Best of AACR Journals

Table of Contents
Analysis of Tumor Specimens at the Time of Acquired Resistance to EGFR-TKI Therapy
in 155 Patients with EGFR-Mutant Lung Cancers
Helena A. Yu, Maria E. Arcila, Natasha Rekhtman, Camelia S. Sima, Maureen F. Zakowski, William Pao,
Mark G. Kris, Vincent A. Miller, Marc Ladanyi, and Gregory J. Riely .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. ..17
Durable Cancer Regression Off-Treatment and Effective Reinduction Therapy with an Anti-PD-1 Antibody
Evan J. Lipson, William H. Sharfman, Charles G. Drake, Ira Wollner, Janis M. Taube, Robert A. Anders, Haiying Xu,
Sheng Yao, Alice Pons, Lieping Chen, Drew M. Pardoll, Julie R. Brahmer, and Suzanne L. Topalian .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. ..18
An Epithelial–Mesenchymal Transition Gene Signature Predicts Resistance to EGFR and PI3K
Inhibitors and Identifies Axl as a Therapeutic Target for Overcoming EGFR Inhibitor Resistance
Lauren Averett Byers, Lixia Diao, Jing Wang, Pierre Saintigny, Luc Girard, Michael Peyton, Li Shen, Youhong Fan, Uma Giri, Praveen
K. Tumula, Monique B. Nilsson, Jayanthi Gudikote, Hai Tran, Robert J.G. Cardnell, David J. Bearss, Steven L. Warner, Jason M. Foulks,
Steven B. Kanner, Varsha Gandhi, Nancy Krett, Steven T. Rosen, Edward S. Kim, Roy S. Herbst, George R. Blumenschein, J. Jack Lee, Scott
M. Lippman, K. Kian Ang, Gordon B. Mills, Waun K. Hong, John N. Weinstein, Ignacio I. Wistuba, Kevin R. Coombes, John D. Minna,
and John V. Heymach .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. ..18
Molecular Cancer Research
Radiation Survivors: Understanding and Exploiting the Phenotype following Fractionated Radiation Therapy
Adeola Y. Makinde, Molykutty John-Aryankalayil, Sanjeewani T. Palayoor, David Cerna, and C. Norman Coleman .. .. .. .. .. .. .. .. .. .. .. .. .. .. ..19
A Modified HSP70 Inhibitor Shows Broad Activity as an Anticancer Agent
Gregor M. Balaburski, Julia I.-Ju Leu, Neil Beeharry, Seth Hayik, Mark D. Andrake, Gao Zhang, Meenhard Herlyn,
Jessie Villanueva, Roland L. Dunbrack, Tim Yen, Donna L. George, and Maureen E. Murphy .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. ..20
The Heterochronic microRNA let-7 Inhibits Cell Motility by Regulating the Genes in the
Actin Cytoskeleton Pathway in Breast Cancer
Xiaowen Hu, Jinyi Guo, Lan Zheng, Chunsheng Li, Tim M. Zheng, Janos L. Tanyi, Shun Liang, Chiara Benedetto,
Marco Mitidieri, Dionyssios Katsaros, Xia Zhao, Youcheng Zhang, Qihong Huang, and Lin Zhang .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. ..20
Procollagen Lysyl Hydroxylase 2 Is Essential for Hypoxia-Induced Breast Cancer Metastasis
Daniele M. Gilkes, Saumendra Bajpai, Carmen C. Wong, Pallavi Chaturvedi, Maimon E. Hubbi, Denis Wirtz,
and Gregg L. Semenza .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. ..21
Activation of the FGF2-FGFR1 Autocrine Pathway: A Novel Mechanism of Acquired Resistance to Gefitinib in NSCLC
Hideki Terai, Kenzo Soejima, Hiroyuki Yasuda, Sohei Nakayama, Junko Hamamoto, Daisuke Arai, Kota Ishioka,
Keiko Ohgino, Shinnosuke Ikemura, Takashi Sato, Satoshi Yoda, Ryosuke Satomi, Katsuhiko Naoki, and Tomoko Betsuyaku . .. .. .. .. .. .. .. .. .. ..21
Molecular Cancer Therapeutics
FOX(M1) News—It Is Cancer
Marianna Halasi and Andrei L. Gartel . .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. ..22
Genome and Transcriptome Sequencing in Prospective Metastatic Triple-Negative
Breast Cancer Uncovers Therapeutic Vulnerabilities
David W. Craig, Joyce A. O’Shaughnessy, Jeffrey A. Kiefer, Jessica Aldrich, Shripad Sinari, Tracy M. Moses,
Shukmei Wong, Jennifer Dinh, Alexis Christoforides, Joanne L. Blum, Cristi L. Aitelli, Cynthia R. Osborne,
Tyler Izatt, Ahmet Kurdoglu, Angela Baker, Julie Koeman, Catalin Barbacioru, Onur Sakarya,
Francisco M. De La Vega, Asim Siddiqui, Linh Hoang, Paul R. Billings, Bodour Salhia, Anthony W. Tolcher,
Jeffrey M. Trent, Spyro Mousses, Daniel Von Hoff, and John D. Carpten .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. ..23
EGFR Exon 20 Insertion Mutations in Lung Adenocarcinomas: Prevalence,
Molecular Heterogeneity, and Clinicopathologic Characteristics
Maria E. Arcila, Khedoudja Nafa, Jamie E. Chaft, Natasha Rekhtman, Christopher Lau,
Boris A. Reva, Maureen F. Zakowski, Mark G. Kris, and Marc Ladanyi . .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. ..23
NF-kB2/p52 Induces Resistance to Enzalutamide in Prostate Cancer:
Role of Androgen Receptor and Its Variants
Nagalakshmi Nadiminty, Ramakumar Tummala, Chengfei Liu, Joy Yang, Wei Lou,
Christopher P. Evans, and Allen C. Gao .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. ..24
Inhibition of Mutant GNAQ Signaling in Uveal Melanoma Induces
AMPK-Dependent Autophagic Cell Death
Grazia Ambrosini, Elgilda Musi, Alan L. Ho, Elisa de Stanchina, and Gary K. Schwartz .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. ..24
The Best of the AACR Journals
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