memoria2015

Scientific activity
4
Strategic aims
• Detection of more polymorphisms with 250 functional
and infrequent strong effect on the population potentially
related to the development of type 2 diabetes
• Identification of different genes and polymorphisms involved
in the development of obesity through different metabolic
and functional pathways
• To determine the changes in gene expression in different
groups of patients after oral lipid overload
• To determine the relationship between different genes,
essential metals and pollutants in relation to diseases with
high cardiovascular risk
• To determine the relationship between different polymorphisms
in genes involved in the regulation of oxidative
stress and the risk of breast cancer
• To improve methodology for different genetic studies
• To develop procedures for obtaining libraries
Main lines of research
• To detect genetic changes (mutations or polymorphisms)
involved in the development of complex diseases with
high cardiovascular risk, particularly related to oxidative
stress, lipid metabolism, genes, etc.
• To study genetic variants in the exome in relation to the
development of type 2 diabetes and its consequences
• To study the importance of environmental pollutants in
the development of human diseases, mainly about heavy
metals in relation to complex diseases with high cardiovascular
risk
• PUBLICATIONS
Number of articles IF Average IF
15 51,60 3,44
National
collaborations
Original articles
International
collaborations
Corresponding
author
8 - 9
1. Suárez-Varela MM, Llopis-González A, González Albert V,
López-Izquierdo R, González-Manzano I, Chaves J, Biosca
VH, Martín-Escudero JC. Zinc and smoking habits in the
setting of hypertension in a Spanish populations.Hypertens
Res. 2015 Feb ;38(2):149-54.IF: 2,658
2. Galán-Chilet I, Guallar E, Martín-Escudero JC, De Marco G,
Dominguez-Lucas A, González-Manzano I, López-Izquierdo
R, Redon J, Chaves FJ, Téllez-Plaza M. Do genes modify the
association of selenium and lipid levels?Antioxid Redox
Signal. 2015 May 20 ;22(15):1352-62.IF: 7,407
3. Ivorra C, Fraga MF, Bayón GF, Fernández AF, García-Vicent
C, Chaves F, Redon J, Lurbe E. DNA methylation patterns in
newborns exposed to tobacco in utero.J Transl Med. 2015
Jan 27 ;13(1):25.IF: 3,93
4. Martínez-Barquero V, de Marco G, Martínez-Hervas S, Rentero
P, Galán-Chilet I, Blesa S, Morchon D, Morcillo S, Rojo
G, Ascaso JF, Real JT, Martín-Escudero JC, Chaves FJ. Polymorphisms
in endothelin system genes, arsenic levels and
obesity risk.PLoS One. 2015 ;10(3):e0118471.IF: 3,234
5. Morales-Suárez-Varela M, Llopis-González A, González-
Albert V, López-Izquierdo R, González-Manzano I, Chaves
J, Huerta-Biosca V, Martín-Escudero JC. Correlation of zinc
with oxidative stress biomarkers.Int J Environ Res Public
Health. 2015 Mar 12 ;12(3):3060-76.IF: 0
6. Llopis-González A, Rubio-López N, Pineda-Alonso M, Martín-
Escudero JC, Chaves FJ, Redondo M, Morales-Suárez-Varela
M. Hypertension and the fat-soluble vitamins A, D and E.Int J
Environ Res Public Health. 2015 Mar 4 ;12(3):2793-809.IF: 0
7. Alonso R, Salavert F, García-García F, Carbonell-Caballero
J, Bleda M, García-Alonso L, Sanchís-Juan A, Perez-Gil D,
Marin-García P, Sanchez R, Cubuk C, Hidalgo MR, Amadoz A,
Hernansaiz-Ballesteros RD, Alemán A, Tarraga J, Montaner
D, Medina I, Dopazo J. Babelomics 5.0: functional interpretation
for new generations of genomic data.Nucleic Acids
Res. 2015 Jul 1 ;43(W1):W117-21.IF: 9,112
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