and Quinet R. Increased frequency of curculatingCXCR5 + CD57 + CD4 + follicular T helper cells in patients with systemic lupus erythematosis. 9 thInternational Congress on System Lupus Erythematosis. Lupus, 19 (1):7. 20105. Yoon SO, Zhang X, Berner P, and Choi YS. IL-21 and IL-10 have redundant roles butdifferential capacities at different stages of plasma cell generation from human germinal centerB cells. J leukocyte biology. 86 (6): 1311-1318. 2009 (*equal author)6. Yoon SO, Zhang X, Berner P, Blom B, and Choi YS. Notch ligands expressed by folliculardendritic cells protect germinal center B cells from apoptosis. J Immunology. 183 (1): 352-358.2009. Zhang X, Park CS, Yoon SO, Li L, Hsu YM, Ambrose C, and Choi YS. BAFF supportshuman B cell differentiation in the lymphoid follicles through distinct receptors. InternationalImmunology, 17 (6): 779-788. 20057. Li L, Fu D, Zhang X, and Choi YS. Novel follicular dendritic cell molecule, 8D6, collaborateswith CD44 in supporting lymphomagenesis by a Burkitt lymphoma cell line, L3055.Blood.104:815-821. 20048. Jung J, Yi AK, Zhang X, Li L, and Choi YS. Distinct response of human B cell subpopulations inrecognition of an innate immune signal, CpG DNA. J Immunology, 169 (5): 2368-2373, 20029. Zhang X and Choi YS. A distinct role of a novel follicular dendritic cell-signaling molecule, 8D6,in germinal center B cell differentiation, Experimental Biology, FASEB, 2001

10. Zhang X, Li L, Jung J, Xiang S, and Choi YS. The distinct roles of T cell-derived cytokines and anovel follicular dendritic cell-signaling molecule 8D6 in germinal center-B cell differentiation. JImmunology, 167(1):49-56. 200111. Li Li*, Zhang X*, Kovcic S, Long AJ, Bourque K, Wood CR, and Choi YS. Identification of ahuman follicular dendritic cell molecule that stimulates germinal center B cell growth, J ofExperimental Medicine, 191(6):1077-1083. 2000 (* equal author)12. Choe J, Li L, Zhang X, Gregory CD, and Choi YS. Distinct role of follicular dendritic cells and Tcells in the proliferation, differentiation, and apoptosis of a centroblast cell line, L3055. JImmunology, 164(1):56-63. 200013. Zhang X, Xiang S, Yin Y, Wen Q, Wang L, and Chien YK. Effect of Lycium BarbarumPolysaccharide (LBP) on apoptosis of murine thymocyte. Chinese J. of Microbiology andImmunology, 17(3):204-207. 199714. Zhang X, Li J, Liang H, Wang L, and Chien YK, Effects of lycium Barbarum Polysaccharide oncell membrane fluidity and protein kinase C. J. of Beijing Medical University, 129(2):118-120.199715. Zhang X, Xiang S, Cui X, and Chien YK. Effect of Lycium Barbarum Polysaccharide onlymphocyte signal transduction system in mice. Chinese J. of Immunology, 13(5):289-291. 199716. Xiang S, Zhang X, Xu D, and Chien YK. Effects of lymphokines on CD23 expression on humantonsil B cell activated by PMA. Chinese J. of Immunology, 11(1):6-9. 199517. Zhang X, Zhao FS, Li ZY, Ma DL, and Chien YK. A new detection method of recombinanthuman interleukin 3 biological activity, Chinese J. of Hematology, 15(12):652-653, 199418. Xiang S, Zhang X, Xu D, and Chien YK, CD23 molecular expression on activated human tonsillymphocytes. Chinese J. of Microbiology and Immunology, 14(4):264-266. 199419. Du SY, Zhang X, Lou LM, and Chien YK. Effect of Lycium Barbarum (LB) on secretion of IL-6and TNF by human whole blood. Chinese J. of Immunology, 10(6):356 -358. 199420. Deng HY, Zhang X, Chang J, and Zou WZ. Assays and analysis of serum antinuclear antibody andglomerular Ig deposit in BXSB mice. Chinese J. of Dermatology, 25(1):6-7. 1992Abstract1. Ing S, Alarakhia A, Lindwall E, Lindwall E,Fraser A, Webb-Detiege T, Zakem J, Davis W,Choi YS, Quinet R, and Zhang X. Identification of Follicular Helper T Cells as a Novel CellPopulation Potentially Involved in the Pathogenesis of Rheumatoid Arthritis American Collegeof Rheumatology, Washington DC, 20122. Lindwall E, Fraser A, Alarakhia A, Ing S, Webb-Detiege T, Zakem J, Davis W, Choi YS,Quinet R, and Zhang X. Ectopic follicular Helper T cells support ongoing autoantibodyproduction in lupus patients. The 9th Ochsner Research Night. 20123. Alarakhia A, Ing S, Lindwall E, Fraser A, Webb-Detiege T, Zakem J, Davis W, Choi YS,

