Volker Vallon, M.D. - Division of Nephrology-Hypertension - UC San ...
Volker Vallon, M.D. - Division of Nephrology-Hypertension - UC San ...
Volker Vallon, M.D. - Division of Nephrology-Hypertension - UC San ...
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CURRICULUM VITAE<br />
<strong>Volker</strong> <strong>Vallon</strong>, M.D.<br />
Office Address: University <strong>of</strong> California <strong>San</strong> Diego<br />
Department <strong>of</strong> Medicine and<br />
Department <strong>of</strong> Pharmacology<br />
<strong>Division</strong> <strong>of</strong> <strong>Nephrology</strong> & <strong>Hypertension</strong><br />
& VA <strong>San</strong> Diego Health Care System<br />
3350 La Jolla Village Drive (9151)<br />
<strong>San</strong> Diego, CA 92161<br />
Phone: 858-552-8585 X5945<br />
E-mail: vvallon@ucsd.edu<br />
Date <strong>of</strong> Birth: November 11, 1964<br />
Place <strong>of</strong> Birth: Stockach, Baden, Germany<br />
Marital Status: married, 2 daughters<br />
Education, Training, and Positions:<br />
7/2010 – today Pr<strong>of</strong>essor <strong>of</strong> Medicine and Pharmacology<br />
Divison <strong>of</strong> <strong>Nephrology</strong> & <strong>Hypertension</strong>, Department <strong>of</strong> Medicine, and<br />
Department <strong>of</strong> Pharmacology, University <strong>of</strong> California <strong>San</strong> Diego<br />
10/2003 – today Principal Investigator, VA <strong>San</strong> Diego Health Care System<br />
10/2003 – 6/2010: Associate Pr<strong>of</strong>essor <strong>of</strong> Medicine and Pharmacology<br />
Divison <strong>of</strong> <strong>Nephrology</strong> & <strong>Hypertension</strong>, Department <strong>of</strong> Medicine, and<br />
Department <strong>of</strong> Pharmacology, University <strong>of</strong> California <strong>San</strong> Diego<br />
11/1998 -9/2003: Lecturer (“Privatdozent”)<br />
Dept. <strong>of</strong> Pharmacology, University <strong>of</strong> Tübingen<br />
5/1999 - 11/1999: Visiting Scientist / Courtesy Associate<br />
National Institute <strong>of</strong> Diabetes and Digestive and Kidney Disease (NIDDK),<br />
National Institutes <strong>of</strong> Health (NIH), Bethesda, MD<br />
(J. Schnermann, M.D.; J. Briggs, M.D.)<br />
11/1998: Habilitation in Pharmacology and Toxicology, University <strong>of</strong> Tübingen
5/1998: Board Certification as a Physician for Pharmacology and<br />
Toxicology, Baden-Württemberg, Germany<br />
7/1995 - 11/1998: Research Associate<br />
Dept. <strong>of</strong> Pharmacology, University <strong>of</strong> Tübingen (H. Osswald, M.D.)<br />
2<br />
V. <strong>Vallon</strong><br />
7/1993 - 6/1995: Postdoctoral Research Fellow (German Research Foundation) Dept.<br />
<strong>of</strong> Medicine, Div. <strong>of</strong> <strong>Nephrology</strong> and <strong>Hypertension</strong>, University <strong>of</strong> California<br />
<strong>San</strong> Diego CA, (R.C. Blantz, M.D.)<br />
1/1992 - 6/1993: Postdoctoral Fellow<br />
Experimental and Clinical Pharmacology, Dept. <strong>of</strong> Pharmacology,<br />
University <strong>of</strong> Tübingen (H. Osswald, M.D.) and Dept. <strong>of</strong> Internal Medicine<br />
(T. Risler, M.D.)<br />
11/1991: Licenced as a physician<br />
1990 - 1991: Praktisches Jahr, Internship, University <strong>of</strong> Tübingen<br />
1989 – 5/1992: Doctoral thesis, Dept. <strong>of</strong> Medicine, Institute <strong>of</strong> Occupational Medicine,<br />
University <strong>of</strong> Tübingen (F.W. Schmahl, M.D.)<br />
1985 - 1991: Medical School, University <strong>of</strong> Tübingen, Germany<br />
1984 - 1985: Military service, Ulm, Germany<br />
1975 - 1984: Johannes Kepler Gymnasium, Weil der Stadt, Germany<br />
<strong>San</strong> Diego, Juli 2010 <strong>Volker</strong> <strong>Vallon</strong>, M.D.
MEMBER OF EDITORIAL BOARD:<br />
- Nephron Physiology (since 2003)<br />
- Kidney and Blood Pressure Research (since 2003)<br />
- Pfluger=s Archives - European Journal <strong>of</strong> Physiology (2004-2007)<br />
- American Journal <strong>of</strong> Physiology – Renal Physiology (since 2007)<br />
- The Open Urology and <strong>Nephrology</strong> Journal (since 2008)<br />
GRANT REVIEW COMMITTEES:<br />
3<br />
V. <strong>Vallon</strong><br />
- The Wellcome Trust, London (2004-2006,2008)<br />
- Kidney Research UK, London (2007)<br />
- Veterans Affairs (VA) Merit Review Board - Renal Section, Washington D.C. (2007-2010)<br />
- American Heart Association, Cardiorenal Study Section, Dallas (since 2007)<br />
- Israel Science Foundation, Jerusalem (2008)<br />
- NIH, Pathobiology <strong>of</strong> Kidney Diseases (PBKD) Study Section, Washington D.C. (2010)<br />
AWARDS AND HONORS:<br />
- Travel Fellowship, XII Int. Congress <strong>of</strong> Int. Soc. <strong>of</strong> Nephrol., Jerusalem, Israel (1993)<br />
- Fellowship, German Research Association (DFG), <strong>UC</strong> California <strong>San</strong> Diego (1993-1995)<br />
- Trainee Investigator Award, American Society for Clinical Investigation (1994)<br />
- Consultant, <strong>UC</strong> <strong>San</strong> Diego, Dept. Medicine, Div. <strong>Nephrology</strong> and <strong>Hypertension</strong> (1998)<br />
- Best Poster Award, German Society <strong>of</strong> Pharmacology and Toxicology, Mainz (1999, 2003)<br />
- Courtesy Associate, National Institute <strong>of</strong> Diabetes and Digestive and Kidney Disease<br />
(NIDDK), National Institutes <strong>of</strong> Health (NIH), Bethesda, MD (1999)<br />
- Best Poster Award, German Soc. Nephrol., Münster (2001), Basel (2004), Tübingen (2008)<br />
- Poster Award, World Congress <strong>of</strong> <strong>Nephrology</strong>, Berlin (2003)<br />
- New Investigator Award in Regulatory and Integrative Physiology; Water and Electrolyte<br />
Homeostasis Section, American Physiological Society, Washington (2004)<br />
- Young Investigator Award for Excellence in Renal Physiology; Renal Section, American<br />
Physiological Society, Washington (2007)
PROFESSIONAL COMMITTEE SERVICES:<br />
4<br />
V. <strong>Vallon</strong><br />
- Chair oral scientific session, Annual Meeting, German Society <strong>of</strong> <strong>Nephrology</strong> (2001)<br />
- Chair poster session, Annual Meeting, German Physiological Society (2002)<br />
- Abstract reviewer, Annual Meeting, American Society <strong>of</strong> <strong>Nephrology</strong> (2002)<br />
- Abstract reviewer, Annual Meeting, German Society <strong>of</strong> <strong>Nephrology</strong> (2002)<br />
- Chair oral scientific session, Annual Meeting <strong>of</strong> the ASN (2002)<br />
- Chair oral session, Annual Meeting, German Society <strong>of</strong> Pharmacology & Toxicology (2003)<br />
- Abstract reviewer, Annual Meeting, American Heart Association (2003)<br />
- Chair oral scientific session, Experimental Biology Meeting FASEB (2004)<br />
- Abstract reviewer, Annual Meeting, American Heart Association (2004)<br />
- Chair oral session, Annual Meeting, German Society <strong>of</strong> Pharmacology & Toxicology (2005)<br />
- Abstract reviewer, Annual Meeting, American Heart Association (2005)<br />
- Abstract reviewer, Annual Meeting, American Heart Association (2006)<br />
- Chair oral & poster session, Int. Society <strong>of</strong> <strong>Hypertension</strong>, Symposium, Tokyo (2006)<br />
- Chair oral session, Workshop, Mathematical Biosciences Institute, Ohio (2007)<br />
- Member, Inst. Animal Care and Use Committee, VA Medical Center, <strong>San</strong> Diego (2007- )<br />
- Abstract reviewer, ISN World Congress in <strong>Nephrology</strong>, Rio de Janeiro (2007)<br />
- Chair and organizer, oral session, Experimental Biology Meeting FASEB (2007)<br />
- Abstract reviewer, Annual Meeting, American Society <strong>of</strong> <strong>Nephrology</strong> (2008)<br />
- Faculty, Annual Meeting, American Society <strong>of</strong> <strong>Nephrology</strong> (2008)<br />
- Chair 2 oral scientific sessions, Annual Meeting, American Society <strong>of</strong> <strong>Nephrology</strong> (2008)<br />
- Abstract reviewer, ISN World Congress in <strong>Nephrology</strong>, Milan (2009)<br />
- Vice chair, Inst. Animal Care and Use Committee, VA Medical Center, <strong>San</strong> Diego (2009- )<br />
- Renal Section Award Committee; American Physiological Society, Bethesda (2009- )<br />
- Faculty, Annual Meeting, American Society <strong>of</strong> <strong>Nephrology</strong> (2010)<br />
- Chair oral scientific session, Annual Meeting, German Society <strong>of</strong> <strong>Nephrology</strong> (2010)<br />
- Renal Section Steering Cmte, Awards Co-Chair, American Physiological Society (2010- )
GRANT SUPPORT (completed):<br />
Deutsche Forschungsgemeinschaft DFG Va 118/2-1 - Principal Investigator<br />
Time: 7/1993-6/1995<br />
Topic: Physiology and pathophysiology <strong>of</strong> renal hemodynamics and tubular<br />
reabsorption (at University <strong>of</strong> California <strong>San</strong> Diego)<br />
5<br />
V. <strong>Vallon</strong><br />
Deutsche Forschungsgemeinschaft DFG Va 118/3-1 - Principal Investigator<br />
Time: 12/1995-11/1997<br />
Topic: Glomerular hyperfiltration and renal growth in experimental diabetes mellitus:<br />
role <strong>of</strong> tubular reabsorption<br />
Deutsche Forschungsgemeinschaft DFG Os 42/9-1<br />
Time: 12/1996-11/1998<br />
Topic: Experiments on ATP-sensitive potassium channels in the tubular system <strong>of</strong> the<br />
kidney<br />
University <strong>of</strong> Tübingen, fortüne (Nr. 427) - Principal Investigator<br />
Time: 1/1998-1/1999<br />
Topic: Is<strong>of</strong>orms <strong>of</strong> protein kinase C in the kidney <strong>of</strong> diabetic rats<br />
