Best of AACR Journals

The Best of the AACR Journals
The AACR is proud to present “The Best of the AACR Journals,” a collection of the most-cited articles published in 2013 across the
AACR journal portfolio. We congratulate the authors of these outstanding articles for their tireless efforts and contributions to the
cancer research field.
Each journal’s section in the collection includes the most-cited review article and the four most-cited research articles based on the
total number of citations from date of publication through January 2015.
Table of Contents
Cancer Discovery
The Basic Principles of Chimeric Antigen Receptor Design
Michel Sadelain, Renier Brentjens, and Isabelle Rivière .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .1
Activating HER2 Mutations in HER2 Gene Amplification Negative Breast Cancer
Ron Bose, Shyam M. Kavuri, Adam C. Searleman, Wei Shen, Dong Shen, Daniel C. Koboldt, John Monsey, Nicholas Goel,
Adam B. Aronson, Shunqiang Li, Cynthia X. Ma, Li Ding, Elaine R. Mardis, and Matthew J. Ellis .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .2
First-in-Humans Trial of an RNA Interference Therapeutic Targeting VEGF
and KSP in Cancer Patients with Liver Involvement
Josep Tabernero, Geoffrey I. Shapiro, Patricia M. LoRusso, Andres Cervantes, Gary K. Schwartz, Glen J. Weiss, Luis Paz-Ares,
Daniel C. Cho, Jeffrey R. Infante, Maria Alsina, Mrinal M. Gounder, Rick Falzone, Jamie Harrop, Amy C. Seila White,
Iva Toudjarska, David Bumcrot, Rachel E. Meyers, Gregory Hinkle, Nenad Svrzikapa, Renta M. Hutabarat, Valerie A. Clausen,
Jeffrey Cehelsky, Saraswathy V. Nochur, Christina Gamba-Vitalo, Akshay K. Vaishnaw, Dinah W.Y. Sah, Jared A. Gollob,
and Howard A. Burris III .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .2
Amplification of the MET Receptor Drives Resistance to Anti-EGFR Therapies in Colorectal Cancer
Alberto Bardelli, Simona Corso, Andrea Bertotti, Sebastijan Hobor, Emanuele Valtorta, Giulia Siravegna,
Andrea Sartore-Bianchi, Elisa Scala, Andrea Cassingena, Davide Zecchin, Maria Apicella, Giorgia Migliardi,
Francesco Galimi, Calogero Lauricella, Carlo Zanon, Timothy Perera, Silvio Veronese, Giorgio Corti,
Alessio Amatu, Marcello Gambacorta, Luis A. Diaz Jr, Mark Sausen, Victor E. Velculescu, Paolo Comoglio,
Livio Trusolino, Federica Di Nicolantonio, Silvia Giordano, and Salvatore Siena .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .3
Identification of Targetable FGFR Gene Fusions in Diverse Cancers
Yi-Mi Wu, Fengyun Su, Shanker Kalyana-Sundaram, Nickolay Khazanov, Bushra Ateeq, Xuhong Cao, Robert J. Lonigro, Pankaj Vats,
Rui Wang, Su-Fang Lin, Ann-Joy Cheng, Lakshmi P. Kunju, Javed Siddiqui, Scott A. Tomlins, Peter Wyngaard, Seth Sadis,
Sameek Roychowdhury, Maha H. Hussain, Felix Y. Feng, Mark M. Zalupski, Moshe Talpaz, Kenneth J. Pienta, Daniel R. Rhodes,
Dan R. Robinson, and Arul M. Chinnaiyan .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .3
Cancer Epidemiology, Biomarkers & Prevention
Oral Contraceptive Use and Risk of Breast, Cervical, Colorectal, and Endometrial Cancers: A Systematic Review
Jennifer M. Gierisch, Remy R. Coeytaux, Rachel Peragallo Urrutia, Laura J. Havrilesky, Patricia G. Moorman,
William J. Lowery, Michaela Dinan, Amanda J. McBroom, Vic Hasselblad, Gillian D. Sanders, and Evan R. Myers . .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .4
Cancer Survivors in the United States: Prevalence across the Survivorship
Trajectory and Implications for Care
Janet S. de Moor, Angela B. Mariotto, Carla Parry, Catherine M. Alfano, Lynne Padgett, Erin E. Kent, Laura Forsythe,
Steve Scoppa, Mark Hachey, and Julia H. Rowland .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .5
Vegetarian Diets and the Incidence of Cancer in a Low-risk Population
Yessenia Tantamango-Bartley, Karen Jaceldo-Siegl, Jing Fan, and Gary Fraser . .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .5
Genetic Susceptibility Loci for Subtypes of Breast Cancer in an African American Population
Julie R. Palmer, Edward A. Ruiz-Narvaez, Charles N. Rotimi, L. Adrienne Cupples, Yvette C. Cozier,
Lucile L. Adams-Campbell, and Lynn Rosenberg .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .6
Drinking Water Arsenic in Northern Chile: High Cancer Risks 40 Years after Exposure Cessation
Craig M. Steinmaus, Catterina Ferreccio, Johanna Acevedo Romo, Yan Yuan, Sandra Cortes, Guillermo Marshall,
Lee E. Moore, John R. Balmes, Jane Liaw, Todd Golden, and Allan H. Smith .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .6
Cancer Immunology Research
Getting Personal with Neoantigen-Based Therapeutic Cancer Vaccines
Nir Hacohen, Edward F. Fritsch, Todd A. Carter, Eric S. Lander, and Catherine J. Wu .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .7
Anti-CTLA-4 Antibodies of IgG2a Isotype Enhance Antitumor Activity through Reduction
of Intratumoral Regulatory T Cells
Mark J. Selby, John J. Engelhardt, Michael Quigley, Karla A. Henning, Timothy Chen, Mohan Srinivasan, and Alan J. Korman .. .. .. .. .. .. .. .. .. .. .8
The Best of the AACR Journals
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