Management of DAAs Failure
If you have failure of plan A in treating a patient with chronic hepatitis C. What's your plan B
If you have failure of plan A in treating a patient with chronic hepatitis C. What's your plan B
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Treatment recommendations for retreatment <strong>of</strong><br />
HCV who failed to achieve SVR on prior antiviral<br />
therapy containing one or several <strong>DAAs</strong><br />
‡<br />
‡<br />
Patients who failed to achieve SVR with a PegIFN-α and telaprevir, or boceprevir, or simeprevir<br />
GT1<br />
LDV/SOF<br />
12 weeks +<br />
RBV<br />
SOF/VEL<br />
12 weeks +<br />
RBV<br />
OBV/PTV/<br />
RTV + DSV<br />
OBV/PTV/<br />
RTV<br />
- - -<br />
GZR/EBR SOF + DCV SOF + SMV<br />
12 weeks<br />
+ RBV<br />
-<br />
Patients who failed to achieve SVR with a SOF + SMV<br />
LDV/SOF<br />
SOF/VEL<br />
OBV/PTV/<br />
RTV + DSV<br />
OBV/PTV/<br />
RTV<br />
GZR/EBR SOF + DCV SOF + SMV<br />
GT1<br />
or<br />
GT4<br />
12 weeks +<br />
RBV (F0-F2)<br />
or<br />
24 weeks +<br />
RBV (F3-F4)<br />
12 weeks +<br />
RBV (F0-F2)<br />
or<br />
24 weeks +<br />
RBV (F3-F4)<br />
- - -<br />
12 weeks + RBV<br />
(F0-F2) or<br />
24 weeks + RBV<br />
(F3-F4)<br />
-<br />
•EASL Recommendations on Treatment <strong>of</strong> Hepatitis C 2016; Journal <strong>of</strong> Hepatology 2016<br />
http://dx.doi.org/10.1016/j.jhep.2016.09.001 (Accessed September 2016)
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