Federal Ministry <strong>of</strong> Education, Science, Research and Technology BMBF 01 KS 9602 – Co-PI<br />
Time: 7/1996-6/1999<br />
Topic: Pathophysiology <strong>of</strong> tubular transport mechanisms in arterial hypertension and<br />
diabetic nephropathy<br />
Deutsche Forschungsgemeinschaft DFG Va 118/4-1 - Principal Investigator<br />
Time: 5/1999-11/1999<br />
Topic: Micropuncture technique and molecular biology in mice (at the National Institute<br />
<strong>of</strong> Diabetes and Digestive and Kidney Disease (NIDDK), National Institutes <strong>of</strong><br />
Health (NIH), Bethesda, MD)<br />
Federal Ministry <strong>of</strong> Education, Science, Research and Technology BMBF 01 EC 9405 – Co-PI<br />
Time: 4/1996-3/2000<br />
Topic: Pathophysiology <strong>of</strong> glomerular hyperfitration in diabetes mellitus<br />
Deutsche Forschungsgemeinschaft DFG Va 118/3-2 - Principal Investigator<br />
Time: 12/1998-5/2001<br />
Topic: Role <strong>of</strong> beta Is<strong>of</strong>orms <strong>of</strong> protein kinase C in diabetic nephropathy<br />
Hoechst Marion Roussel; Disease Group Cardiovascular; Germany - Principal Investigator<br />
Time: 4/1999-3/2000<br />
Topic Effect <strong>of</strong> selective inhibitors <strong>of</strong> NHE1, NHE2 and NHE3 on tubular reabsorption<br />
and tubuloglomerular feedback<br />
Federal Ministry <strong>of</strong> Education, Science, Research and Technology BMBF 01 KS 9602 – Co-PI<br />
Time: 7/1999-6/2002<br />
Topic: Control <strong>of</strong> renin secretion and renal hemodynamics in diabetes mellitus<br />
Deutsche Forschungsgemeinschaft DFG Va 118/3-2 - Principal Investigator<br />
Time: 4/2000<br />
Topic: Traveling support<br />
- National Institutes <strong>of</strong> Health, Bethesda<br />
- Yale University, New Haven<br />
- Experimental Biology Meeting, <strong>San</strong> Diego
GRANT SUPPORT (completed): (continued)<br />
Dr. Karl-Kuhn-Stiftung - Principal Investigator<br />
Time: 8/1999-7/2000<br />
Topic: Micropuncture studies in transgenic mice<br />
Schwarz Pharma AG; Monheim, Germany - Principal Investigator<br />
Time: 3/2000-12/2000<br />
Topic New pharmacological approaches in nephroprotection<br />
Aventis Pharma; Disease Group Cardiovascular; Germany - Principal Investigator<br />
Time: 6/2000-12/2000<br />
Topic New pharmacological approaches in hypertension<br />
Dr. Karl-Kuhn-Stiftung - Principal Investigator<br />
Time: 10/2000-9/2001<br />
Topic: Micropuncture studies in IsK and TWIK-1 knockout mice<br />
Aventis Pharma; Disease Group Cardiovascular; Germany - Principal Investigator<br />
Time: 2/2001-8/2001<br />
Topic New pharmacological approaches in hypertension<br />
6<br />
V. <strong>Vallon</strong><br />
Deutsche Forschungsgemeinschaft DFG Va 118/7-1 - Principal Investigator<br />
Time: 10/2000-5/2003<br />
Topic: Role <strong>of</strong> potassium channels for tubular transport in the kidney: studies in IsK<br />
and TWIK-1 knockout mice<br />
University <strong>of</strong> Tübingen, fortüne (Nr. 427) - Principal Investigator<br />
Time: 8/2001-7/2003<br />
Topic: Protein kinase C is<strong>of</strong>orms alpha , beta 1 and beta 2 in the kidney <strong>of</strong> the mouse:<br />
localization and expression in experimental diabetes mellitus<br />
Federal Ministry <strong>of</strong> Education, Science, Research and Technology BMBF - Principal Investigator<br />
Time: 7/2002-6/2005<br />
Topic: Serum- and glucocorticoid-regulated kinase 1 (SGK1) in the control <strong>of</strong> renal<br />
electrolyte excretion and pathogenesis <strong>of</strong> arterial hypertension<br />
Deutsche Forschungsgemeinschaft DFG Ri 1535/3-1/2 - Mentor<br />
Time: 5/2004-4/2007<br />
Topic: Fellowship for Dr Timo Rieg to join my lab at <strong>UC</strong> <strong>San</strong> Diego<br />
NIH-R21DK070667 - Co-Investigator (PI: Joseph Satriano, <strong>UC</strong>SD)<br />
Time: 04/2006-03/2008<br />
Topic: Functional Consequences <strong>of</strong> Early Diabetic Kidney Growth<br />
NIH-R01 GM66232 – Co-investigator (PI: Paul Insel, <strong>UC</strong>SD)<br />
Time: 10/2004-9/2008<br />
Topic: Adrenergic and Purinergic Regulation <strong>of</strong> Target Cells<br />
Takeda Pharma – Principal Investigator<br />
Time: 07/06-06/08<br />
Topic: Renal Effects <strong>of</strong> Pioglitazone<br />
AHA-Grant in Aid 655232Y – Principal Investigator<br />
Time: 07/06-06/08<br />
Topic: Mechanism <strong>of</strong> Thiazolidinedione-induced Fluid Retention in the Kidney
GRANT SUPPORT (completed) (continued)<br />
National Kidney Foundation – Mentor<br />
Time: 07/08-06/09<br />
Topic: Fellowship for Dr Timo Rieg<br />
NIH-R01DK56248 – Co-investigator (PI: Scott Thomson, <strong>UC</strong>SD)<br />
Time: 04/2005-3/2010<br />
Topic: Glomerular and Tubular Function in the Diabetic Kidney<br />
Bristol-Myers Squibb – Principal Investigator<br />
Time: 05/08-04/10<br />
Topic: Sodium-Glucose Transport and Physiology <strong>of</strong> the Diabetic Kidney<br />
7<br />
V. <strong>Vallon</strong>
CURRENT GRANT SUPPORT<br />
NIH-R01DK28602 - Co-Investigator (PI: Roland Blantz, <strong>UC</strong>SD)<br />
Time: 02/07-01/12<br />
Topic: Autoregulation <strong>of</strong> Glomerular Filtration Rate<br />
8<br />
V. <strong>Vallon</strong><br />
NIH-P30DK079337 – Co-investigator (O’Brien Core Center)<br />
Time: 09/08-7/13<br />
Topic: University <strong>of</strong> Alabama-<strong>UC</strong> <strong>San</strong> Diego O’Brien Core Center for Acute Kidney<br />
Injury Research<br />
NIH-R01DK079784 – Co-Investigator (PI: <strong>San</strong>jay Nigam, <strong>UC</strong>SD)<br />
Time: 3/08-02/12<br />
Topic: Mechanism <strong>of</strong> fetal and neonatal handling <strong>of</strong> HIV drugs<br />
NIH-R01GM66232-05 – Co-investigator (PI: Paul Insel, <strong>UC</strong>SD)<br />
Time: 08/2009-07/2011<br />
Topic: Adrenergic and Purinergic Regulation <strong>of</strong> Target Cells<br />
Takeda Pharma – Principal Investigator<br />
Time: 03/10-03/12<br />
Topic: Alogliptin Effects on the Kidney<br />
NIH-R01HL094728 – Principal Investigator (Co-PI: Satish Eraly, <strong>UC</strong>SD)<br />
Time: 06/10-04/15<br />
Topic: Blood Pressure Regulation by OAT3<br />
AHA-10GRNT3440038 – Principal Investigator<br />
Time: 07/10-06/12<br />
Topic: Role <strong>of</strong> epithelial sodium channel in thiazolidinedione-induced fluid retention<br />
Bristol-Myers Squibb – Principal Investigator (Co-PI: Kumar Sharma, <strong>UC</strong>SD)<br />
Time: 07/10-06/12<br />
Topic: Glucose toxicity and SGLT in Diabetic Kidney Disease
PUBLICATIONS<br />
Doctoral Thesis:<br />
9<br />
V. <strong>Vallon</strong><br />
An oral fat tolerance test in 40- 50 year old healthy male volunteers to determine postprandial<br />
serum lipid and lipoprotein levels and to test the reproducibility <strong>of</strong> postprandial serum<br />
triglyceride pr<strong>of</strong>iles.<br />
University <strong>of</strong> Tübingen, 1992. - magna cum laude -<br />
Original publikations:<br />
1. <strong>Vallon</strong> V, Osswald H. Dipyridamole prevents diabetes-induced alterations <strong>of</strong> kidney function<br />
in rats.<br />
Naunyn-Schmiedeberg's Arch Pharmacol 349:217-222, 1994.<br />
2. <strong>Vallon</strong> V, Wead LM, Blantz RC. Renal hemodynamics and plasma and kidney angiotensin<br />
II in established diabetes mellitus in rats: effect <strong>of</strong> sodium and salt restriction.<br />
J Am Soc Nephrol 5:1761-1767, 1995.<br />
3. <strong>Vallon</strong> V, Blantz RC, Thomson SC. Homeostatic efficiency <strong>of</strong> tubuloglomerular feedback is<br />
reduced in established diabetes mellitus in rats.<br />
Am J Physiol 269: F876-F883, 1995.<br />
4. Thomson SC, <strong>Vallon</strong> V. Alpha-2-adrenoceptors determine the response to nitric oxide<br />
inhibition in the rat glomerulus and proximal tubule.<br />
J Am Soc Nephrol 6:1482-1490, 1995.<br />
5. <strong>Vallon</strong> V, Thomson SC. Inhibition <strong>of</strong> local nitric oxide synthase increases homeostatic<br />
efficiency <strong>of</strong> tubuloglomerular feedback.<br />
Am J Physiol 269: F892-F899, 1995.<br />
6. <strong>Vallon</strong> V, Thomson S, Peterson OW, Gabbai FB, Blantz RC. Interactive control <strong>of</strong> renal<br />
function by �2-adrenergic system and nitric oxide: role <strong>of</strong> angiotensin II.<br />
J Cardiovasc Pharmacol 26:916-922, 1995.<br />
7. Thomson SC, Blantz RC, <strong>Vallon</strong> V. Increased tubular flow induces resetting <strong>of</strong><br />
tubuloglomerular feedback.<br />
Am J Physiol 270: F461-F468, 1996.<br />
8. Lortie MJ, Novotny WF, Peterson OW, <strong>Vallon</strong> V, Malvey K, Mendonca M, Satriano J, Insel<br />
P, Thomson SC, Blantz RC. Agmatine, a bioactive metabolite <strong>of</strong> arginine: production,<br />
degradation, and functional effects in the kidney <strong>of</strong> the rat.<br />
J Clin Invest 97:413-420, 1996.<br />
9. Thomson S, <strong>Vallon</strong> V, Blantz RC. Asymmetry <strong>of</strong> tubuloglomerular feedback effector<br />
mechanism with respect to ambient tubular flow.<br />
Am J Physiol 271: F1123-F1130, 1996.<br />
10. <strong>Vallon</strong> V, Kirschenmann D, Wead LM, Lortie MJ, Satriano J, Blantz RC, Thomson SC.<br />
Effect <strong>of</strong> chronic salt loading on kidney function in early and established diabetes mellitus in<br />
rats.<br />
J Lab Clin Med 130:76-82, 1997.<br />
11. <strong>Vallon</strong> V, Richter K, Heyne N, Osswald H. Effect <strong>of</strong> intratubular application <strong>of</strong> angiotensin 1-<br />
7 on nephron function.<br />
Kidney Blood Press Res 20:233-239, 1997.
