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A Review of immunomodulators with reference to Canova - Similima

A Review of immunomodulators with reference to Canova - Similima

A Review of immunomodulators with reference to Canova - Similima

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In sarcoma - <strong>Canova</strong> treated mice showed delay in<br />

development & reduction in size <strong>of</strong> the tumor, increased<br />

infiltration <strong>of</strong> lymphoid cells, GT & fibrosis sorrounding the<br />

tumor, Leucocy<strong>to</strong>sis & Lymphocy<strong>to</strong>sis ( enhanced immune<br />

response) compared <strong>to</strong> control group<br />

Macrophages showed 86% activation in <strong>Canova</strong> treated & 15%<br />

activation in control<br />

TNF alpha production was decreased while IL2 & IFN gamma<br />

revealed no difference <strong>with</strong> control group<br />

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