A Review of immunomodulators with reference to Canova - Similima
A Review of immunomodulators with reference to Canova - Similima
A Review of immunomodulators with reference to Canova - Similima
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Cy<strong>to</strong>kines are diverse family <strong>of</strong> polypeptide hormone & growth<br />
fac<strong>to</strong>r that regulate many cellular processes produced by<br />
variety <strong>of</strong> immune cells <strong>to</strong> communicate & orchestrate an<br />
immune attack<br />
Modulation <strong>of</strong> cy<strong>to</strong>kine secretion may <strong>of</strong>fer novel approaches<br />
in treatment <strong>of</strong> various diseases<br />
Done by implementation <strong>of</strong> antiinflamma<strong>to</strong>ry cy<strong>to</strong>kines<br />
(IF,IL 4,GF) / neutralizing proinflamma<strong>to</strong>ry cy<strong>to</strong>kines ( IL 2, IF<br />
gamma, TNF)<br />
IL - Used in treatment <strong>of</strong> RA ( Prevents interaction <strong>of</strong> IL1 <strong>to</strong> its<br />
cell surface recep<strong>to</strong>rs)<br />
TNF – RA, Crohn’s disease, Psoriasis ( AI )<br />
INF alpha – advanced melanoma<br />
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