Original publications: (continued)<br />
10<br />
V. <strong>Vallon</strong><br />
12. Thomson SC, <strong>Vallon</strong> V, Blantz RC. Reduced proximal reabsorption resets tubuloglomerular<br />
feedback in euvolemic rats.<br />
Am J Physiol 273:R1414-R1420, 1997.<br />
13. <strong>Vallon</strong> V, Osswald H, Blantz RC, Thomson SC. Potential role <strong>of</strong> luminal potassium in<br />
tubuloglomerular feedback.<br />
J Am Soc Nephrol 8:1831-1837, 1997.<br />
14. Mühlbauer B, Luippold G, <strong>Vallon</strong> V, Russ H, Osswald H, Schömig E. Disprocynium24<br />
induces a dopamine-independent eukaliuric natriuresis in the anesthetized rat.<br />
Naunyn-Schmiedeberg's Arch Pharmacol 356:846-849, 1997.<br />
15. <strong>Vallon</strong> V, Heyne N, Richter K, Khosla MC, Fechter K. [7-D-Ala]-angiotensin 1-7 blocks renal<br />
actions <strong>of</strong> angiotensin 1-7 in the anesthetized rat.<br />
J Cardiovasc Pharmacol 32:164-167, 1998.<br />
16. <strong>Vallon</strong> V, Kirschenmann D, Brenner I, Albinus M, Osswald H. Potassium diet as a<br />
determinant for the renal response to systemic potassium channel modulation in<br />
anesthetized rats.<br />
Naunyn-Schmiedeberg's Arch Pharmacol 358:245-252, 1998.<br />
17. <strong>Vallon</strong> V, Richter K, Osswald H, Schömig E, Mühlbauer B. Eukaliuric natriuresis and<br />
diuresis in response to disprocynium24: studies on the tubular site <strong>of</strong> action.<br />
Naunyn-Schmiedeberg's Arch Pharmacol 358:238-244, 1998.<br />
18. <strong>Vallon</strong> V, Albinus M, Blach D. Effect <strong>of</strong> KATP channel blocker U37883A on renal function in<br />
experimental diabetes mellitus.<br />
J Pharmacol Exp Ther 286:1215-1221, 1998.<br />
19. Huang DY, Osswald H, <strong>Vallon</strong> V. Intratubular application <strong>of</strong> sodium azide inhibits loop <strong>of</strong><br />
Henle reabsorption and tubuloglomerular feedback response in anesthetized rats.<br />
Naunyn-Schmiedeberg's Arch Pharmacol 358:367-373, 1998.<br />
20. Pfaff IL, Wagner H-J, <strong>Vallon</strong> V. Immunolocalization <strong>of</strong> protein kinase C isoenzymes �, �I and<br />
�II in rat kidney.<br />
J Am Soc Nephrol 10, 1861-1873, 1999.<br />
21. Huang DY, Osswald H, <strong>Vallon</strong> V. Eukaliuric natriuresis and diuresis in response to the KATP<br />
channel blocker U37883A: micropuncture studies on the tubular site <strong>of</strong> action.<br />
Br J Pharmacol 127: 1811-1818, 1999.<br />
22. <strong>Vallon</strong> V, Richter K, Blantz RC, Thomson S, Osswald H. Glomerular hyperfiltration in<br />
experimental diabetes mellitus: potential role <strong>of</strong> tubular reabsorption.<br />
J Am Soc Nephrol 10: 2569-2576, 1999.<br />
23. <strong>Vallon</strong> V, Schwark J-R, Richter K, Hropot M. Role <strong>of</strong> Na + /H + exchanger NHE3 in nephron<br />
function: micropuncture studies with S3226, an inhibitor <strong>of</strong> NHE3.<br />
Am J Physiol: Renal Physiol 278: F375-F379, 2000.<br />
24. Luippold G, Schneider S, <strong>Vallon</strong> V, Osswald H, Mühlbauer B. Postglomerular<br />
vasoconstriction induced by dopamine D3 receptor activation in anesthetized rats.<br />
Am J Physiol: Renal Physiol 278:F570-F575, 2000.
Original publications: (continued)<br />
25. <strong>Vallon</strong> V, Verkman AS, Schnermann J. Luminal hypotonicity in proximal tubules <strong>of</strong><br />
aquaporin1 knockout mice.<br />
Am J Physiol: Renal Physiol 278:F1030-F1033, 2000.<br />
11<br />
V. <strong>Vallon</strong><br />
26. Huang DY, Osswald H, <strong>Vallon</strong> V. Sodium reabsorption in thick ascending limb <strong>of</strong> Henle’s<br />
loop: effect <strong>of</strong> potassium channel blockade in vivo.<br />
Br J Pharmacol, 130:1255-1262, 2000.<br />
27. Huang DY, Pfaff I, Serradeil-Le Gal C, <strong>Vallon</strong> V. Acute renal response to the non-peptide<br />
vasopressin V2-receptor antagonist SR 121463B in anesthetized rats.<br />
Naunyn-Schmiedeberg's Arch Pharmacol, 362:201-207, 2000.<br />
28. Thomson S, Bao D, Deng A, <strong>Vallon</strong> V. Adenosine formed by 5'-nucleotidase mediates<br />
tubuloglomerular feedback.<br />
J Clin Invest, 106:289-298, 2000.<br />
29. Thomson SC, Deng A, Bao D, Satriano J, Blantz RC, <strong>Vallon</strong> V. Ornithine decarboxylase,<br />
kidney size, and the tubular hypothesis <strong>of</strong> glomerular hyperfiltration in experimental<br />
diabetes.<br />
J Clin Invest, 107:217-224, 2001.<br />
30. <strong>Vallon</strong> V, Traynor T, Barajas L, Huang YG, Briggs JP, Schnermann J. Feedback control <strong>of</strong><br />
glomerular vascular tone in nNOS knockout mice.<br />
J Am Soc Nephrol, 12:1599-1606, 2001.<br />
31. <strong>Vallon</strong> V, Grahammer F, Richter K, Bleich M, Lang F, Barhanin J, Völkl H, Warth R. Role <strong>of</strong><br />
KCNE1-dependent K + fluxes in mouse proximal tubule.<br />
J Am Soc Nephrol, 12:2003-2011, 2001.<br />
32. Huang DY, Richter K, Breidenbach A, <strong>Vallon</strong> V. Human C-peptide acutely lowers<br />
glomerular hyperfiltration and proteinuria in diabetic rats: a dose-response study.<br />
Naunyn-Schmiedeberg's Arch Pharmacol, 365: 67-73, 2002.<br />
33. <strong>Vallon</strong> V, Huang DY, Deng A, Richter K, Blantz RC, Thomson SC. Salt-sensitivity <strong>of</strong><br />
proximal reabsorption alters macula densa salt and explains the paradoxical effect <strong>of</strong><br />
dietary salt on glomerular filtration rate in diabetes mellitus.<br />
J Am Soc Nephrol, 13:1865-1871, 2002.<br />
34. Pfaff IL, <strong>Vallon</strong> V. Protein kinase C beta isoenzymes in experimental diabetes mellitus and<br />
their relation to nephroprotective actions <strong>of</strong> the ACE inhibitor lisinopril.<br />
Kidney Blood Press Res, 25:329-40, 2002.<br />
35. Wulff P, <strong>Vallon</strong> V, Huang DY, Völkl H, Yu F, Richter K, Jansen M, Schlünz M, Klingel K,<br />
L<strong>of</strong>fing J, Kauselmann G, Bösl MR, Lang F, Kuhl D. Impaired renal Na + retention in the<br />
sgk1-knockout mouse.<br />
J Clin Invest, 110:1263-1268, 2002.<br />
36. Embark HM, Böhmer C, <strong>Vallon</strong> V, Luft F, Lang F. Regulation <strong>of</strong> KCNE1-dependent K +<br />
current by the serum and glucocorticoid-inducible kinase (SGK) is<strong>of</strong>orms.<br />
Eur J Physiol, 445:601-606, 2003.<br />
37. Lang UE, Lang F, Richter K, <strong>Vallon</strong> V, Lipp HP, Schnermann J, Wolfer DP. Emotional<br />
instability but intact spatial cognition in adenosine receptor 1 knock out mice.<br />
Behav Brain Res, 145:179-88, 2003.
Original publications: (continued)<br />
12<br />
V. <strong>Vallon</strong><br />
38. Birk C, Richter K, Huang DY, Piesch C, Luippold G, <strong>Vallon</strong> V. The salt paradox <strong>of</strong> the early<br />
diabetic kidney is independent <strong>of</strong> renal innervation.<br />
Kidney Blood Press Res, 26:344-350, 2003.<br />
39. Lang PA, Warskulat U, Heller-Stilb B, Huang DY, Grenz A, Myssina S, Duszenko M, Lang<br />
F, Haeussinger D, <strong>Vallon</strong> V, Wieder T. Blunted apoptosis <strong>of</strong> erythrocytes from taurine<br />
transporter deficient mice.<br />
Cell Physiol Biochem, 13:337-345, 2003.<br />
40. Hoenderop JGJ, van Leeuwen JPTM, van der Eerden BCJ, Kersten FFJ, van der Kemp<br />
AWCM, Merillat AM, Waarsing JH, Rossier BC, <strong>Vallon</strong> V, Hummler E, Bindels RJM. Renal<br />
Ca 2+ wasting, hyperabsorption and reduced bone thickness in mice lacking TRPV5.<br />
J Clin Invest, 112:1906-1914, 2003.<br />
41. <strong>Vallon</strong> V, Richter K, Huang DY, Rieg T, Schnermann J. Functional consequences at the<br />
single-nephron level <strong>of</strong> the lack <strong>of</strong> adenosine A1 receptors and tubuloglomerular feedback<br />
in mice.<br />
Eur J Physiol, 448:214-21, 2004.<br />
42. Huang DY, Wulff P, Voelkl H, L<strong>of</strong>fing J, Richter K, Kuhl D, Lang F, <strong>Vallon</strong> V. Impaired<br />
regulation <strong>of</strong> renal K + elimination in the sgk1-knockout mouse.<br />
J Am Soc Nephrol, 15:885-891, 2004.<br />
43. Redling S, Pfaff IL, Leitges M, <strong>Vallon</strong> V. Immunolocalization <strong>of</strong> protein kinase C<br />
isoenzymes alpha, beta I, beta II, delta and epsilon in mouse kidney.<br />
Am J Physiol: Renal Physiol, 287:F289-F298, 2004.<br />
44. Yao L, Huang DY, Pfaff IL, Nie X, Leitges M, <strong>Vallon</strong> V. Evidence for a role <strong>of</strong> protein kinase<br />
C alpha in urine concentration.<br />
Am J Physiol: Renal Physiol, 287:F299-F304, 2004.<br />
45. L<strong>of</strong>fing J, <strong>Vallon</strong> V, L<strong>of</strong>fing-Cueni D, Aregger F, Richter K, Pietri L, Bloch-Faure M,<br />
Hoenderop JGJ, Shull GE, Meneton P, Kaissling B. Altered renal distal tubule structure and<br />
renal Na + and Ca 2+ handling in a mouse model for Gitelman’s syndrome.<br />
J Am Soc Nephrol, 15:2276-2288, 2004.<br />
46. Rieg T, Richter K, Osswald H, <strong>Vallon</strong> V. Kidney function in mice: thiobutabarbital versus<br />
alpha-chloralose anesthesia.<br />
Naunyn-Schmiedeberg's Arch Pharmacol, 370: 320-323, 2004.<br />
47. Rieg T, Steigele H, Schnermann J, Richter K, Osswald H, <strong>Vallon</strong> V. Requirement <strong>of</strong> intact<br />
adenosine A1 receptors for the diuretic and natriuretic action <strong>of</strong> the methylxanthines<br />
theophylline and caffeine.<br />
J Pharmacol Exp Ther, 313: 403-409, 2005.<br />
48. <strong>Vallon</strong> V, Huang DY, Grahammer F, Wyatt AW, Osswald H, Wulff P, Kuhl D, Lang F. SGK1 as<br />
a determinant <strong>of</strong> kidney function and salt intake in response to mineralocorticoid excess.<br />
Am J Physiol: Regul Integr Comp Physiol, 289:R395-R401, 2005.<br />
49. Nijenhuis T, <strong>Vallon</strong> V, van der Kemp AWCM, L<strong>of</strong>fing J, Hoenderop JGJ, Bindels RJM.<br />
Enhanced passive Ca 2+ reabsorption and reduced Mg 2+ channel abundance explains thiazideinduced<br />
hypocalciuria and hypomagnesemia.<br />
J Clin Invest, 115:1651-1658, 2005.
