memoria2015
memoria2015
memoria2015
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Scientific activity<br />
4<br />
Strategic aims<br />
• Publication of the results obtained by modifying the electrophysiological<br />
effects of myocardial stretching by EIPA, losartan,<br />
BQ-123, and ranolazine<br />
• Continuation of the experimental series to analyze the<br />
effects of JTV519, KN-93, Carvedilol and analogues<br />
• Continuation of the analysis of the effects of modifications<br />
of the basic electrophysiological properties on the processes<br />
involved in the initiation, perpetuation and the cessation of<br />
ventricular fibrillation<br />
• It has continued the analysis of the electrophysiological<br />
effects of chronic physical exercise and its protective effect<br />
against arrhythmias, the influence of the cardiac nervous<br />
system and mitochondrial oxidative stress and the involvement<br />
of the IKATP current<br />
• Development of instruments for recording, processing and<br />
analysis of cardiac electrophysiological signals obtained with<br />
mapping systems<br />
• Home of the research aimed to study the mechanisms involved<br />
in the deterioration of the systolic function, fibrosis and<br />
the inducibility of arrhythmias in a chronic model of infarction<br />
in rabbit hearts<br />
Main lines of research<br />
• Myocardial stress: analysis of electrophysiological changes<br />
induced by mechanical stretching. Autocrine/paracrine infuences<br />
and study of protective actions by means of drugs<br />
• Clinical and basic research on heart failure: role of calcium<br />
homeostasis in arrhythmogenesis. Study on the effects of<br />
drugs acting on intracellular Ca 2+ dynamics<br />
• Analysis of the effects of modifications in basic electrophysiological<br />
properties on the processes involved in beginning,<br />
perpetuation and cessation of ventricular fibrillation<br />
• Study of electrophysiological effects of chronic physical activity<br />
by: a) analysis of the protection against arrhythmias or<br />
scientific activity facilitation of its reversion; b) study of the<br />
influence of heart’s nervous system and mitochondrial oxidative<br />
stress; and c) analysis of the effects on the electrical<br />
instability induced by myocardial ischemia and the implication<br />
of IKATP current<br />
• Development and extension of tools for the registration,<br />
processing and analysis of cardiac electrophysical signals based<br />
on multielectrodes and optical cartography systems able<br />
to analyze voltage and calcium signals<br />
• Study the mechanisms involved in the deterioration of the<br />
systolic function, fibrosis and the inducibility of arrhythmias<br />
in a chronic model of infarction in rabbit hearts<br />
• PUBLICATIONS<br />
Number of articles IF Average IF<br />
25 67,76 2,71<br />
National<br />
collaborations<br />
Original articles<br />
International<br />
collaborations<br />
Corresponding<br />
author<br />
16 4 12<br />
1. Del-Canto I, López-Lereu MP, Monmeneu JV, Croisille P,<br />
Clarysse P, Chorro FJ, Bodí V, Moratal D. Characterization of<br />
normal regional myocardial function by MRI cardiac tagging.J<br />
Magn Reson Imaging. 2015 Jan ;41(1):83-92.IF: 3,21<br />
2. Villanueva MP, Mollar A, Palau P, Carratalá A, Núñez E,<br />
Santas E, Bodí V, Chorro FJ, Miñana G, Blasco ML, Sanchís<br />
J, Núñez J. Procalcitonin and long-term prognosis after an<br />
admission for acute heart failure.Eur J Intern Med. 2015 Jan<br />
;26(1):42-8.IF: 2,891<br />
3. Serra-Añó P, Montesinos LL, Morales J, López-Bueno<br />
L, Gomis M, García-Massó X, González LM. Heart rate<br />
variability in individuals with thoracic spinal cord injury.<br />
Spinal Cord. 2015 Jan ;53(1):59-63.IF: 1,804<br />
4. Filgueiras-Rama D, Calvo CJ, Salvador-Montañés Ó, Cádenas<br />
R, Ruiz-Cantador J, Armada E, Rey JR, Merino JL, Peinado<br />
R, Pérez-Castellano N, Pérez-Villacastín J, Quintanilla<br />
JG, Jiménez S, Castells F, Chorro FJ, López-Sendón JL,<br />
Berenfeld O, Jalife J, de Sá EL, Millet J. Spectral analysisbased<br />
risk score enables early prediction of mortality and<br />
cerebral performance in patients undergoing therapeutic<br />
hypothermia for ventricular fibrillation and comatose<br />
status.Int J Cardiol. 2015 Mar 14 ;186:250-258.IF: 4,036<br />
5. Santas E, Chorro FJ, Miñana G, Méndez J, Muñoz J, Escribano<br />
D, García-Blas S, Valero E, Bodí V, Núñez E, Sanchís J, Núñez<br />
J. Tricuspid Regurgitation and Mortality Risk Across Left<br />
Ventricular Systolic Function in Acute Heart Failure.Circ J.<br />
2015 ;79(7):1526-33.IF: 3,94<br />
6. Chorro FJ, Canto ID, Brines L, Such-Miquel L, Calvo C, Soler<br />
C, Zarzoso M, Trapero I, Tormos Á, Such L. Experimental<br />
51
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