COA of 941685-27-4

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Certificate of Analysis
INCB032304
CAS 941685-27-4 Batch No. B15S0913
Product Name
4-(1H-pyrazol-4-yl)-7-((2-
(trimethylsilyl)ethoxy) methyl)- Batch size 800 g
7H-pyrrolo[2,3-d]pyrimidine
MFG. Date Sep.13, 2015 Retest Date Sep.13, 2017
TESTING ITEM SPECIFICATION RESULT
Appearance White powder Conforms
Identification 1H-NMR spectrum Conforms
Purity
HPLC
Storage
BOC Sciences
≥95% 98.01%
Keep in a cool and dry place at room temperature
Result
Correspond
QA:
Jeff Park
QC:
Zoey Tseng
Date:
Sep. 14, 2015
BOC Sciences. Creative Dynamics Inc. All rights reserved.

Data File D:\DATA\RAW DATA\2015-09\DEF_LC2015-09-1412-59-40\092-1101.D
=====================================================================
Acq. Operator : 2015-09 Seq. Line : 11
Acq. Instrument : Instrument 1 Location : Vial 92
Injection Date : 9/14/2015 3:24:37 PM Inj : 1
Inj Volume : 1 µl
Different Inj Volume from Sequence ! Actual Inj Volume : 0.7 µl
Acq. Method : D:\DATA\RAW DATA\2015-09\DEF_LC2015-09-1412-59-40\LC-12MIN-ACID.M
Last changed : 9/6/2015 8:47:13 AM by 2015-09
Analysis Method : D:\DATA\RAW DATA\2015-09\DEF_LC2015-09-1412-59-40\LC-12MIN-ACID.M
Last changed : 9/14/2015 3:41:39 PM by 2015-09
(modified after loading)
Method Info : Instrment: Agilent 1100HPLC
Column:C18 4.6*150mm 5um
Mobile phase:A=0.02% CF3COOH in Water B=ACN
Gradient: 10%-90%B in 6min Flow Rate: 1mL/min
mAU
1000
800
600
400
200
0
*DAD1 B, Sig=254,16 Ref=off (D:\DATA\RAW DATA\2015-09\DEF_LC2015-09-1412-59-40\092-1101.D - D:\DATA\RAW DATA\2015-09\DE
BOC Sciences
0 2 4 6 8 10
6.405
9.158
9.515
11.242
min
=====================================================================
Area Percent Report
=====================================================================
Sorted By : Signal
Multiplier : 1.0000
Dilution : 1.0000
Use Multiplier & Dilution Factor with ISTDs
Instrument 1 9/14/2015 3:41:50 PM 2015-09 Page 1 of 2

Data File D:\DATA\RAW DATA\2015-09\DEF_LC2015-09-1412-59-40\092-1101.D
Signal 1: DAD1 B, Sig=254,16 Ref=off
Signal has been modified after loading from rawdata file!
Peak RetTime Type Width Area Height Area
# [min] [min] [mAU*s] [mAU] %
----|-------|----|-------|----------|----------|--------|
1 6.405 BB 0.0619 4657.47656 1133.94214 98.0105
2 9.158 BB 0.0916 12.38730 1.91217 0.2607
3 9.515 BB 0.0860 22.02720 3.56841 0.4635
4 11.242 BB 0.1549 60.12518 5.70784 1.2653
Totals : 4752.01625 1145.13056
=====================================================================
*** End of Report ***
BOC Sciences
Instrument 1 9/14/2015 3:41:50 PM 2015-09 Page 2 of 2

0
1
2
3
4
5
6
7
8
9
10
11
12
13
14
f1 (ppm)
-5.0E+07
0.0E+00
5.0E+07
1.0E+08
1.5E+08
2.0E+08
2.5E+08
3.0E+08
3.5E+08
4.0E+08
4.5E+08
5.0E+08
5.5E+08
6.0E+08
09-14-2015
400MHz/DMSO-d6
9.00
2.00
2.12
2.01
0.99
1.00
0.95
1.95
0.94
-0.119
0.796
0.816
0.836
2.500
3.390
3.498
3.518
3.538
5.619
7.091
7.100
7.717
7.726
8.349
8.669
8.738
13.409
N
N
N
O
Si
C
H 3 CH 3
C
H 3
NH
N
BOC Sciences