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REDUCING DRUG MANUFACTURING COSTS Strand 3: Drug Product Formulation The focus of Strand 3 research is on bringing stronger scientific and process engineering principles and knowledge into the domain of Solid State Pharmaceutics, which up to now has essentially been empiric. This improved approach is demanded by the Quality by Design knowledge-based approach to develop new products and formulations. MAJOR THEMES INCLUDE: • Understanding the nature and strength of interactions between APIs and excipients. • Identification of currently unknown critical attributes in APIs and excipients that lead to failures during formulation. • Development of new materials and technologies for the generation and stabilisation of the amorphous state, which is one approach to realising the potential of BSC Class II poorly soluble drugs. 14
Butyl paraben crystals grown from acetonitrile solution BY DR LIJUN JIA, <strong>SSPC</strong>
Page 1: molecule material medicine
Page 5 and 6: CONTENTS P2 NEXT GENERATION DRUG MA
Page 7 and 8: SSPC IN NUMBERS €44 MILLION INVES
Page 9 and 10: Europe BELGIUM FRANCE ITALY NETHERL
Page 11 and 12: Pharmaceutical manufacturing contri
Page 13 and 14: “ The SSPC aims to deliver indust
Page 15 and 16: Trust, a culture of inclusivity and
Page 17 and 18: BUILDING A STRONG PHARMACEUTICAL CO
Page 19 and 20: synthesis “ Bold, Ambitious, Wide
Page 21: DEVELOPING MORE ENVIRONMENTALLY SUS
Page 25 and 26: “ This research generates signifi
Page 27 and 28: Professor Kieran Hodnett SSPC SCIEN
Page 29 and 30: Professor Brian Glennon STRAND 2 LE
Page 31 and 32: Funded Investigators (contd.) Title
Page 33 and 34: THE SSPC IS DEDICATED TO OBTAINING
Page 35 and 36: The SSPC is tasked with delivering
Page 38 and 39: CONTACT US www.sspc.ie/contact_sspc

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