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Comparison of characteristics, clinical outcomes and cell apoptotic rate parameters group A group B group C P value Age(yr) 29.183.41 29.722.72 29.393.34 0.865 Serum AMH level(ng/mL) 1.650.23 a 4.161.27 6 9.943.67 c
c Physician, Kiryat Ono, Israel; d McGill University- MUHC Reproductive Center, Montreal, QC, Canada; e MUHC Reproductive Center, Monteral, QC, Canada; f Obstetrics and Gynecology, Division of Reproductive Endocrinology and Infertility, McGill University, Montreal, QC, Canada. OBJECTIVE: In the single embryo transfer era many ART cycles results in vitrification of supernumerary embryos to be used in a subsequent vitrified-warmed cycle. The purpose of this study is to determine whether the outcome of the fresh single blastocyst transfer may serve as a prognostic factor for the success of the following vitrified-warmed single blastocyst transfers using sibling embryos from the same cohort. DESIGN: A retrospective cohort study performed at a single academic reproductive center. MATERIALS AND METHODS: All vitrified-warmed single blastocyst transfers conducted at our center between 2012 and 2014 were reviewed. Data about the fresh cycle in which the embryos were created as well as data about the current vitrified-warmed cycle was collected. Pregnancy rate after vitrified-warmed single blastocyst transfers were compared between patients who conceived after the fresh embryo transfer and those who did not. Subgroup analysis according to the fresh cycle outcome (nonpregnant, biochemical pregnancy, miscarriage and live birth) was performed as well. Results were then validated using a logistic regression analysis adjusting for patient’s age, embryo quality and endometrial thickness. RESULTS: During the study period 1429 vitrified-warmed single blastocyst cycles were performed. 302 freeze-all cycles (without fresh transfer) and 123 cycles with more than one embryo transferred in the fresh cycle were excluded from our analysis. A total of 1004 cycles were analyzed: 432 of which the fresh cycle resulted in a pregnancy and 572 fresh cycles ending with a negative pregnancy result. Demographic characteristics and cycle parameters were comparable between the two groups. Pregnancy rates in the vitrified-warmed group performed with sibling embryos of a previously successful fresh cycle were comparable to those performed in patients with a failed fresh transfer. (52.5% vs 56.8 % p¼0.18). However, in subgroup analysis according to the fresh cycles’ outcome (non-pregnant, chemical pregnancy, miscarriage and live birth) higher pregnancy rate were found in the group which achieve live birth in the fresh cycle (53.4% vs. 43.2% p¼0.13 adjusted OR 1.45 95% CI 1.04-2.02). CONCLUSIONS: Live birth achieved after a fresh embryo transfer, may serve as a good prognostic factor for pregnancy in a subsequent vitrifiedwarmed single blastocyst transfer originating from the same cohort of embryos. P-183 Tuesday, October 18, 2016 HIGH PREGNANCY RATES CAN BE ACHIEVED WITH ELEC- TIVE SINGLE EMBRYO TRANSFER OFFERED TO ALL PATIENTS. V. Garzo, a A. Yeo, a I. Su, b H. Cook-Andersen, c D. R. Meldrum, d A. Duleba. e a Reproductive Partners Fertility Center - San Diego, La Jolla, CA; b UC San Diego, San Diego, CA; c Sanford Center for Regenerative Medicine, La Jolla, CA; d Reproductive Partners La Jolla, La Jolla, CA; e Reproductive Medicine, University of California, San Diego, La Jolla, CA. OBJECTIVE: Multiple pregnancies are considered the main complication of IVF. Reluctance to perform elective single embryo transfers (eSET) stems from concerns that pregnancy rates may be unacceptably low for patients and clinicians. This study evaluated success rates of eSET in a single universityaffiliated IVF program. DESIGN: Retrospective cohort. MATERIALS AND METHODS: All patients undergoing IVF in 2014 and with at least two blastocysts were offered eSET, irrespective of age or other prognostic factors at the time of their first embryo transfer (fresh or frozen). All embryo transfers were performed under ultrasound guidance. Clinical pregnancies were verified by identification of gestational sac(s) using transvaginal ultrasound at > 6 weeks of gestation. Statistical analysis included chi-square test and modified Wald method (to identify 95% Confidence Intervals). RESULTS: Among 226 first embryo transfers eSET was performed in 181 cases (80%). Preimplantation Genetic Screening was performed in 97 cases (54% of eSETs). Comparable clinical pregnancy rates per transfer were achieved in all age groups (p¼0.56). Singleton pregnancies were identified in 123 patients (96% of eSET pregnancies), four patients had twin pregnancies and one patient had identical triplets. CONCLUSIONS: A policy of offering eSET to all patients irrespective of their prognostic factors resulted in high clinical pregnancy rate (70%) with Age Group (Years) minimal risk of multiple pregnancies (4%). eSET is a valid and safe option for a majority of patients undergoing IVF. P-184 Tuesday, October 18, 2016 INCREASED RATE OF ADVERSE NEONATAL OUTCOMES AMONG TWINS FOLLOWING ASSISTED REPRODUCTIVE TECHNOLOGY. A. Y. Wang. Faculty of Health, University of Technology Sydney, Ultimo NSW, Australia. OBJECTIVE: The literature is inconsistent regarding the association between assisted reproductive technology (ART) and twin outcomes. This study using a population approach investigates the maternal and neonatal outcomes between ART and non-ART twins. DESIGN: A retrospective population cohort study using data from the National Perinatal Data Collections. The study included 19,662 twins born in Victoria, Queensland, Western Australia, Tasmania and the Australian Capital Territory between 2007 and 2011 in Australia. MATERIALS AND METHODS: The analysis included 2290 (23.3%) ART twin sets and 7541 (76.7%) non-ART twin sets. Maternal and pregnancy characteristics were compared between ART and non-ART twin sets. The rates of adverse perinatal outcomes were compared between ART and non- ART twins. Chi-squared test and Student’s t-test were used for categorical and continuous variables respectively. Generalized Estimating Equations was used to assess the likelihood of any neonatal outcomes following ART, with adjusted odds ratio (AOR) and 95% confidence intervals (CI) presented. Weinberg’s differential rule was used to estimate the rate of monozygotic twins. RESULTS: ART mothers were 3.3 years older than non-ART mothers. Compared to non-ART mothers, higher proportions of ART mothers were primiparous, non-smoking, with normal BMI and with private health insurance. The rates of pregnancy-induced hypertension and gestational diabetes were slightly higher for ART mothers than non-ART mothers (12.2% vs. 8.4%) and (9.7% vs. 7.5%) respectively. Compared with non-ART twins, ART twins had higher rates of preterm birth (61.5% vs. 56.9% p
