Vol 34 No 2 suppli final.pmd - IDA KERALA STATE ::. idakerala.com

Efficacy of bioglass (HABG) grafting over non grafting on mandibular third molar extraction sites
Post operative 6 months with graft Post operative 6 months with out graft
generation composite bioactive material containing Si,
Ca and P made through a non-conventional processing
method - ‘the sol – gel process’. The particle size range
is 1 – 2mm.
The material after passing the screening tests of
haemolysis and cytotoxicity had been subjected to
toxicological studies. All the mandatory tests necessary
have been performed to qualify the materials for
implantation studies. After evaluation of the satisfactory
results of pre- clinical trials, the ethical committee of
Sree Chithra Thirunal Institute of Medical Sciences and
Technology (SCTIMST), Thiruvananthapuram has
approved the use of these materials in human clinical
trials. This material has been used successfully in the
treatment of periodontal infrabony defects.
The purpose of this study is
a. To compare the bone regenerative capacity of
Chitra Hydroxyapatite bioactive glass composite to that
of a non grafted site by radiographic assessment for a
period of 9 months.
b. Clinical assessment of healing.
Patients and methods
Selection of the Patient: Inclusion criteria:
Unremarkable health history, No allergy to the drug
used in the study, Age group 18-30 yrs. Exclusion criteria:
Patients Who smoke, Patients having acute infection,
Clinical parameters: A total of 25 patients with
bilateral mandibular 3rd molar impactions were selected
for the study, with an age range of 18- 30 years. The
nature of the study was explained to the patient and
informed consent was taken before starting the
procedure. Pre operative clinical evaluation was done
to rule out acute inflammation, gingival condition and
oral hygiene status of the patient. Pre operative
radiographs were taken to access the nature of
impaction.
After the surgical removal of impacted tooth the
experimental site A – right side was grafted with Chithra
hydroxyapatite bioglass composite granules (Chithra
HABG), where as the surgical site B – left side, received
no graft. Primary closure of the wound was done. All
patients were evaluated for pain on 3 rd and 7 th day post
operatively. Patients were evaluated for any
inflammation, periodontal pockets distal to mandibular
second molars, pain; dry sockets post operatively.
Post operative radiographs (Orthopantomogram)
were taken on 3 months, 6 months and 9 months interval
to visually evaluate the bone formation in both grafted
and non grafted sites.
Procedure: A standard pre – sterilized minor oral
surgical kit was used for all cases.
Anesthesia: Prior to surgical procedure a mouth
rinse of povidone iodine with water in dilution of 1:5
was given to the patient. The patients were anesthetized
with 2 percent lignocaine hydrochloride with adrenaline
concentration of 1:100000 by giving inferior alveolar
nerve block, 23 anesthetizing inferior alveolar nerve,
lingual nerve and long buccal nerves.
Incision: A standard Terence ward’s incision 24 was
placed in all cases and vertical incisions were also placed.
Utmost care was taken to minimize the trauma to the
soft tissues during reflection of the flap.
Bone removal: Bone removal was done by buccal
guttering technique and was performed using rotary
instruments with proper cooling 25 . Maximum care was
taken to preserve the alveolar bone on the buccal side.
Wherever there was locking of the tooth sectioning of
the tooth was performed with rotary instruments.
Toilet of the wound and hemostasis: Following
delivery of the tooth a thorough toilet of the surgical
wound was done and hemostasis was achieved prior
to placement of the graft material. Any remaining dental
follicle was curetted from the surgical site. 3
Placement of the hydroxy apatite bioglass
granules: The materials were supplied in a sterilized
KDJ - Vol.34, No. 1 Supplement, March 2011
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