Management of DAAs Failure
If you have failure of plan A in treating a patient with chronic hepatitis C. What's your plan B
If you have failure of plan A in treating a patient with chronic hepatitis C. What's your plan B
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SVR12 (%)<br />
24 Wks <strong>of</strong> LDV/SOF Retreatment After <strong>Failure</strong> <strong>of</strong> 8-12 Wks <strong>of</strong><br />
LDV/SOF-Based Tx<br />
• GT1 HCV–infected pts with and without cirrhosis previously treated with 8 or 12 wks <strong>of</strong> LDV/SOF ± RBV<br />
100<br />
100<br />
80<br />
60<br />
71 68<br />
74<br />
80<br />
46<br />
60<br />
40<br />
n/N =<br />
20<br />
0<br />
29/<br />
41<br />
Lawitz E, et al. EASL 2015. Abstract O005.<br />
15/<br />
22<br />
14/<br />
19<br />
All No Yes<br />
Cirrhosis<br />
24/<br />
30<br />
5/<br />
11<br />
8 Wks 12 Wks<br />
Previous Tx<br />
Duration<br />
11/<br />
11<br />
No<br />
18/<br />
30<br />
Yes<br />
BL NS5A RAVs
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