Understanding and predicting dose dependent and idiosyncratic events
12-07-2016-1330-Paul-Watkins-YES
12-07-2016-1330-Paul-Watkins-YES
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DILSYM Modeling of AMG 853<br />
• DILIsym predicted that AMG 853 was safe in simulated<br />
humans (SimPops) although you would predict toxicity<br />
based on the BSEP Ki value…..<br />
Why? -<br />
Inhibition type was the key