Original publications: (continued)<br />
13<br />
V. <strong>Vallon</strong><br />
50. Nie X, Arrighi I, Kaissling B, Pfaff I, Mann J, Barhanin J, <strong>Vallon</strong> V. Expression and insights on<br />
function <strong>of</strong> potassium channel TWIK-1 in mouse kidney.<br />
Europ J Physiol, 451:479-88, 2005.<br />
51. <strong>Vallon</strong> V, Grahammer F, Volkl H, <strong>San</strong>du CD, Richter K, Rexhepaj R, Gerlach U, Rong Q,<br />
Pfeifer K, Lang F. KCNQ1 dependent transport in renal and gastrointestinal epithelia.<br />
Proc Natl Acad Sci U S A, 102:17864-17869, 2005.<br />
52. Huang DY, Boini K, Lang P, Grahammer F, Duszenko M, Heller-Stilb B, Warskulat U,<br />
Häussinger D, Lang F, <strong>Vallon</strong> V. Impaired ability to increase water excretion in mice lacking the<br />
taurine transporter gene TAUT<br />
Europ J Physiol, 451: 668-677, 2006.<br />
53. Wyatt AW, Hussain A, Amann K, Klingel K, Kandolf R, Artunc F, Grahammer F, Huang DY,<br />
<strong>Vallon</strong> V, Kuhl D, Lang F. DOCA-induced phosphorylation <strong>of</strong> glycogen synthase kinase 3 beta.<br />
Cell Physiol Biochem. 17:137-44, 2006.<br />
54. <strong>San</strong>dulache D, Grahammer F, Artunc F, Henke G, Hussain A, Nasir O, Mack A, Friedrich B,<br />
<strong>Vallon</strong> V, Wulff P, Kuhl D, Palmada M, Lang F. Renal Ca 2+ handling in sgk1-knockout mice.<br />
Europ J Physiol, 452:444-52, 2006.<br />
55. <strong>Vallon</strong> V, Wyatt AW, Klingel K, Huang DY, Hussain A, Berchtold S, Friedrich B, Grahammer F,<br />
BelAiba RS, Görlach A, Wulff P, Daut J, Dalton ND, Ross J Jr, Osswald H, Kandolf R, Kuhl D,<br />
Lang F. SGK1-dependent cardiac CTGF formation and fibrosis following DOCA treatment.<br />
J Mol Med, 84:396-404, 2006.<br />
56. Huang DY, Boini KM, Friedrich B, Metzger M, Just L, Osswald H, Wulff P, Kuhl D, <strong>Vallon</strong> V,<br />
Lang V. Blunted hypertensive effect <strong>of</strong> combined fructose and high salt diet in gene targeted<br />
mice lacking functional serum and glucocorticoid inducible kinase sgk1.<br />
Am J Physiol: Regul Integr Comp Physiol, 290: R935-R944, 2006.<br />
57. Yao L-J, Leitges M, <strong>Vallon</strong> V. Mice lacking protein kinase C beta present modest increases in<br />
systolic blood pressure and NH4Cl-induced metabolic acidosis.<br />
Kidney Blood Press Res, 29:36-42, 2006.<br />
58. Eraly SA, <strong>Vallon</strong> V, Vaughn DA, Gangoiti JA, Richter K, Nagle M, Monte JC, Rieg T, Truong<br />
DM, Long JM, Barshop BA, Kaler G, Nigam SK. Decreased renal organic anion secretion and<br />
plasma accumulation <strong>of</strong> endogenous organic anions in OAT1 knockout mice.<br />
J Biol Chem, 281: 5072-5083, 2006.<br />
59. Thomson SC, Deng A, Wead L, Richter K, Blantz RC, <strong>Vallon</strong> V. An unexpected role for<br />
angiotensin II in the link between dietary salt and proximal reabsorption.<br />
J Clin Invest, 116:1110-6, 2006.<br />
60. Huang DY, <strong>Vallon</strong> V, Zimmermann H, Koszalka P, Schrader J, Osswald H. Ecto-5’nucleotidase<br />
(cd73)-dependent and -independent generation <strong>of</strong> adenosine participates in the<br />
mediation <strong>of</strong> tubuloglomerular feedback in vivo.<br />
Am J Physiol Renal Physiol, 291:F282-F288, 2006.
Original publications: (continued)<br />
14<br />
V. <strong>Vallon</strong><br />
61. Boini KM, Hennige AM, Huang DY, Friedrich B, Palmada M, Boehmer C, Grahammer F, Artunc<br />
F, Ullrich S, Avram D, Osswald H, Wulff P, Kuhl D, <strong>Vallon</strong> V, Häring HU, Lang F. The serum<br />
and glucocorticoid inducible kinase SGK1 mediates salt sensitivity <strong>of</strong> glucose tolerance.<br />
Diabetes, 55:2059-2066, 2006.<br />
62. Artunc F, Amann K, Nasir O, Friedrich B, <strong>San</strong>dulache D, Jahovic N, Risler T, <strong>Vallon</strong> V, Wulff P,<br />
Kuhl D, Lang F. Blunted DOCA/high salt induced albuminuria and renal tubulointerstitial<br />
damage in gene-targeted mice lacking SGK1.<br />
J Mol Medicine, 84:737-46, 2006.<br />
63. Huang DY, Boini KM, Osswald H, Friedrich B, Artunc F, Ullrich S, Jeyaganesh R, Palmada M,<br />
Wulff P, Kuhl D, <strong>Vallon</strong> V and Lang F. Resistance <strong>of</strong> mice lacking the serum and glucocorticoid<br />
inducible kinase sgk1 against salt-sensitive hypertension induced by high fat diet.<br />
Am J Physiol Renal Physiol, 291:F1264-F1273, 2006.<br />
64. Rieg T, Schnermann J, <strong>Vallon</strong> V. Adenosine A1 receptors determine effects <strong>of</strong> caffeine on total<br />
fluid intake but not caffeine appetite.<br />
Eur J Pharmacol, 555:174-177, 2007.<br />
65. Zhang W, Xia, X, Reisenauer MR, Rieg T, Lang F, Kuhl D, <strong>Vallon</strong> V, Kone B. Aldosteroneinduced<br />
SGK1 phosphorylates AF9 and relieves Dot1a-AF9-mediated transcriptional<br />
repression <strong>of</strong> ENaC�.<br />
J Clin Invest, 117:773-783, 2007.<br />
66. Rieg T, <strong>Vallon</strong> V, Sausbier M, Sausbier U, Kaissling B, Ruth P, Osswald H. A role <strong>of</strong> BK<br />
channel in K + homeostasis and flow-induced renal K + excretion.<br />
Kidney Int, 72:566-573, 2007.<br />
67. Rieg T, Bundey RA, Chen Y, Deschenes G, Junger W, Insel PA, <strong>Vallon</strong> V. Mice lacking P2Y2<br />
receptors have salt-resistant hypertension and facilitated renal Na + and water reabsorption.<br />
FASEB J, 21:3717-26, 2007.<br />
68. Miracle CM, Rieg T, Blantz RC, <strong>Vallon</strong> V, Thomson SC. Combined effects <strong>of</strong> carbonic<br />
anhydrase inhibitor and adenosine A1 receptor antagonist on hemodynamic and tubular<br />
function in the kidney.<br />
Kidney Blood Press Res, 30:388-399, 2007.<br />
69. Grenz A, Zhang H, Weingart J, von Wietersheim S, Eckle T, Schnermann JB, Kohle C, Kloor<br />
D, Gleiter CH, <strong>Vallon</strong> V, Eltzschig HK, Osswald H. Lack <strong>of</strong> effect <strong>of</strong> extracellular adenosine<br />
generation and signalling on renal erythropoietin secretion during hypoxia.<br />
Am J Physiol Renal Physiol, 293:F1501-F1511, 2007.<br />
70. Laske-Ernst J, Stehle A, <strong>Vallon</strong> V, Quast U, Russ U. Effect <strong>of</strong> adenosine on membrane<br />
potential and Ca 2+ in juxtaglomerular cells: Comparison with angiotensin II.<br />
Kidney Blood Press Res, 31:94-103, 2008.<br />
71. Rieg T, Pothula K, Schroth J, Satriano J, Osswald H, Schnermann J, Insel PA, Bundey RA,<br />
<strong>Vallon</strong> V. Vasopressin regulation <strong>of</strong> inner medullary collecting ducts and compensatory<br />
changes in mice lacking adenosine A1 receptors.<br />
Am J Physiol Renal Physiol, 294:F638-F644, 2008.
Original publications: (continued)<br />
72. <strong>Vallon</strong> V, Rieg T, Ahn SY, Wu W, Eraly SA, Nigam SK. Overlapping in vitro and in vivo<br />
specificities <strong>of</strong> the organic anion transporters OAT1 and OAT3 for loop and thiazide<br />
diuretics.<br />
Am J Physiol Renal Physiol, 294: F867-F873, 2008.<br />
15<br />
V. <strong>Vallon</strong><br />
73. Eraly SA, <strong>Vallon</strong> V, Rieg T, Gangoiti JA, Wik<strong>of</strong>f WR, Siuzdak G, Barshop BA, Nigam SK.<br />
Multiple organic anion transporters contribute to net renal excretion <strong>of</strong> uric acid.<br />
Physiological Genomics, 33:180-192, 2008.<br />
74. <strong>Vallon</strong> V, Eraly SA, Wik<strong>of</strong>f WR, Rieg T, Kaler G, Truong DM, Ahn SY, Mahapatra NR,<br />
Mahata SK, Gangoiti JA, Wu W, Barshop BA, Siuzdak G, and Nigam SK. Organic anion<br />
transporter 3 contributes to the regulation <strong>of</strong> blood pressure.<br />
J Am Soc Nephrol, 19:1732-1740, 2008.<br />
75. Miracle CM, Rieg T, Mansoury HA, <strong>Vallon</strong> V, Thomson SC. Ornithine decarboxylase<br />
inhibitor eliminates hyper-responsiveness <strong>of</strong> the early diabetic proximal tubule to dietary<br />
salt.<br />
Am J Physiol Renal Physiol, 295:F995-F1002, 2008.<br />
76. Pochynyuk O, Bugaj V, Rieg T, Insel PA, Mironova E, <strong>Vallon</strong> V, Stockand JD. Paracrine<br />
regulation <strong>of</strong> the epithelial Na + channel in the mammalian collecting duct by purinergic<br />
P2Y2 receptor tone.<br />
J Biol Chem, 283:36599-607, 2008.<br />
77. <strong>Vallon</strong> V, Hummler E, Rieg T, Pochynyuk O, Bugaj V, Schroth J, Dechenes G, Rossier B,<br />
Cunard R, and Stockand J. Thiazolidinedione-induced fluid retention is independent <strong>of</strong><br />
collecting duct �ENaC activity.<br />
J Am Soc Nephrol, 20:721-729, 2009.<br />
78. <strong>Vallon</strong> V, Schroth J, Satriano J, Blantz RC, Thomson S, Rieg T. Adenosine A1 receptors<br />
determine glomerular hyperfiltration and the salt paradox in early diabetes mellitus.<br />
Nephron Physiol, 111:30-38, 2009.<br />
79. Ackermann T, Boini K, Volkl H, Bhandaru M, Bareiss P, Just L, <strong>Vallon</strong> V, Amann K, Kuhl D,<br />
Feng Y, Hammes HP, Lang F. SGK1-sensitive renal tubular glucose reabsorption in<br />
diabetes.<br />
Am J Physiol Renal Physiol, 296:F859-F866, 2009.<br />
80. Boini KM, Graf D, Hennige AM, Koka S, Kempe DS, Wang K, Ackermann TF, Föller M,<br />
<strong>Vallon</strong> V, Pfeifer K, Schleicher E, Ullrich S, Häring HU, Häussinger D, Lang F. Enhanced<br />
insulin sensitivity <strong>of</strong> gene targeted mice lacking functional KCNQ1. Am J Physiol: Regul<br />
Integr Comp Physiol, 296:R1695-R1701, 2009.<br />
81. Wu W, Kitamura S, Truong DM, Rieg T, <strong>Vallon</strong> V, Sakurai H, Bush KT, Vera D, Ross RS,<br />
Nigam SK. �1 integrin is reqired for kidney collecting duct morphogenesis and<br />
maintenance <strong>of</strong> renal function. Am J Physiol Renal Physiol, 297:F210-F217, 2009.<br />
82. <strong>Vallon</strong> V, Schroth J, Lang F, Kuhl D, Uchida S. Expression and phosphorylation <strong>of</strong> the<br />
NaCl-cotransporter NCC in vivo is regulated by dietary salt, potassium and SGK1. Am J<br />
Physiol Renal Physiol, 297:F704-F712, 2009.
