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"Blood Substitutes"(Milligan)

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Research Developments<br />

• Hemoglobin from worms: Lumbricus<br />

terrestris, Arenicola marina<br />

• Hb polymers, 50x larger than human<br />

• No modification required to remain<br />

stable in bloodstream long enough<br />

to oxygenate tissues<br />

• No breakdown and kidney damage<br />

• Pre-clinical testing in mice: normal<br />

O2 carrying capacity & no allergic<br />

reactions<br />

• ?ease of extraction & purification in<br />

sufficient quantities<br />

• ?hypertension

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