Tumor – see the opportunity

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Tumor cells lose their ability to communicate. 4 BIESTMILCH Tumor – see the opportunity
A GENETIC DEFECT ALONE DOES NOT NECESSARILY LEAD TO A TUMOR DEVELOPING It can take decades for a tumor to reach a size of medical significance, i.e. until disorders become evident. Tumors usually grow very slowly and, in addition to that, a series of unfortunate circumstances must concur. A defect in the DNA is not sufficient to make a tumor develop and that is why a tumor is not simply a collection of malicious cells whose growth proceeds in an aggressive and uncontrolled way. And because of this fact, a suitable lifestyle can very much prevent the development of a tumor. Thus, for a tumor to start growing, a number of factors must concur. - There are disorders of the cell biology on the level of the cell core, the cytoplasm, the receptors, the extra-cellular matrix and the neighboring cells. The underlying processes are arranged on a time basis in 3 phases: 1) the initiation of the DNA, 2) the promotion in the intra- and extra-cellular environment and 3) the progression through tumor-specific communication processes beyond the primary tumor. First of all, the cell experiences a genetic change, it is initiated. It can linger or pause in this state for centuries on end. This means a tumor never grows. So, as you see, a genetic defect does not suffice to produce a tumor. However, if such a cell experiences an irritation such as the influence of a carcinogen or a chronic inflammatory change to its environment, then the genetic defect manifests in the development of a tumor. A chronic inflammatory environment gives this genetically weak cell a growth advantage over other cells. THE TUMOR CELL GROWS INDEPENDENTLY No cell can multiply itself without the stimulating signals. In contrast, a tumor cell grows independently; it loses its coupling to the environment. Many oncogenes function by copying normal growth signals. The bridging molecules (connexins) are molecules that are essential for the communication between cells. Stem cells are characterized by not carrying such connexins on their surface. Thus, they have no bridges for communicating with other cells. These bridging molecules are significantly involved in controlling the growth of cells and tissues. Communication is thus an important control process. A characteristic cancer cell: 1) Self-sufficiency of growth signals 2) Insensitive towards the growth of repressive signals 3) Infiltration of cell termination (apoptosis) 4) Endless potential for proliferation 5) Maintaining the formation of vessels 6) Penetration into the tissue and metastasis THE CELL‘S ENVIRONMENT IS JUST AS IMPORTANT AS THE CELL ITSELF In science, one speaks of epigenetic processes, which play a central role in the development of tumors. As you know, the cell comprises one cell nucleus in which chromosomes, the DNA, the genetic material so to say are located. Cytoplasm, in which a large number of accumulations of molecules form structures that are necessary for the cell to live and to become what it is and what it does, surrounds this cell nucleus. The cell as a whole is surrounded by a membrane just like the cell nucleus is. All structures that form this kind of cell have, on the one hand, Anteile which have a very flexible shape (receptors, ligands) and continuously send and receive signals. On the other hand, they fulfill certain tasks in the cell such as cell respiration or protein biosynthesis. Thus a stream of signals flows through the cell, which leads from the cell nucleus to the environment surrounding the cells and back. In simple terms, it is a never-ending loop. The resulting changing signal patterns influence the specific functional state of the cell. Irrespective of what function a cell has, in principle, all cells work according to the same principle, and because they all work in this way, the cells on the various levels can be influenced in terms of both place and time. Cell growth is thus not a phenomenon that is controlled solely by the cell nucleus and its genetic material. The cell is closely connected to its environment, exchange is narrow and intensive. Not only do signals/impulses/messages from the interior of the cell reach the cell‘s surroundings, thus changing the cell‘s state, but signals/impulses/messages from the environment likewise inlfuence the cell‘s and the nucleus cell‘s function and activity. In this way, the cells and the space between them form an entity of brisk exchange. | 5
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Tumor – see the opportunity

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