Original publications: (continued)<br />
16<br />
V. <strong>Vallon</strong><br />
83. Pochynyuk O, Rieg T, Bugaj V, Schroth J, Fridman A, Boss GR, Insel PA, Stockand JD,<br />
<strong>Vallon</strong> V. Dietary Na + inhibits the open probability <strong>of</strong> the epithelial sodium channel in the<br />
kidney by enhancing apical P2Y2 receptor tone. FASEB J, 24:2056-65, 2010.<br />
84. Satriano J, Mansoury H, Deng A, Sharma K, <strong>Vallon</strong> V, Blantz RC, and Thomson SC.<br />
Transition <strong>of</strong> kidney tubule cells to a senescent phenotype in early experimental diabetes.<br />
Am J Physiol Cell Physiol, in press, 2010.<br />
85. <strong>Vallon</strong> V, Platt KA, Cunard R, Schroth J, Whaley J, Thomson SC, Koepsell H, Rieg T. Lack<br />
<strong>of</strong> early proximal tubular glucose reabsorption in transgenic Sglt2 null mice. J Am Soc<br />
Nephrol, in press, 2010.<br />
86. Stockand JD, Mironova, Bugaj V, Rieg T, Insel PA, <strong>Vallon</strong> V, Peti-Peterdi J, Pochynyuk O.<br />
Purinergic inhibition <strong>of</strong> ENaC produces aldosterone escape. J Am Soc Nephrol, in press,<br />
2010.<br />
Original publications without “peer review”:<br />
1. <strong>Vallon</strong> V, Chen M, Yang T, Briggs J, Schnermann J. Molecular and functional evidence for<br />
expression <strong>of</strong> adenosine receptors in zebrafish, Danio rerio.<br />
Mt Des Island Biol L 39:33-34, 2000.<br />
2. Chen M, <strong>Vallon</strong> V, Smart A, Endo Y, Schnermann J, Briggs JP. Studies <strong>of</strong> the zebrafish<br />
(Danio rerio) renin-angiotensin system.<br />
Mt Des Island Biol L 39: 35-36, 2000.<br />
3. Endo Y, Chen M, <strong>Vallon</strong> V, Schnermann J, Briggs JP. Expression <strong>of</strong> cathepsin D and<br />
angiotensinogen in nephrons <strong>of</strong> zebrafish kidney.<br />
Mt Des Island Biol L 39:31-32, 2000.<br />
Identification and Sequencing <strong>of</strong> Genes:<br />
1. DEFINITION: Danio rerio cathepsin D precursor (catD) mRNA, complete cds.<br />
ACCESSION: AY050516<br />
AUTHORS: Chen M, <strong>Vallon</strong> V, Smart J, Smart A, Endo Y, Schnermann JB, Briggs JP<br />
TITLE: Cathepsin D is Responsible for Angiotensin Generation in Zebrafish<br />
JOURNAL: Unpublished<br />
2. DEFINITION: Danio rerio angiotensinogen precursor, mRNA, complete cds.<br />
ACCESSION: AY049731<br />
AUTHORS: Chen M, <strong>Vallon</strong> V, Schnermann JB, Endo Y, Smart J, Smart A, Briggs JP<br />
TITLE: Cathepsin D is responsible for angiotensin generation in zebrafish<br />
JOURNAL: Unpublished
Reviews/Commentaries:<br />
17<br />
V. <strong>Vallon</strong><br />
1. Blantz RC, Lortie M, <strong>Vallon</strong> V, Gabbai F, Parmer R, Thomson S. Activities <strong>of</strong> nitric oxide in<br />
normal physiology and uremia.<br />
Seminars in <strong>Nephrology</strong>, 16:144-150, 1996.<br />
2. Osswald H, <strong>Vallon</strong> V, Mühlbauer M. Role <strong>of</strong> adenosine in tubuloglomerular feedback and<br />
acute renal failure.<br />
J Autonom Pharmacol, 16:377-380, 1996.<br />
3. Osswald H, Mühlbauer M, <strong>Vallon</strong> V. Adenosine and tubuloglomerular feedback.<br />
Blood Purif 15:243-252, 1997.<br />
4. Thomson SC, <strong>Vallon</strong> V, Blantz RC. Resetting protects efficiency <strong>of</strong> tubuloglomerular<br />
feedback.<br />
Kidney Int, Suppl. 67:S65-S70, 1998.<br />
5. <strong>Vallon</strong> V, Osswald H, Blantz RC, Thomson SC. Luminal signal in tubuloglomerular<br />
feedback: What about potassium?<br />
Kidney Int, Suppl. 67:S177-S179, 1998.<br />
6. Blantz RC, Deng A, Lortie M, Munger K, <strong>Vallon</strong> V, Gabbai FB, Thomson SC. The complex<br />
role <strong>of</strong> nitric oxide in the regulation <strong>of</strong> glomerular ultrafiltration.<br />
Kidney Int 61:782-785, 2002.<br />
7. <strong>Vallon</strong> V. Tubuloglomerular feedback in the kidney: insights from gene-targeted mice.<br />
Eur J Physiol 445:470-476, 2003.<br />
8. <strong>Vallon</strong> V, Blantz RC, Thomson SC. Glomerular hyperfiltration and the salt paradox in early<br />
diabetes mellitus: a tubulo-centric view.<br />
J Am Soc Nephrol 14:530-537, 2003.<br />
9. Lang F, Henke G, Embark H, Waldegger S, Palmada M, Böhmer C, <strong>Vallon</strong> V. Regulation<br />
<strong>of</strong> channels by the serum and glucocorticoid-inducible kinase: implication for transport,<br />
excitability and cell proliferation.<br />
Cell Physiol Biochem 13:41-50, 2003.<br />
10. <strong>Vallon</strong> V. In vivo studies <strong>of</strong> the genetically modified mouse kidney.<br />
Nephron Physiol 94:P1-5, 2003.<br />
11. <strong>Vallon</strong> V. Tubuloglomerular feedback and the control <strong>of</strong> glomerular filtration rate.<br />
News Physiol Sci 18:169-74, 2003.<br />
12. Thomson SC, <strong>Vallon</strong> V, Blantz RC. Kidney function in early diabetes: the tubular hypothesis<br />
<strong>of</strong> glomerular filtration.<br />
Am J Physiol: Renal Physiol 286:F8-F15, 2004.<br />
13. <strong>Vallon</strong> V, Wulff P, Huang D, L<strong>of</strong>fing J, Voelkl H, Kuhl D, Lang F. Role <strong>of</strong> sgk1 in salt and<br />
potassium homeostasis.<br />
Am J Physiol: Regul Integr Comp Physiol 288: R4-R10, 2005.
Reviews/Commentaries: (continued)<br />
18<br />
V. <strong>Vallon</strong><br />
14. Lang F, <strong>Vallon</strong> V, Grahammer F, Böhmer C, Palmada M. Transport regulation by the serum<br />
and glucocorticoid inducible kinase SGK1.<br />
Biochem Soc Transactions, 33:213-5, 2005.<br />
15. <strong>Vallon</strong> V, Lang F. New insights into the role <strong>of</strong> serum- and glucocorticoid-inducible kinase<br />
SGK1 in the regulation <strong>of</strong> renal function and blood pressure.<br />
Curr Opin Nephrol Hypertens, 14:59-66, 2005.<br />
16. <strong>Vallon</strong> V, Blantz RC, Thomson S. The salt paradox and its possible implications in<br />
managing hypertensive diabetic patients.<br />
Current <strong>Hypertension</strong> Reports, 7:141-7, 2005.<br />
17. Hummler E, <strong>Vallon</strong> V. Lessons from mouse mutants <strong>of</strong> ENaC and its regulatory proteins.<br />
J Am Soc Nephrol, 16:3160-3166, 2005.<br />
18. Satriano J, <strong>Vallon</strong> V. Primary kidney growth and its consequences at the onset <strong>of</strong> diabetes<br />
mellitus.<br />
Amino Acids, 31:1-9, 2006.<br />
19. <strong>Vallon</strong> V, Muhlbauer B, Osswald H. Adenosine and kidney function.<br />
Physiol Rev, 86:901-40, 2006.<br />
20. Lang F, Böhmer C, Palmada M, Seebohm G, Strutz-Seebohm N, <strong>Vallon</strong> V.<br />
(Patho)physiological significance <strong>of</strong> the serum- and glucocorticoid-inducible kinase<br />
is<strong>of</strong>orms.<br />
Physiol Rev, 86:1151-1178, 2006.<br />
21. Blantz RC, <strong>Vallon</strong> V. Tubuloglomerular feedback responses <strong>of</strong> the downstream efferent<br />
resistance: unmasking a role for adenosine?<br />
Kidney Int, 71:837-839, 2007.<br />
22. Lang F, <strong>Vallon</strong> V, Knipper M, Wangemann P. Functional significance <strong>of</strong> channels<br />
expressed in the inner ear and the kidney.<br />
Am J Physiol Cell Physiol, 293:C1187-2, 2007.<br />
23. <strong>Vallon</strong> V. P2 receptors in the regulation <strong>of</strong> renal transport mechanisms.<br />
Am J Physiol Renal Physiol, 294:F10-27, 2008.<br />
24. <strong>Vallon</strong> V, Miracle C, Thomson S. Adenosine and kidney function: potential implications in<br />
the patients with heart failure.<br />
Eur J Heart Failure, 10:176-87, 2008.<br />
25. <strong>Vallon</strong> V. Regulation <strong>of</strong> the Na-Cl cotransporter NCC by dietary NaCl: a role for WNKs,<br />
SPAK, OSR1, and aldosterone.<br />
Kidney Int, 74:1373-1375, 2008.<br />
26. <strong>Vallon</strong> V. Techniques to study nephron function: Micropuncturing the Nephron.<br />
In “A Molecular Guided Tour Along the Nephron”.<br />
Eur J Physiology, 458:189–201, 2009.<br />
27. Rieg T, <strong>Vallon</strong> V. ATP and adenosine in the local regulation <strong>of</strong> water transport and<br />
homeostasis by the kidney.<br />
Am J Physiol: Regul Integr Comp Physiol, 296:R419-R427, 2009.
