Mikroba Penghasil Antibiotik
Antibiotik 01
Antibiotik 01
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Biosintesis penisilin:<br />
Penicillium chrysogenum<br />
HOOC-CH-CH 2 -CH 2 -CH 2 -COOH<br />
NH 2<br />
L-α-Asam Aminoadipat (L-α-AAA)<br />
Cys<br />
Val<br />
L-α-AAA-Cys<br />
L-α-Aminoadippyl-Cysteinil-D-Valine<br />
H<br />
L-α-AAA–N<br />
S<br />
Siklisasi 2 tahap<br />
H<br />
-CH 2 -CO–N<br />
S<br />
L-α-AAA-CoA-SH<br />
O<br />
N<br />
COOH<br />
Isopenilisin N<br />
fenilasetat<br />
O<br />
N<br />
COOH<br />
Benzil-penisilin<br />
Penisilin transakilase
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