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Supplement to: VOL. 106 NO. 3S SEPT
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The first six papers are candidates
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in follicular fluid from small antr
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MATERIALS AND METHODS: Letrozole/FS
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expulsion rates were 3.7% for both
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exposure continues to be a major pu
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were no statistically significant d
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References: 1. Br€annstr€om M,
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O-38 Monday, October 17, 2016 11:30
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the embryo was based solely upon th
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ART: CLINICAL 1 O-49 Monday, Octobe
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Odds of Term LBW According to Vario
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ETof male vs. female embryos: patie
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Differences in Outcomes between Day
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eaching the blastocyst stage by Day
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TIMING OF FERTILITY PRESERVATION Va
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References: 1. McLaughlin T, Lamend
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chromosomal status of embryos and,
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OBJECTIVE: To longitudinally assess
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clinical parameters as well as the
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sought out medical tourism in the C
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animals between 7 and 13 days and t
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MALE REPRODUCTION AND UROLOGY: CLIN
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O-114 Tuesday, October 18, 2016 12:
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P on quantitative immunoblotting co
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mated on day 28 post-BMT. In a sepa
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decreased but DETs were predominant
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OBJECTIVE: To evaluate pregnancy an
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pregnancy, live birth rate and misc
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Day 3 ‘‘no result’’embryos
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financial support, mostly from fami
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G. D. Palermo. Reproductive Medicin
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OUTCOME PREDICTORS: ART 2 O-169 Tue
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and the X 2 test was used for categ
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Table 1. Fresh vs. elective FET in
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Table 1: SA Parameters and Cycle Ty
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(ANOVA) of the degree and distribut
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line stem cells referred to ovarian
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that patients with EGT have poor GU
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microvessel density (MVD) of breast
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step of culture significantly impro
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syndrome and other chromosome abnor
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ate while minimizing the multiple b
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CLINICAL REPRODUCTIVE LABORATORY O-
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14. Ombelet W, Vandeput H, Van de P
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Mean 12-month costs in 2014 $ (SD)
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(HMB) and tumor size. We report the
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RESULTS: Gross inspection of the tr
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RESULTS: A total of 39,643 cycles b
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stimulation (p
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eSET with 1 embryo frozen No. Live
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previously demonstrated, in our mou
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(25%). Fertilization and cleavage r
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MATERIALS AND METHODS: 197 men from
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to respond and offer support and re
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questionnaire. Baseline demographic
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DESIGN: Descriptive analysis of bas
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(IFU) accompanying the demonstratio
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(0.3, 2.9), and median (IQR) BW was
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Page 131 and 132: P-62 Tuesday, October 18, 2016 INFE
Page 133 and 134: Current State of OT with Cryopreser
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Page 141 and 142: maternal age, ovulation trigger dru
Page 143 and 144: Table 1. Fresh vs. Freeze-all in po
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Page 147 and 148: vs 43%, 78/183, respectively). With
Page 149 and 150: P-110 Tuesday, October 18, 2016 COR
Page 151 and 152: P-116 Tuesday, October 18, 2016 EVO
Page 153 and 154: OBJECTIVE: To determine if embryo m
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Page 163 and 164: DESIGN: Retrospective data analysis
Page 165 and 166: 4. Vaccari, S., J. Conaghan, and P.
