10th International Magnesium Symposium Schedule of Events

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Intracellular magnesium in furosemide treated patients with congestive heart
failure suffering from diabetes mellitus and/or renal dysfunction
I. Alon, D. Almoznino-Sarafian, S. Berman, O. Gorelik, M. Shteinshnaider, D.Modai,
N. Cohen, Department Of Internal Medicine "F" And Nephrology Division, Assaf
Harofeh Medical Center, Zerifin, Beer Yaakov, Israel. Internal6@Asaf.Health.Gov.Il
Hypomagnesemia and especially intracellular Mg depletion are frequent in
congestive heart failure (CHF). In many such patients furosemide treatment and
comorbidity with diabetes mellitus (DM) and/or renal dysfunction (RD) are common.
DM and furosemide may aggravate hypomagnesemia, while renal dysfunction may
cause hypermagnesemia. Since normal serum Mg concentration may coexist with
intracellular Mg aberrations, we studied peripheral blood mononuclear cell Mg
content in four relevant normomagnesemic patient subgroups. Patients: Included
were 71 (33 males, 39 females, age 72.3±9.7 years) furosemide treated patients with
symptomatic CHF, classified as follows: A. 12 patients without DM or RD; B. 21 with
DM; C. 14 with RD; D. 24 with DM and RD.
RESULTS: Whole group Intracellular Mg content was 1.66±0.29 mg/mg cell protein.
Individual values in the 4 subgroups A; B; C and D were 1.69±0.37; 1.81±0.26;
1.59±0.29; 1.57±0.22 respectively. When compared with DM subgroup, respective Pvalues
for subgroups RD, RD+DM and no DM/RD were 0.04, 0.002 and 0.6 (N.S).
Thus, only RD is associated with a significantly lower Mg content, and overrides the
tendency, albeit not reaching statistical significance, of DM for elevated values.
CONCLUSIONS: Within a group of normomagnesemic furosemide treated CHF
patients, intracellular Mg content differed in various subgroups in parallel with
comorbidities. RD as opposed to DM is associated with lower Mg content.
Assessment of intracellular Mg in relevant patient subgroups is essential for
evaluation of risks and preventive measures.