"Blood Substitutes"(Milligan)
"Blood Substitutes"(Milligan)
"Blood Substitutes"(Milligan)
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Conjugated HBOCs<br />
• PEG-Hemoglobin (Enzon) – polyethylene glycol conjugated to<br />
bovine Hb tetramer<br />
Much larger molecular radius<br />
Longer T1/2 than most HBOCs (48h)<br />
Hyperoncotic<br />
Used as sensitized for radiation treatment of solid tumours<br />
• PHP (Apex Bioscience) – pyridoxilation of human Hb followed by<br />
conjugation with polyoxyethylene<br />
Hypertensive effects<br />
Phase III trials in septic & hemorrhagic shock<br />
• Hemospan (Sangart) – human Hb tetramer conjugated to<br />
polyethylene glycol<br />
Larger molecular diameter, high viscosity & high O2 affinity to<br />
minimize autoregulatory & vasoconstrictive effects<br />
Phase III trials
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