Page 167 and 168: P-161 Tuesday, October 18, 2016 TOT
Page 169 and 170: Risks of Adverse Outcomes Compared
Page 171 and 172: CONCLUSIONS: Even though all study
Page 173: P-178 Tuesday, October 18, 2016 ARE
Page 177 and 178: DESIGN: This was a multicentre retr
Page 179 and 180: Live Birth Rates (LBR, %) and Multi
Page 181 and 182: on first-trimester ultrasound were
Page 183 and 184: Outcomes by number of blastocysts i
Page 185 and 186: P-209 Tuesday, October 18, 2016 OOC
Page 187 and 188: Demographic Characteristics and Lab
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Page 191 and 192: Table 1: There is no difference in
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Page 197 and 198: CONCLUSIONS: Despite similar embryo
Page 199 and 200: CONCLUSIONS: Despite prior speculat
Page 201 and 202: P-249 Tuesday, October 18, 2016 CLI
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Page 205 and 206: Live singleton births after fresh v
Page 207 and 208: Patients with a second STEET after
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Page 215 and 216: MATERIALS AND METHODS: Women with r
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Page 223 and 224: RESULTS: CE of RS-ost is summarized
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consecutive cases were made during
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OBJECTIVE: To evaluate reproductive
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A: 43 %1% (n¼101) // >4% (n¼235)
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of the patients. In the same period
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factor (group 1A, malesyears old),
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K. B. Bjugstad, e K. Khalafalla, f
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16% had unpaired XY. Only 25% of sp
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genomic hybridization (aCGH). Copy
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treatment parameters. Age and FSH a
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absorptiometry (DXA) allows for hig
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transfer of three or more morpholog
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OBJECTIVE: Recently high powered st
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circadian clock may be related with
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young adult female monkeys. Am J Ph
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of oligo-ovulation in some patients
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volume (OV) > 10cm 3 . The data to
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P-398 Wednesday, October 19, 2016 S
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and had a live birth in the last tw
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continued to the day of oocyte pick
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P-415 Wednesday, October 19, 2016 I
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P-421 Wednesday, October 19, 2016 H
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telomere length, telomere aggregate
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P-433 Wednesday, October 19, 2016 G
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DESIGN: This prospective single-cen
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of epithelial and stromal cells in
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P-448 Wednesday, October 19, 2016 E
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P-453 Wednesday, October 19, 2016 I
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assigned to their matched controls.
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activity. CCL25 promotes invasion o
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end of the 3-month treatment (n ¼
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the testis, and agglomerates of AgN
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is related to exponential increase
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are found only in the 20-hour group
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OBJECTIVE: The growing interest in
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Changes with LIVE Technique with Ti
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P-497 Wednesday, October 19, 2016 O
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MATERIALS AND METHODS: Healthy men
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DESIGN: Retrospective medical recor
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likely to have ever been employed b
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may be most apropos in patients wit
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pathologies. Unique findings of the
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RESULTS: Pregnancy rates (PR) and l
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Direct division from 1 to 3 cells e
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5. Spandorfer SD, Clarke R, Bovis L
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P-545 Wednesday, October 19, 2016 U
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Scion-Image software was used to me
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tween basal inhibin B levels and th
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measurements were retrospectively m
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ART - CLINICAL P-565 Wednesday, Oct
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Relative risk of donor cycle outcom
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RESULTS: We found that the noncompl
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the literature to identify characte
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RESULTS: There were 274 clinics wit
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Miscarriage rates were 16.9% 95%CI(
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syndrome: two distinct entities wit
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conflicting results in the current
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RESULTS: Average age of oocyte dono
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I. Kang, b T. K. Yoon, b H. Song. a
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Surprisingly, out of 32 cases, 19 (
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Reproductive Science, Icahn School
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Primary diagnosis GnRH antagonist c
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of infertility, indications for IVF
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P-640 Wednesday, October 19, 2016 A
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were made using Prism software. Stu
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CONCLUSIONS: Faster progression to
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using a time-lapse embryo monitorin
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drops may stress embryos and could
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trophectoderm biopsy and analyzed v
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abnormal and these zygotes should b
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knocked-down TP53 in two WT hESC li
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Doctors should be able to help tran
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2004-2013 White Asian Black Hispani
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compared with the PGD group. Chromo
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lastocysts), was calculated at 50%,
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MATERIALS AND METHODS: The patient
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AUTHOR INDEX Abbas, A., P-303, P-30
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Camargo, M., P-505 Camarillo, D. B.
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Fernandez, I., O-115 Fernandez, P.,
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Ismail, A. M., P-235, P-400, P-415
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Lo, K., O-153 Lonczak, A., O-56 Lon
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Palmor, M., P-161 Palomaki, G. E.,
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Sharma, P. A., P-359 Sharma, R., O-
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Wesselink, A., O-195 Wessels, C. E.
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P-404, P-405, P-408, P-409, P-411,
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Berro, R. Berwald, T. Bjugstad, K.
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Feinberg, R. F. Fields, R. A. Foida
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Leone Roberti Maggiore, U. DEKA, Sp
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Ready, K. Counsyl, Full-time compan
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Wells, D. Reprogenetics UK, Direct
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