Treatment Alternatives in Charcot Arthropathy of the Foot
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Pediatric Bra<strong>in</strong><br />
Tumor Surgery<br />
Although pediatric neurosurgeons assess and<br />
treat a wider variety <strong>of</strong> conditions than <strong>the</strong>ir<br />
colleagues who treat adult patients, specialized<br />
centers for pediatric tumors and sp<strong>in</strong>e conditions<br />
<strong>of</strong>fer specific programs for some patients.<br />
Eric Thompson, MD, a Duke pediatric neurosurgeon<br />
and tumor specialist, leads <strong>the</strong> Duke<br />
University Medical Center multidiscipl<strong>in</strong>ary<br />
pediatric bra<strong>in</strong> tumor board composed <strong>of</strong><br />
neurosurgeons, neuro-oncologists, radiation<br />
oncologists, neuroradiologists, neuropathologists,<br />
and tra<strong>in</strong>ees from those fields. The board<br />
discusses cases and reaches a consensus on treatment<br />
plans for <strong>the</strong> most challeng<strong>in</strong>g tumor cases.<br />
The most common types <strong>of</strong> tumors treated <strong>in</strong><br />
children are those <strong>in</strong> <strong>the</strong> posterior fossa, <strong>in</strong>clud<strong>in</strong>g<br />
gliomas, medulloblastomas, and ependymomas.<br />
Metastases, although fairly rare, occur <strong>in</strong> up to 5%<br />
<strong>of</strong> children with solid tumors.<br />
Larger centers <strong>of</strong>ten <strong>of</strong>fer <strong>the</strong> advantage <strong>of</strong><br />
cutt<strong>in</strong>g-edge technology as well as cl<strong>in</strong>ical expertise.<br />
Intraoperative magnetic resonance imag<strong>in</strong>g<br />
(MRI) is frequently used at Duke to facilitate <strong>the</strong><br />
maximal safe removal <strong>of</strong> bra<strong>in</strong> tumors. Ano<strong>the</strong>r<br />
significant advantage is <strong>the</strong> ability to enroll<br />
children <strong>in</strong> cl<strong>in</strong>ical trials, especially patients whose<br />
cancer has progressed. Duke is a member <strong>of</strong> both<br />
<strong>the</strong> Pediatric Bra<strong>in</strong> Tumor Consortium and <strong>the</strong><br />
Children’s Oncology Group.<br />
When to Refer<br />
Parents most commonly ask pediatric neurosurgeons<br />
<strong>the</strong> follow<strong>in</strong>g 2 questions:<br />
• Is <strong>the</strong> child’s head an abnormal shape?<br />
• Is <strong>the</strong> child’s head too large?<br />
The answers to <strong>the</strong>se questions suggest when<br />
referral to specialists might be prudent. If a child’s<br />
head is flat <strong>in</strong> <strong>the</strong> back and <strong>the</strong> head is clearly not<br />
gett<strong>in</strong>g rounder after several months <strong>of</strong> prohibit<strong>in</strong>g<br />
<strong>the</strong> child from lay<strong>in</strong>g on his or her back, <strong>the</strong>n<br />
it is time to refer to a pediatric neurosurgeon.<br />
Regard<strong>in</strong>g head size, <strong>the</strong>re is usually not cause for<br />
alarm unless <strong>the</strong> head has begun to grow at an<br />
accelerated rate. “If a child’s skull size is cross<strong>in</strong>g<br />
multiple percentiles, that would be a good time to<br />
refer,” Thompson says.<br />
Duke welcomes <strong>the</strong> opportunity to work closely with<br />
community physicians to treat pediatric patients with<br />
bra<strong>in</strong> and sp<strong>in</strong>e tumors, craniosynostosis, vascular<br />
disease, epilepsy, sp<strong>in</strong>a bifida, hydrocephalus, and<br />
spasticity. To learn more or to refer, call 844-790-2013.<br />
(T2-weighted MRI reveals a medulloblastoma.)<br />
6 Cl<strong>in</strong>ical Practice Today from Duke Medic<strong>in</strong>e