PROGRAM BOOK
ORS-2016-PROGRAM-BOOK_FOR_WEB
ORS-2016-PROGRAM-BOOK_FOR_WEB
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TUESDAY | SESSIONS 10:30 AM – 11:30 AM | TUESDAY, MARCH 8, 2016<br />
TIME<br />
SPOTLIGHT SESSION 57<br />
Mechanobiology and the<br />
Science of Engineering In<br />
Vivo Conditions<br />
SESSION 58<br />
Implant Fixation<br />
and Tribocorrosion<br />
SESSION 59<br />
Skeletal Development/<br />
Remodeling Health<br />
and Disease<br />
SESSION 60<br />
Cancer, Tumors:<br />
Osteosarcoma<br />
SESSION 61<br />
Meniscus Tissue<br />
Engineering<br />
ROOM<br />
Coronado H-J<br />
Coronado K<br />
Coronado L<br />
Fiesta 5<br />
Fiesta 6<br />
Moderators<br />
Rhima Coleman, PhD and<br />
Robert Sah, MD, PhD<br />
Bo Gao, PhD and<br />
Michael Morlock, PhD<br />
Thomas Hering, PhD and<br />
Audrey McAlinden, PhD<br />
Timothy Damron, MD and<br />
Michelle A. Ghert, MD<br />
Catherine Holt, PhD and<br />
Aaron Stoker, PhD<br />
10:30 AM<br />
10:40 AM<br />
SPOTLIGHT SPEAKER<br />
Clark T. Hung, PhD<br />
Chrondrocyte<br />
Mechanobiology:<br />
Application to Cartilage<br />
Tissue Engineering<br />
Paper No. 0372<br />
Intermittent Parathyroid Hormone<br />
Enhances Osseointegration of<br />
a Physiologically Loaded Tibial<br />
Implant in Ovariectomized Mice<br />
Xu Yang, Joseph E. Koressel,<br />
Matthew B. Shirley, Caroline Brial,<br />
Arvinth Sethuraman, Christina Asare,<br />
Vinicius Craveiro, Jodhvir Mangat,<br />
Aleksey Dvorzhinskiy, Benjamin F.<br />
Ricciardi, F. Patrick Ross, Marjolein C.H.<br />
Van der Meulen, Mathias P.G. Bostrom<br />
Paper No. 0373<br />
Locally Administered Bisphosphonate<br />
in Acetabular Revisions<br />
Using the Bone Impaction<br />
Technique — a Randomized,<br />
Placebo-Controlled Study<br />
Evaluated with Radiostereometric<br />
Analysis and Dual-Energy<br />
X-ray Absorptiometry<br />
Magnus Tägil, Gunnar Flivik,<br />
Vasilis Zampelis, Martin Sundberg,<br />
Ola Belfrage<br />
Paper No. 0378<br />
The Majority of Fibrodysplasia<br />
Ossificans Progressiva-Related<br />
Variants of Acvr1 Drive Heterotopic<br />
Ossification by Aberrantly<br />
Perceiving the Natural Antagonist<br />
Activin A as an Agonist<br />
Dana M. Alessi Wolken, Hyon J. Kim,<br />
Joyce McClain, Richard A. Corpina,<br />
Harikiran Nistala, Christopher J.<br />
Schoenherr, Andrew J. Murphy,<br />
Sarah J. Hatsell, Aris N. Economides,<br />
Vincent Idone<br />
Paper No. 0379<br />
Adamts 18, A Novel Regulator<br />
of Skeletal Maturity and<br />
Bone Remodeling<br />
Sardar Uddin, Chuanju Liu<br />
Paper No. 0384<br />
Opportunities for Drug<br />
Repurposing in Osteosarcoma:<br />
A Screen of FDA‐Approved<br />
Oncology Drugs in a<br />
Micrometastatic Model of Disease<br />
Christopher D. Collier,<br />
James D. Buschbach, Deep A .Gandhi,<br />
Patrick J. Getty, Edward M. Greenfield<br />
Paper No. 0385<br />
Targeted Inhibition of<br />
Insulin-Like Growth Factor 1<br />
Receptor Signaling for<br />
