FIGO Proposal for Staging Cancer of the Ovary, Fallopian Tube and ...

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Notes• Involvement of retroperitoneal lymph nodes must beproven cytologically or histologically• Extension of tumour from omentum to spleen or liver(Stage IIIC) should be differentiated from isolatedparenchymal metastases (Stage IVB)
The five most common types of ovarian carcinomaHigh-gradeserousClear cell Endometrioid Mucinous Low-gradeserousUsual stage at diagnosisAdvanced Early Early EarlyEarly oradvancedPresumed tissue oforigin /precursor lesionFallopian tube ortubal metaplasiain inclusions ofOSEEndometriosis,adenofibromaEndometriosis,adenofibromaAdenoma–borderline –carcinomasequence;teratomaSerousborderlinetumorGenetic riskBRCA1/2 ? HNPCC ? ?Significant molecularabnormalitiesp53 and pRbpathwayHNF-1βARID1APTEN, β-Catenin, K-rasMI, ARID1AK-rasBRAF orK-rasProliferationHigh Low Low Intermediate LowResponse to primarychemotherapyPrognosis80% 15% ? 15% 26-28%Poor Intermediate Favorable Favorable Favorable
Page 1: FIGO Proposal for StagingCancer of
Page 13 and 14: Clinical Staging of Cancer of theOv
Page 15 and 16: Histologic Subtypes of OvarianCarci
Page 17 and 18: HGCLGSCMCECCCC
Page 19 and 20: Endometrioid and Clear Cell Tumors
Page 21 and 22: Clear cell carcinoma
Page 23 and 24: ITumor confined to ovaries or fallo
Page 25: IITumor involves one or both ovarie
Page 28 and 29: New Stage III - FIGO 2012IIIOne or
Page 30 and 31: SBT in Lymph Nodes (30%)LN: Mulleri
Page 32 and 33: SBT in lymph node (fibrosis)
Page 37 and 38: Ovarian Carcinomas involving Lymph
Page 39 and 40: Stage IIIIII Tumor involves one or
Page 41 and 42: IVDistant metastasis excluding peri
Page 43: Notes• The primary site i.e: ovar
Page 47: Thank youfor yourattention

FIGO Proposal for Staging Cancer of the Ovary, Fallopian Tube and ...

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