Reviews/Commentaries: (continued)<br />
28. Lang F, Artunc F, <strong>Vallon</strong> V. The physiological impact <strong>of</strong> the serum- and glucocorticoidinducible<br />
kinase SGK1.<br />
Current Opinion in <strong>Nephrology</strong> and <strong>Hypertension</strong>, 18:439-448, 2009.<br />
29. Lang F, Görlach A, <strong>Vallon</strong> V. Targeting SGK1 in diabetes.<br />
Expert Opin Ther Targets, 13:1303-11, 2009.<br />
19<br />
V. <strong>Vallon</strong><br />
30. <strong>Vallon</strong> V, Sharma K. Sodium-glucose transport: role in diabetes mellitus and potential clinical<br />
implications.<br />
Current Opinion in <strong>Nephrology</strong> and <strong>Hypertension</strong>, accepted, 2010<br />
Book chapters and Books:<br />
1. Osswald H, <strong>Vallon</strong> V. Tubuloglomerular feedback and its role in acute renal failure.<br />
In: Critical Care <strong>Nephrology</strong>, C. Ronco and R. Bellomo, editors; Kluwer academic<br />
publishers, pp 613-622, 1998.<br />
2. <strong>Vallon</strong> V, Schnermann J. Tubuloglomerular feedback.<br />
In: Methods in Molecular Medicine: Renal Disease. Guide to Technical Approaches. M.S.<br />
Goligorski, editor; Humana Press Inc. Totowa, New Jersey.<br />
Methods Mol Med 86:429-441, 2003.<br />
3. Osswald H, <strong>Vallon</strong> V, Luippold G, Gleiter C. Diuretika.<br />
Wissenschaftliche Verlagsgesellschaft mbH, Stuttgart, 2004.<br />
4. Osswald H, <strong>Vallon</strong> V. Adenosine and tubuloglomerular feedback in the pathophysiology <strong>of</strong><br />
acute renal failure. In: Critical Care <strong>Nephrology</strong>, C. Ronco, R. Bellomo, J.A. Kellum, editors;<br />
Saunders Elsevier, Philadelphia, pp128-134, 2009.<br />
5. <strong>Vallon</strong> V, Osswald H. Adenosine receptors and the kidney.<br />
In: Handbook <strong>of</strong> Experimental Pharmacology 193: Adenosine Receptors in Health and<br />
Disease, C.N. Wilson and S.J. Mustafa (eds.), DOI 10.1007/978-3-540-89615-9 15,<br />
Springer-Verlag Berlin Heidelberg, pp 443-470, 2009.
TEACHING ACTIVITIES<br />
20<br />
V. <strong>Vallon</strong><br />
Teaching constitutes an important aspect <strong>of</strong> my academic activities. Therefore, in 2002/2003 I<br />
completed the course „Academic Teaching in Medicine“ (Zertifikat Hochschullehre Medizin, Baden<br />
Wuerttemberg, Germany), which was provided by the Center <strong>of</strong> Academic Didactics <strong>of</strong> Medicine<br />
(Medical Faculties <strong>of</strong> the Universities <strong>of</strong> Tübingen, Freiburg and Ulm). This course comprises a total<br />
<strong>of</strong> 200 hours (each hour 45 min) and includes problem-based learning, microteaching and vide<strong>of</strong>eedback<br />
as well as integrated coaching sessions with colleagues, which help to reflect and<br />
improve the personal teaching technic. Central aspects <strong>of</strong> my teaching philosophy include: a) to aim<br />
for an integrative understanding <strong>of</strong> medicine (from physiology to pathophysiology to<br />
pharmacotherapy), which is required for the future physicians to appropriately respond to the<br />
individual and complex problems <strong>of</strong> a given patient, and b) to stress the active participation <strong>of</strong><br />
students in teaching activities. The positive evaluations <strong>of</strong> my teaching activities indicate to me that<br />
the students are receptive to this approach.<br />
A) University <strong>of</strong> Tübingen<br />
ST: summer term; WT: winter term<br />
Course <strong>of</strong> General and Systematic Pharmacology and Toxicology for Medical Students (3. year)<br />
- coronary artery disease and heart failure<br />
- diuretics and antihypertensives<br />
18 hours per term: ST 1992 - ST 1993, WT 1995/96 to ST 2003<br />
Course <strong>of</strong> Clinical Pharmacology for Medical Students (5. year):<br />
- basics <strong>of</strong> pharmacotherapy<br />
- heart failure<br />
- coronary artery disease<br />
- arterial hypertension and hypotension<br />
- diseases <strong>of</strong> the lungs<br />
- diseases <strong>of</strong> the gastrointestinal tract<br />
- psychological diseases<br />
- diabetes mellitus<br />
- pain therapy<br />
18 hours per term: ST 1997 to ST 2003<br />
Lecture on Pharmacology for Dental Medicine Students (4. year):<br />
- cardiovascular diseases<br />
- gastrointestinal tract diseases<br />
3 hours per term: ST 2002 to ST 2003<br />
Curriculum Kidney for Medical Students (together with physicians <strong>of</strong> Internal Medicine) (3. year):<br />
- acute renal failure<br />
- water and electrolyte balance<br />
1 hour per term: ST 2000 to ST 2003<br />
Clinical Pharmacology at the Bedside for Medical Students (5. year):<br />
2 hours per term: ST 2002
TEACHING ACTIVITIES (continued)<br />
21<br />
V. <strong>Vallon</strong><br />
Course <strong>of</strong> Pharmacology for Biology Students (4. year):<br />
- physiology and pharmacology <strong>of</strong> glomerular hemodynamics and transport processes in the<br />
kidney: principles <strong>of</strong> diuretic actions.<br />
8 hours per term: ST 1993, ST 1997, WT 1997/98, WT 1998/99, ST 2000 to 2003.<br />
B) University <strong>of</strong> California <strong>San</strong> Diego<br />
Department <strong>of</strong> Pharmacology<br />
“Principles <strong>of</strong> Pharmacology” for Medical Students (1. Year):<br />
- pharmacokinetic workshop<br />
- autonomic pharmacology workshop<br />
- vasodilator workshop<br />
6 hours per year: since 2003/04.<br />
Department <strong>of</strong> Pharmacy<br />
“Contemporary Topics in Pharmacology” for Pharmacy Students (3. Year):<br />
- hyperlipoproteinemia<br />
- fluid retention/edema<br />
- heart failure<br />
8 hours per year: since 2004/05.<br />
Department <strong>of</strong> Bioengineering<br />
“Renal Physiology” for Bioengineering Students:<br />
- genetic manipulations to reveal physiological functions<br />
1 hour per year: 2006/07, 2007/08.<br />
Department <strong>of</strong> Medicine<br />
“Renal Organ Physiology” for Medical and Pharmacy Students:<br />
Case discussions<br />
4 hours per year: since 2007/08.<br />
Biomedicine / Pharmacy<br />
“Drugs and Disease” for Graduate Students:<br />
Lecture<br />
2 hours per year: since 2008/09
ADVISER AND MENTORING OF MD AND PhD THESES<br />
Ph.D. Thesis:<br />
- Imke Pfaff (1994)<br />
- Dan-Yang Huang (1996)<br />
- Xin Nie (1997)<br />
- Lijun Yao (1999)<br />
M.D. Thesis:<br />
- Dorothee Kirschenmann (2000)<br />
- Ines Brenner (2000)<br />
- Doreen Blach (2001)<br />
- Kathrin Pangidis (2003)<br />
- Stephanie Redling (2003)<br />
- Claudia Birk (2005)<br />
MENTORING OF POST-DOCS<br />
- Dan-Yang Huang, Ph.D. (1996-2003)<br />
(received independent funding in 2004 from German Research Association)<br />
22<br />
V. <strong>Vallon</strong><br />
- Timo Rieg, MD (since 2003)<br />
(received fellowship from German Research Association 2004-2007; received fellowship from<br />
National Kidney Foundation 2008-2009; winner <strong>of</strong> the DSI-sponsored Trainee Award <strong>of</strong> the<br />
Water and Electrolyte Homeostasis Section, American Physiological Society 2008; Renal<br />
Research Recognition Award, Renal Section, American Physisology Society 2009; Scientist<br />
Development Grant, AHA 2010; Assistant Pr<strong>of</strong>essor, <strong>UC</strong> <strong>San</strong> Diego, 2010)
SCIENTIFIC SEMINARS AND ORAL PRESENTATIONS:<br />
23<br />
V. <strong>Vallon</strong><br />
1. <strong>Vallon</strong> V, Osswald H. Early changes <strong>of</strong> kidney function in streptozotocin (STZ)-diabetes in<br />
rats: effect <strong>of</strong> dipyridamole.<br />
34 th Spring Meeting German Society <strong>of</strong> Pharmacology and Toxicology, Mainz, 3/1993.<br />
2. <strong>Vallon</strong> V. Effect <strong>of</strong> dipyridamole on kidney function in experimental diabetes mellitus.<br />
Seminar (Host: Pr<strong>of</strong>. Dr. med. Teut Risler), Department <strong>of</strong> Medicine, University <strong>of</strong><br />
Tübingen, 4/1993.<br />
3. <strong>Vallon</strong> V, Meyer J, Schenk F, Osswald H. Reduced activity <strong>of</strong> tubuloglomerular feedback in<br />
diabetic rats and its normalization by dipyridamole.<br />
XII Int. Congress <strong>of</strong> <strong>Nephrology</strong>, Jerusalem, Israel, 6/1993.<br />
4. <strong>Vallon</strong> V, Thomson S, Peterson OW, Gabbai FB, Blantz RC. Interactive control <strong>of</strong> renal<br />
function by α2-adrenergic system and nitric oxide: role <strong>of</strong> angiotensin II.<br />
Clinical Research Meeting, American Society for Clinical Investigation, Baltimore, MD,<br />
4/1994.<br />
5. <strong>Vallon</strong> V, Blantz RC, Thomson S. Increased tubular flow induces resetting <strong>of</strong><br />
tubuloglomerular feedback.<br />
Annual Meeting, West Coast Salt and Water Club, Morro Bay, CA, 3/1995.<br />
6. <strong>Vallon</strong> V. Pathophysiology <strong>of</strong> kidney function in experimental diabetes mellitus. <strong>Nephrology</strong><br />
Seminar (Hosts: Roland C. Blantz, M.D., Dan O‘Connor, M.D.), <strong>Division</strong> <strong>of</strong> <strong>Nephrology</strong>-<br />
<strong>Hypertension</strong>, Department <strong>of</strong> Medicine, University <strong>of</strong> California <strong>San</strong> Diego, 5/1995.<br />
7. <strong>Vallon</strong> V. Studies on tubuloglomerular feedback in experimental diabetes mellitus.<br />
Seminar on Kidney Disease and <strong>Hypertension</strong> (Host: Pr<strong>of</strong>. Dr. med. Rahn), Department <strong>of</strong><br />
Medicine, University <strong>of</strong> Münster, 9/1995.<br />
8. <strong>Vallon</strong> V, Heyne N, Osswald H. Intratubular angiotensin 1-7 does not affect<br />
tubuloglomerular feedback.<br />
37th Spring Meeting German Society <strong>of</strong> Pharmacology and Toxicology, Mainz, 1996.<br />
9. <strong>Vallon</strong> V, Osswald H, Thomson S. Blockade <strong>of</strong> ATP-sensitive potassium channels inhibits<br />
tubuloglomerular feedback.<br />
27. Annual Meeting German Society <strong>of</strong> <strong>Nephrology</strong>, Berlin, 1996.<br />
10. <strong>Vallon</strong> V, Osswald H, Thomson S. Studying the role <strong>of</strong> intratubular potassium in<br />
tubuloglomerular feedback by using K channel blocker U37883A.<br />
38th Spring Meeting German Society <strong>of</strong> Pharmacology and Toxicology, Mainz, 1997.<br />
11. <strong>Vallon</strong> V. New aspects on the physiology <strong>of</strong> the tubuloglomerular feedback.<br />
Seminar (Host: Pr<strong>of</strong>. Dr. med. Dieter Häberle), Department <strong>of</strong> Physiology, Maximillian<br />
University Munich, 3/1997.<br />
12. <strong>Vallon</strong> V. Tubuloglomerular feedback in experimental diabetes mellitus.<br />
Annual Meeting Vascular Disease Section Tübingen, Blaubeuren, 5/1997.<br />
13. <strong>Vallon</strong> V. Pathophysiology <strong>of</strong> glomerular hyperfiltration in experimental diabetes mellitus.<br />
Seminar Kidney Disease and <strong>Hypertension</strong> (Host: Pr<strong>of</strong>. Dr. rer. nat. Sebastian Bachmann),<br />
University Clinic Charité, Medical Faculty Humboldt-University, Berlin, 7/1997.