Quinet R, and Zhang X. Identification of Follicular Helper T Cells as a Novel CellPopulation Potentially Involved in the Pathogenesis of Rheumatoid Arthritis The 9thOchsner Research Night. 20124. Zhang X, Grimes C, Lin T, Das B, Huang L, Cole J and Li L. Follicular Lymphoma PatientCells Contain Cancer Stem Cells and Depend on Follicular Dendritic Cells for Proliferation andTumor Formation The 9th Ochsner Research Night. 20125. Zhang X, Grimes C, Spencer N, and Li L. Host bone marrow cells participate in tumor vesselformation that supports colon cancer cell growth. The 8th Ochsner Research Night. 20116. Gauthier C,Spencer N, Lyman J, Lindwall E, Alarakhia A, Menga G, Zakem J, Davis W, ChoiYS, Quinet R, and Zhang X. Molecular Mechanism of Increased T Follicular Helper Cells inPatients with Systemic Lupus Erythematosus. The 8th Ochsner Research Night. 20117. Lindwall E, Zhang X, Gauthier C, Lyman J, Alarakhia A, Zakem J, Davis W, Choi YS, QuinetR. Circulating T helper cells in patients with systemic lupus erythematosus share the phenotypicproperty with lymphoid T follicular helper cells. American College of Rheumatology, Chicago,20118. Yoon SO, Lee IY, Zhang X, Spencer N, Vo P, and Choi YS. Gamma secretase inhibitor,DAPT synergize with Vincristine in inhibiting B cell lymphoma formation. The 8th OchsnerResearch Night. 20119. Zhang X, Lyman J, Climentine R, Zakem J, Serebro L, Choi YS, and Quinet R. Increase ofCirculating CXCR5 + CD57 + CD4 + Follicular T helper Cells in Patients with Systemic LupusErythematosus. The 7th Ochsner Research Night. 201010. Lyman J, Zhang X, Zakem J, Davis W, Choi YS, Quinet R. Increased frequency of circulatingCXCR5 + CD57 + CD4 + follicular T helper cells in patients with systemic lupus erythematosus. 9 thInternational Congress on SLE, Vancouver, Canada, 201011. Zhang X, Vo P, Yoon SO, and Choi YS. Role of FDC derived Notch signal in the survival ofdrug resistant B lymphomas. The 7th Ochsner Research Night. 201012. Lee, IY., Zhang, X., Acock, M., Yoon, SO., and Li, L. Tumor Microenvironment Models usingEnhanced Green Fluorescent Protein (eGFP) Expressing Immunodeficient Mice. The 7thOchsner Research Night. 201013. Spencer N, Zhang X, Choi YS, and Yoon SO. Role of macrophages in human B lymphomaprogression. The 7th Ochsner Research Night. 201014. Zhao D, Acock M, Spencer N, Zhang X, Green H, Margolin D, Davis N, and Li L. LymphNode Stromal Cells Enhance Tumor Formation of Colon Cancer Stem Cells Isolated fromPatient Specimen. The 7th Ochsner Research Night. 201015. Zhang X, Dupre B, Clementine R, Zakem J, Davis W, Serebro L, Quinet R, and Choi YS.Abnormal BAFF expression on circulating T cells in Systemic Lupus Erythematosus. The 7thOchsner Research Night. 200916. Zhang X, Harris P, Quinet R, Dupre B, Zakem J, Davis W, Mallepalli J, Webb-Detiege T,

33. Li L, Zhang X, Kovacic S, Long AJ, Bourque K, Wood CR and Choi YS. Identification of ahuman follicular dendritic cell molecule that stimulates germinal center B cell growth. The 7 thWorkshop and Conference on Human Leucocyte Differentiation Antigens. Harrogate, UK, 200034. Li L, Zhang X, Kovacic S, Long AJ, Bourque K., Wood CR and Choi YS. A novel signalingmolecule of follicular dendritic cells for B cell differentiation. The 64 th Symposium: Signaling &Gene Expression in the Immune System. Cold Spring Harbor, New York, 1999