Inhibitors of BOC Sciences

Inhibitors of BOC Sciences
BOC Sciences provides a great number of inhibitor products, from the most common ones to the
ones with rare access in the market.
GSK126
GSK126 effectively inhibits the proliferation of EZH2 mutant DLBCL cell lines and markedly
inhibits the growth of EZH2 mutant DLBCL xenografts in mice. Together, these data demonstrate
that pharmacological inhibition of EZH2 activity may provide a promising treatment for EZH2
mutant lymphoma.
Ibuprofen
An inhibitor of COX-1 and COX-2 with IC50 of 13 μM and 370 μM, respectively.
BIS(1-BUTYLPENTYL) DECANE-1,10-DIYL DIGLUTARATE
Abbreviated as Sec or U, in older publications also as Se-Cys, as a building block of selenoproteins,
this 21st proteinogenic amino acid exists naturally in three domains of life, but not in every
lineage.
Ursodeoxycholic acid
Ursodeoxycholic acid (UDCS) is a cell protectant used extensively to mitigate hepatic and biliary
diseases. Ursodeoxycholic acid may be used to study its specific activities that range from
reduction of cholesterol absorpition, cholesterol gallstone dissolution to suppression of immune
response.IC50: M1-family aminopeptidase: IC50 = 2.6 µM (Plasmodium falciparum 3D7); NTCP:
IC50 = 3.6 µM (human); HCT-116: IC50 = >50 µM (human); GBM: IC50 = >50 µM (human) Asbt:
Ki= 75 µM (human)
Milbemycin Oxime
Prepared by the two natural products, oxidation and oximation, of an 80:20 ratio of milbemycin
A3 and A,Milbemycin oxime is a semi-synthetic macrocyclic lactone. As a nematocide and
insecticide in veterinary medicine,it opens glutamate sensitive chloride channels in neurons of
invertebrates that leads to paralysis by hyperpolarisation of these cells and signal transfer
blocking. M1-family aminopeptidase: IC50 = 2.6 µM (Plasmodium falciparum 3D7); Bile acid
transporter: IC50 = 3.6 µM (human); TGR5: EC5050 = 36.4 µM (human); HCT-116: IC50 >50 µM
(human); GBM: IC50 >50 µM (human)