SEMINARS AND ORAL PRESENTATIONS: (continued)<br />
14. <strong>Vallon</strong> V. Salt diet and kidney function in experimental diabetes mellitus.<br />
1. Symposium <strong>of</strong> the Interdisciplinary Clinical Research Center Tübingen, Blaubeuren,<br />
11/1997.<br />
24<br />
V. <strong>Vallon</strong><br />
15. <strong>Vallon</strong> V. Tubuloglomerular feedback in diabetes mellitus.<br />
FASEB Summer Research Conference on Renal hemodynamics (Hosts: John Hall, M.D.,<br />
Jürgen Schnermann, M.D.), Saxton River, VT, 6/1998.<br />
16. <strong>Vallon</strong> V, Richter K. Glomerular hyperfiltration in experimental diabetes mellitus: Potential<br />
role <strong>of</strong> tubular reabsorption.<br />
29. Annual Meeting German Society <strong>of</strong> <strong>Nephrology</strong>, Erlangen, 1998.<br />
17. <strong>Vallon</strong> V. Control <strong>of</strong> glomerular filtration rate in experimental diabetes mellitus.<br />
Joint Meeting <strong>of</strong> the German Society for Clinical Microcirculation and Hemorheology and<br />
Vascular Disease SectionTübingen, Tübingen, 9/1998.<br />
18. <strong>Vallon</strong> V. Tubuloglomerular feedback: pathophysiological role in glomerular hyp<strong>of</strong>iltration<br />
and hyperfiltration.<br />
Seminar (Host: Pr<strong>of</strong>. Dr. med. Michael Schwarz), Department <strong>of</strong> Toxicology, University <strong>of</strong><br />
Tübingen, 10/1998.<br />
19. <strong>Vallon</strong> V. Control <strong>of</strong> kidney function by tubuloglomerular feedback: studies on the luminal<br />
signal and the signal transduction.<br />
Seminar (Host: Pr<strong>of</strong>. Dr. rer. nat. Heimo Kroemer), Department <strong>of</strong> Pharmacology,<br />
University <strong>of</strong> Greifswald, 11/1998.<br />
20. <strong>Vallon</strong> V. Tubular reabsorption: studies on the effect <strong>of</strong> angiotensin 1-7 and on its<br />
pathophysiological role in diabetes mellitus.<br />
Seminar der Disease Group Cardiovascular (Host: Priv.-Doz. Dr. rer. nat. Andreas Busch),<br />
Hoechst Marion Roussel Deutschland GmbH, Frankfurt a. M., 3/1999.<br />
21. <strong>Vallon</strong> V. Diabetic nephropathy: pathophysiological aspects and therapeutical options.<br />
Seminar (Host: Pr<strong>of</strong>. Dr. rer. nat. Ernst Schleicher), Medical Clinics, University <strong>of</strong><br />
Tübingen, 4/1999.<br />
22. <strong>Vallon</strong> V, Schnermann J. Role <strong>of</strong> aquaporin-1 in renal function: New insights derived from<br />
micropuncture studies in aquaporin-1 null mice.<br />
Seminar (Host: Josie Briggs, M.D., Mark Knepper, Ph.D.), NIDDK, National Institutes <strong>of</strong><br />
Health, Bethesda, MD, 10/1999.<br />
23. <strong>Vallon</strong> V. Glomerular hyperfiltration in diabetes mellitus: Potential role <strong>of</strong> tubular<br />
reabsorption.<br />
Molecular Physiology <strong>of</strong> Renal Sodium, Urea, and Water Transport (Host: Mark Knepper),<br />
NIDDK, National Institutes <strong>of</strong> Health, Bethesda, MD, 11/1999.<br />
24. <strong>Vallon</strong> V. Mikropuncture in mice.<br />
Seminar, Pharmacological Institute, University <strong>of</strong> Tübingen, 1/2000.<br />
25. <strong>Vallon</strong> V, Schnermann J. Macula densa-mediated reduction <strong>of</strong> nephron filtration rate in<br />
bNOS knockout mice.<br />
79. Annual Meeting German Society <strong>of</strong> Physiology, Ulm, 3/2000.
SEMINARS AND ORAL PRESENTATIONS: (continued)<br />
25<br />
V. <strong>Vallon</strong><br />
26. <strong>Vallon</strong> V, Schnermann J. Role <strong>of</strong> bNOS in macula densa: Micropuncture studies in rats<br />
and bNOS knockout mice.<br />
Seminar (Hosts: Robert Star, M.D., Josie Briggs, M.D.), NIDDK, National Institutes <strong>of</strong><br />
Health, Bethesda, MD, 4/2000.<br />
27. <strong>Vallon</strong> V. Role <strong>of</strong> potassium and potassium channels in renal function: New insights from<br />
micropuncture studies employing various potassium channel blockers.<br />
Seminar (Host: Gerhard Giebisch, M.D.), Yale University, Department <strong>of</strong> Cellular and<br />
Molecular Physiology, New Haven, CT, 4/2000.<br />
28. <strong>Vallon</strong> V, Verkman AS, Schnermann J. Luminal hypotonicity in proximal tubule and flow<br />
dependence <strong>of</strong> loop <strong>of</strong> Henle fluid absorption in aquaporin-1 knockout mice.<br />
Experimental Biology Meeting, FASEB, <strong>San</strong> Diego, CA, 4/2000.<br />
29. <strong>Vallon</strong> V. Diabetic nephropathy: pathophysiological aspects and therapeutical options.<br />
Seminar (Host: Dr. M. Schramm), Institute for Cardiovasular Research, Bayer AG,<br />
Wuppertal, 5/2000.<br />
30. <strong>Vallon</strong> V, Barhanin J, Richter K. Transport along the nephron in IsK knockout mice.<br />
Annual Meeting German Society <strong>of</strong> <strong>Nephrology</strong>, Wien, 9/2000.<br />
31. <strong>Vallon</strong> V. Control <strong>of</strong> kidney function by tubuloglomerular feedback: new insights on<br />
physiology and pathophysiology.<br />
Institute for Normal and Pathological Physiology, University <strong>of</strong> Marburg, 11/2000.<br />
32. <strong>Vallon</strong> V. Role <strong>of</strong> protein kinase C is<strong>of</strong>orms in kidney function and diabetic nephropathy.<br />
Seminar on the phenotypic analysis <strong>of</strong> protein kinase C knock-out mice.<br />
(Hosts: Dr. M. Leitges and Pr<strong>of</strong>. H. Haller), Max-Planck-Institut for Experimental<br />
Endocrinology and Medical University <strong>of</strong> Hannover, Department <strong>of</strong> <strong>Nephrology</strong>, Center for<br />
Internal Medicine, Hannover, 3/2001.<br />
33. <strong>Vallon</strong> V. Role <strong>of</strong> aquaporin-1 and KCNE1 in proximal tubule: studies in knockout mice.<br />
Seminar (Hosts: Pr<strong>of</strong>. Heini Murer and Pr<strong>of</strong>. Brigitte Kaissling), Institutes <strong>of</strong> Physiology and<br />
Anatomy, University <strong>of</strong> Zürich, 4/2001.<br />
34. <strong>Vallon</strong> V. Diabetic Nephropathie: new aspects on pathophysiology and therapy.<br />
Institute <strong>of</strong> Pharmacology, University <strong>of</strong> Heidelberg-Mannheim, 4/2001.<br />
35. <strong>Vallon</strong> V, Deng A, Bao D, Satriano J, Blantz RC,Thomson SC.<br />
Ornithine decarboxylase, kidney size, and the tubular hypothesis <strong>of</strong> glomerular<br />
hyperfiltration in experimental diabetes.<br />
Annual Meeting German Diabetes Society, Aachen, 5/2001.<br />
36. <strong>Vallon</strong> V. Pathophysiology <strong>of</strong> glomerular hyperfiltration in experimental diabetes mellitus.<br />
Annual Meeting Vascular Disease Section Tübingen, Tübingen, 6/2001.<br />
37. <strong>Vallon</strong> V. Specific rat strains and knock-out mice to delineate the pathophysiology <strong>of</strong><br />
diabetic nephropathy.<br />
Institute <strong>of</strong> Pharmacology and Toxicology, University <strong>of</strong> Tübingen, 7/2001.
SEMINARS AND ORAL PRESENTATIONS: (continued)<br />
38. <strong>Vallon</strong> V. Role <strong>of</strong> KCNQ1 and KCNE1 in kidney function.<br />
Invited Lecture. Symposium “Clinical and experimental aspects <strong>of</strong> cloned potassium<br />
channels in the kidney”<br />
(Hosts: Dr. JR Hirsch, Dr. M. Bleich) Annual Meeting <strong>of</strong> the German Society <strong>of</strong><br />
<strong>Nephrology</strong>, Münster, 9/2001.<br />
26<br />
V. <strong>Vallon</strong><br />
39. <strong>Vallon</strong> V. Role <strong>of</strong> KCNQ1 and KCNE1 in kidney function.<br />
Symposium “10 Years Department <strong>of</strong> Pharmacology University <strong>of</strong> Tübingen 1991-2001",<br />
Tübingen, 10/2001.<br />
40. <strong>Vallon</strong> V. Pathophysiology <strong>of</strong> glomerular hyperfiltration in the early phase <strong>of</strong> diabetes<br />
mellitus.<br />
Seminar (Host: Karl Hilgers, MD), University <strong>of</strong> Erlangen-Nürnberg, 11/2001.<br />
41. <strong>Vallon</strong> V. Tubulo-glomerular communication in the kidney.<br />
Institute <strong>of</strong> Physiology, University <strong>of</strong> Heidelberg, 12/2001.<br />
42. <strong>Vallon</strong> V, Wulff P, Huang DY, Völkl H, Richter K, Klingel K, L<strong>of</strong>fing J, Kauselmann G, Lang<br />
G, Kuhl D. Impaired renal Na + retention in the sgk1-knockout mouse.<br />
Invited Lecture, 81. Annual Meeting German Society <strong>of</strong> Physiology, Tübingen, 3/2002.<br />
43. <strong>Vallon</strong> V. Tubulo-glomerular feedback in the kidney: insights from transgenic mice.<br />
Invited Lecture. Pflügers Archiv International Workshop and EKRA Post-graduate course<br />
on functional genomics: "Mouse models for human diseases : a critical appraisal",<br />
(Organizers B. Rossier, E. Hummler, H. Murer, F. Lang) Tübingen, 3/2002.<br />
44. <strong>Vallon</strong> V. Regulation <strong>of</strong> renal sodium transport and blood pressure: lessons from sgk1<br />
knockout mice.<br />
Seminar (Host: Edith Sim), Department <strong>of</strong> Pharmacology, University <strong>of</strong> Oxford, 7/2002.<br />
45. <strong>Vallon</strong> V. Mechanisms <strong>of</strong> tubular sodium transport.<br />
Invited Lecture, Annual Meeting German Society <strong>of</strong> <strong>Nephrology</strong>, Düsseldorf, 9/2002.<br />
46. <strong>Vallon</strong> V, Wulff P, Huang DY, Völkl H, Richter K, Klingel K, L<strong>of</strong>fing J, Kauselmann D, Lang<br />
F, Kuhl D.<br />
Impaired renal sodium retention in the sgk1-knockout mouse.<br />
Annual Meeting Am. Soc. Nephrol., Philadelphia, PA, 10/2002.<br />
47. <strong>Vallon</strong> V. Regulation von renaler Natriumreabsorption und Blutdruck: Neue Einblicke durch<br />
Untersuchungen an SGK1-defizienten Mäusen.<br />
Seminar, Institute <strong>of</strong> Pharmacology, University <strong>of</strong> Essen, 11/2002.<br />
48. <strong>Vallon</strong> V., Huang D.Y., Gerlach U., Richter K. HMR1556, a blocker <strong>of</strong> potassium channel<br />
forming KCNQ1, inhibits glucose absorption in proximal tubule.<br />
44. Spring Meeting, German Society <strong>of</strong> Pharmacology and Toxicology, Mainz, 3/2003.<br />
49. <strong>Vallon</strong> V, Huang DY, Richter K, Schnermann J. Nephron function in adenosine A1<br />
receptor-deficient mice.<br />
Annual Meeting Am. Soc. Nephrol., <strong>San</strong> Diego, CA, 11/2003.<br />
50. <strong>Vallon</strong> V, Huang DY, Wulff P, Richter K, Kuhl D, Lang F. Effect <strong>of</strong> desoxycorticosterone<br />
acetate (DOCA) on the kidney and blood pressure in SGK1-deficient mice.<br />
Annual Meeting Am. Soc. Nephrol., <strong>San</strong> Diego, CA, 11/2003.