Potential Treatment of<br />
Human Osteosarcoma<br />
Maryam K. Mohammed,<br />
Zhan Liao, Hue H Luu, Rex C. Haydon,<br />
Tong-Chuan He<br />
Paper No. 0390<br />
Evaluating Mechanical<br />
Properties of a Decellularized<br />
and Laser-Drilled<br />
Meniscus Replacement<br />
Emily H. Lakes, Peter S. McFetridge,<br />
Kyle D. Allen<br />
Paper No. 0391<br />
Development of a Novel<br />
Decellularized Meniscal Scaffold<br />
for Use in Tissue Engineering<br />
Farrah A. Monibi, Aaron M. Stoker,<br />
Ferris M. Pfeiffer, Keiichi Kuroki,<br />
Seth L. Sherman, James L. Cook<br />
10:50 AM<br />
Paper No. 0374<br />
Low BMD and Long Time in<br />
Service Increase Total Knee<br />
Replacement Failure Risk from<br />
Mechanical Overload<br />
Mark A. Miller, William Zimmerman,<br />
Kenneth A. Mann<br />
Paper No. 0380<br />
Intracellular Cholesterol Production<br />
Is Required for Chondrocyte<br />
Differentiation: Analysis of Srebp<br />
Cleavage-Activating Protein (scap)<br />
Deficient Mice<br />
Hidetoshi Tsushima, Shu-Hsuan C Hsu,<br />
Yuning J. Tang, Terese Camp,<br />
Puvi Nadesan, Vijitha Puviindran,<br />
Yinshi Ren, Anthony J. Mirando,<br />
Deepika Sharma, Matthew J. Hilton,<br />
Benjamin Alman<br />
Paper No. 0386<br />
Three-Dimensional Drug-<br />
Screening Platform for<br />
Progression of Osteosarcoma<br />
Micrometastases Demonstrates<br />
Heterogeneous Response to<br />
MAP Chemotherapy<br />
Christopher D. Collier, Emily C. Wirtz,<br />
William Z. Morris, Patrick J. Getty,<br />
Edward M. Greenfield<br />
Paper No. 0392<br />
Heterogeneous Tissue-<br />
Engineered Constructs (hetTECs)<br />
Recapitulate the Micromechanical<br />
and Mechanobiologic<br />
Complexity of Native Dense<br />
Connective Tissues<br />
Su-Jin Heo, Woojin M. Han,<br />
Claire M. McLeod, Randall L. Duncan,<br />
Dawn M. Elliott, Robert L. Mauck<br />
11:00 AM<br />
Paper No. 0369<br />
N-Cadherin Presentation Alters<br />
Rac1 Signaling to Modulate<br />
Mesenchymal Progenitor Cell<br />
Mechanosensing of Soft Tissue<br />
Microenvironments<br />
Brian D. Cosgrove, Keeley L. Mui,<br />
Tristan P. Driscoll, Richard K. Assoian,<br />
Jason A. Burdick, Robert L. Mauck<br />
Paper No. 0375<br />
Clinical Relevance of Corrosion<br />
Patterns Attributed to<br />
Inflammatory Cell Induced<br />
Corrosion: A Retrieval Study<br />
Anna Di Laura, Harry Hothi,<br />
Jay Meswania, Robert Whittaker,<br />
Danielle De Villiers, Gordon Blunn,<br />
John Skinner, Alister Hart<br />
Paper No. 0381<br />
Radical Therapeutic Strategy<br />
for Foramen Magnum Stenosis<br />
and Spinal Canal Stenosis in<br />
Achondroplasia<br />
Masaki Matsushita, Hiroshi Kitoh,<br />
Kenichi Mishima, Hiroshi Sugiura,<br />
Sachi Hasegawa, Naoki Ishiguro,<br />
Kinji Ohno<br />
Paper No. 0387<br />
Intra-Tumoral Heterogeneity<br />
in Osteosarcoma and Its<br />
Therapeutic Implications<br />
Padraic P. Levings,<br />
Emma V. Hyddmark, Elham Nasri,<br />
Ali Zarezadeh, Steven Ghivizzzani,<br />