SEMINARS AND ORAL PRESENTATIONS: (continued)<br />
51. <strong>Vallon</strong> V. Regulation von Natriumhaushalt und Blutdruck: Bedeutung von sgk1.<br />
Institute <strong>of</strong> Pharmacology and Toxicology, University <strong>of</strong> Dresden, 3/2004.<br />
52. <strong>Vallon</strong> V. Role <strong>of</strong> sgk1 in Na + and K + homeostasis: insights from the knockout mouse.<br />
Invited Lecture, Experimental Biology Meeting, Washington D.C., 4/2004.<br />
53. <strong>Vallon</strong> V, Richter K, Huang DY, Bindels R, Hoenderop J. TRPV5 mediates Ca 2+<br />
reabsorption in distal convolution.<br />
Experimental Biology Meeting, Washington D.C., 4/2004.<br />
27<br />
V. <strong>Vallon</strong><br />
54. <strong>Vallon</strong> V. Role <strong>of</strong> sgk1 in salt and potassium homeostasis: insights from the knockout<br />
mouse.<br />
Renal Conference, <strong>Division</strong> <strong>of</strong> <strong>Nephrology</strong> & <strong>Hypertension</strong>, School <strong>of</strong> Medicine, <strong>UC</strong> <strong>San</strong><br />
Diego, 6/2004.<br />
55. <strong>Vallon</strong> V. Pathophysiologie und Pharmakologie der Niere und des Herzkreislaufsystems:<br />
Regulation von Salzhaushalt und Blutdruck durch Sgk1.<br />
Institute <strong>of</strong> Pharmacology, University <strong>of</strong> Erlangen, 8/2004.<br />
56. <strong>Vallon</strong> V, Eraly S, Richter K, Monte JC, Vaughn D, Nigam S. Role <strong>of</strong> organic anion<br />
transporter OAT3 in the natriuretic response to furosemide.<br />
46. Spring Meeting, German Society <strong>of</strong> Pharmacology and Toxicology, Mainz, 3/2005.<br />
57. <strong>Vallon</strong> V. Role <strong>of</strong> K + channel KCNQ1/KCNE1 in renal function<br />
Renal Conference, <strong>Division</strong> <strong>of</strong> <strong>Nephrology</strong> & <strong>Hypertension</strong>, School <strong>of</strong> Medicine, <strong>UC</strong> <strong>San</strong><br />
Diego, 4/2005.<br />
58. <strong>Vallon</strong> V. Role <strong>of</strong> potassium channels in electrogenic sodium reabsorption in proximal<br />
tubule.<br />
Invited Lecture, XXXV International Congress <strong>of</strong> Physiological Sciences; "Coordinating<br />
Hemodynamic, Filtration, and Reabsorptive Functions <strong>of</strong> the Kidney", <strong>San</strong> Diego, 4/2005.<br />
59. <strong>Vallon</strong> V. K + channels and transport in the kidney: insights from mice lacking<br />
KCNQ1/KCNE1, TWIK-1 or SGK1.<br />
Seminar, Yale University, Dept. <strong>of</strong> Cellular and Molecular Physiology, New Haven, 6/2005.<br />
60. <strong>Vallon</strong> V, Volkl H, Richter K, Pfeifer K. Role <strong>of</strong> K + channel KCNQ1 in electrogenic Na +<br />
reabsorption <strong>of</strong> mid to late proximal tubule.<br />
Annual Meeting Am. Soc. Nephrol., Philadelphia, PA, 11/2005.<br />
61. <strong>Vallon</strong> V. Mechanisms <strong>of</strong> distal tubular Ca 2+ reabsorption and <strong>of</strong> hypocalciuria induced by<br />
thiazides or a mouse model for Gitelman's syndrome.<br />
Renal Conference, <strong>Division</strong> <strong>of</strong> <strong>Nephrology</strong> & <strong>Hypertension</strong>, School <strong>of</strong> Medicine, <strong>UC</strong> <strong>San</strong><br />
Diego, 11/2005.<br />
62. <strong>Vallon</strong> V. Transport mechanisms along the nephron: insights from gene-targeted mice.<br />
Keynote Lecture. Annual Meeting West Coast Salt and Water Club, Morro Bay, CA,<br />
3/2006.<br />
63. <strong>Vallon</strong> V. Tackling issues <strong>of</strong> renal pharmacokinetics and pharmacodynamics by using<br />
gene-targeted mice.<br />
Seminar, Department <strong>of</strong> Pharmacology and Toxicology, University <strong>of</strong> Lausanne,<br />
Switzerland, 3/2006.
SEMINARS AND ORAL PRESENTATIONS: (continued)<br />
28<br />
V. <strong>Vallon</strong><br />
64. <strong>Vallon</strong> V. Pharmacology <strong>of</strong> the kidney – from gene to function.<br />
PRISM (Progress in the Science <strong>of</strong> Medicine)-Lecture, University <strong>of</strong> California <strong>San</strong> Diego,<br />
4/2006.<br />
65. <strong>Vallon</strong> V. SGK1 as a determinant <strong>of</strong> salt intake, blood pressure, renal damage and cardiac<br />
fibrosis in response to mineralocorticoid excess.<br />
Keynote Lecture. International Society <strong>of</strong> <strong>Hypertension</strong>, Symposium on "Aldosterone and<br />
<strong>Hypertension</strong>", Tokyo, Japan, 10/2006.<br />
66. <strong>Vallon</strong> V. Mechanisms <strong>of</strong> fluid and electrolyte transport along the nephron: lessons from<br />
genetic mouse models.<br />
Invited Lecture, Young Investigator Award, Renal Section, American Physiological Society,<br />
Experimental Biology Meeting, Washington D.C., 4/2007.<br />
67. <strong>Vallon</strong> V. Glomerular hyperfiltration and the salt paradox in early diabetes mellitus: a<br />
tubulo-centric view.<br />
Invited Lecture, World Congress <strong>of</strong> <strong>Nephrology</strong>/ISN Meeting, Rio de Janeiro 4/2007<br />
68. <strong>Vallon</strong> V. Adenosine and the kidney.<br />
Invited Lecture, Heart Failure Meeting, European Society <strong>of</strong> Cardiology, Hamburg, 6/2007.<br />
69. <strong>Vallon</strong> V. Role <strong>of</strong> SGK1 in salt and potassium homeostasis.<br />
Invited Lecture, FASEB Summer Conference, “Renal Hemodynamics – Biomolecular<br />
Control Mechanisms Integrating Vascular and Tubular Function,” Saxton’s River, VT,<br />
7/2007.<br />
70. <strong>Vallon</strong> V, Hummler E, Rieg T, Schroth J, Cheng VPC, Rossier B, Cunard R. Collecting<br />
duct-specific gene inactivation <strong>of</strong> �ENaC in the mouse kidney does not attenuate<br />
rosiglitazone-induced weight gain.<br />
Experimental Biology Meeting, <strong>San</strong> Diego, CA, 4/2008.<br />
71. <strong>Vallon</strong> V. P2Y2 receptors in the regulation <strong>of</strong> renal transport mechanisms.<br />
Invited Lecture. PURINES 2008; Copenhagen, Denmark, 6/2008.<br />
72. <strong>Vallon</strong> V. Glomerular hyperfiltration and the salt paradox in early diabetes mellitus: a<br />
tubulo-centric view.<br />
Invited Lecture. Annual Meeting German Society <strong>of</strong> <strong>Nephrology</strong>, Tuebingen, Germany,<br />
9/2008.<br />
73. <strong>Vallon</strong> V, Eraly SA, Wik<strong>of</strong>f WR, Rieg T, Kaler G, Truong DM, Ahn S-Y, Mahapatra NR,<br />
Mahata SK, Gangoiti JA, Wu W, Barshop BA, Siuzdak G, Nigam SK. Lowered blood<br />
pressure in organic anion transporter 3-null mice.<br />
Annual Meeting German Society <strong>of</strong> <strong>Nephrology</strong>, Tuebingen, Germany, 9/2008.<br />
74. <strong>Vallon</strong> V, Rieg T, Pochynyuk O, Bugaj V, Schroth J, Insel PA, Stockand J. ENaC openprobability<br />
and DOCA-induced salt-sensitivity <strong>of</strong> blood pressure are enhanced in mice<br />
lacking P2Y2 receptors.<br />
Annual Meeting German Society <strong>of</strong> <strong>Nephrology</strong>, Tuebingen, Germany, 9/2008.<br />
76. <strong>Vallon</strong> V, Hummler E, Rieg T, Pochynyuk O, Bugaj V, Schroth J, Dechenes G, Rossier B,<br />
Cunard R, Stockand J. Collecting duct-specific gene inactivation <strong>of</strong> �ENaC in the mouse kidney<br />
does not attenuate rosiglitazone-induced fluid retention<br />
Annual Meeting Am. Soc. Nephrol., Philadelphia, PA, 11/2008.
SEMINARS AND ORAL PRESENTATIONS: (continued)<br />
29<br />
V. <strong>Vallon</strong><br />
77. <strong>Vallon</strong> V, Schroth J, Satriano J, Blantz RC, Thomson SC, Rieg T. Adenosine A1 receptors<br />
are essential to glomerular hyperfiltration and the salt paradox in early streptozotocindiabetes<br />
mellitus.<br />
Annual Meeting Am. Soc. Nephrol., Philadelphia, PA, 11/2008.<br />
78. <strong>Vallon</strong> V. Regulation <strong>of</strong> renal epithelial transport by P2Y2 receptors.<br />
<strong>Division</strong> <strong>of</strong> <strong>Nephrology</strong>, University <strong>of</strong> Southern California, Los Angeles, CA, 5/2009.<br />
79. <strong>Vallon</strong> V. Regulation <strong>of</strong> epithelial sodium channel ENaC by P2Y2 receptors.<br />
Department <strong>of</strong> Medicine, University <strong>of</strong> Lübeck, Germany, 5/2009.<br />
80. <strong>Vallon</strong> V. Glomerular hyperfiltration and the salt paradox in early diabetes mellitus – a<br />
tubulocentric concept.<br />
Invited Lecture. F. H<strong>of</strong>fmann-La Roche AG, Basel, 6/2009.<br />
81. <strong>Vallon</strong> V. Physiology and pharmacology <strong>of</strong> organic anion transporters: investigations with<br />
genetically modified mouse models.<br />
Invited Lecture. Annual Meeting German Society <strong>of</strong> <strong>Nephrology</strong>, Goettingen, Germany,<br />
9/2009.<br />
82. <strong>Vallon</strong> V. Molecular determinants <strong>of</strong> renal transport: studies in gene-targeted mice.<br />
Invited Lecture. Department <strong>of</strong> Medicine, University <strong>of</strong> Erlangen-Nürnberg, Germany,<br />
9/2009.<br />
83. <strong>Vallon</strong> V. Regulation <strong>of</strong> water transport in the collecting duct: New insights from genetargeted<br />
mice.<br />
Invited Lecture, FASEB Summer Conference, “Renal Hemodynamics”, Saxton’s River, VT,<br />
6/2010.