Parker Gibbs<br />
Paper No. 0393<br />
Transplantation of Aggregates of<br />
Synovial Mesenchymal Stem Cells<br />
Promotes Meniscus Regeneration<br />
in Monkeys<br />
Shimpei Kondo, Takeshi Muneta,<br />
Yusuke Nakagawa, Toshifumi<br />
Watanabe, Kunikazu Tsuji,<br />
Ichiro Sekiya<br />
TUESDAY<br />
11:10 AM<br />
Paper No. 0370<br />
A Secretomic Comparison of the<br />
Induction of Chondrogenesis in<br />
Human Mesenchymal Stem Cells<br />
via TGF-β1 and Mechanical Load<br />
Oliver F.W. Gardner, Niamh Fahy,<br />
Mauro Alini, Martin Stoddart<br />
Paper No. 0376<br />
Effect of Biofilm on<br />
CoCrMo Corrosion<br />
Philip Chuang, Viswanathan<br />
Swaminathan, Leonid Pavlovsky,<br />
Ligaya Marquez-Catral,<br />
David Jones, Lin Song<br />
Paper No. 0382<br />
Primary Cilia Are Required for<br />
Migration and Differentiation of<br />
Periosteal Progenitors in Skeletal<br />
Development<br />
Emily Moore, Yuchen Yang,<br />
Christopher Jacobs<br />
Paper No. 0388<br />
Wnt/β-catenin Signaling Is<br />
Activated in Chondrosarcoma<br />
and May Serve as a Potential<br />
Target for Treatment<br />
Zhiyong He, David Geller, Daniel<br />
Leong, Justin Tang, Johnathan Morris,<br />
Shalom Kalnicki, Chandan Guha,<br />
Hui Bin Sun<br />
Paper No. 0394<br />
Co-Culture of Meniscal<br />
Fibrochondrocytes and<br />
Mesenchymal Stem Cells Enhances<br />
the Lubrication of Tissue-<br />
Engineered Constructs Through<br />
Lubricin Localization<br />
Edward D. Bonnevie,<br />
Mary Clare McCorry,<br />
Lawrence J. Bonassar<br />
58<br />
11:20 AM<br />
Paper No. 0371<br />
Il-1α Enhances Piezo1-Mediated<br />
Mechanotransduction in<br />
Articular Chondrocytes<br />
Whasil Lee, Holly A. Leddy,<br />
Amy McNulty, Farshid Guilak,<br />
Wolfgang Liedtke<br />
Paper No. 0377<br />
Retrieval Analysis of<br />
Degradation in Modular<br />
Total Knee Replacements<br />
Audrey Martin, Kirsten Seagers,<br />
Michael Mayor, Douglas Van Citters<br />
Paper No. 0383<br />
TIMP3 Gene Affects<br />
Compositional, Structural and<br />
Mechanical Integrity of Bone<br />
Brendyn Miller, Lyudmila Spevak,<br />
Lyudmila Lukashova, Behzad<br />
Javaheri, Andrew A. Pitsillides,<br />
George Bou-Gharios, Adele L. Boskey,<br />
Alessandra Carriero<br />
Paper No. 0389<br />
Tumor-Elicited Secretion of IL6<br />
and of IL8 from Reactive<br />
Mesenchymal Stroma Is<br />
Enhanced Under the Acidic<br />
Microenvironment of Glycolytic<br />
Cancer Cells and Promotes<br />
Osteosarcoma Stemness<br />
Sofia Avnet, Gemma Di Pompo,<br />
Margherita Cortini, Gloria Bonuccelli,<br />
Tokuhiro Chano, Nicola Baldini<br />
Paper No. 0395<br />
A New Silk Fibroin Scaffold for<br />
Partial Meniscal Replacement<br />
Exhibits Friction Coefficients<br />
Similar to the Physiologically<br />
Articulating Surfaces<br />
Daniela Warnecke, Natalie B. Schild,<br />
Svenja Klose, Nick Skaer, Oliver Kessler,<br />
Anita Ignatius, Lutz Dürselen
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