"Blood Substitutes"(Milligan)

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How would a blood substitute be used? • Coupling with autologous blood • Supporting transfusion service in developing countries • Battlefield or natural disasters • Alternative to blood transfusion for patients with religious objections
Properties of an “ideal” blood substitute • Adequate oxygen uptake in the lungs • Adequate oxygen delivery to the tissues • Long circulation time • Non-toxic • Rapidly excreted without causing harm • Stable at room temperature • Easily sterilized • Cheap to manufacture • Long shelf-life & easy to store • Widely applicable w/o cross-matching • Free of side-effects
Page 1 and 2: BLOOD SUBSTITUTES By Lisa Milligan
Page 3 and 4: Problems associated with blood tran
Page 5: Blood Substitutes Blood substitutes
Page 9 and 10: Types of Blood Substitutes
Page 11 and 12: O2 Delivery by hemoglobin
Page 13 and 14: Cell-free hemoglobin
Page 15 and 16: Size • 64 kDa Hb tetramer dissoci
Page 17 and 18: Vasoactivity • Many HBOCs have sy
Page 19 and 20: Oxidation • In RBC Hb protected f
Page 21 and 22: Modified - hemoglobins
Page 23 and 24: Polymerized HBOCs • PolyHeme (Nor
Page 25 and 26: Perfluorocarbon - based substitutes
Page 27 and 28: Perfluorocarbons • Synthetic liqu
Page 29 and 30: Microvascular effects of PFCs • E
Page 31 and 32: Perfluorocarbon products • Fluoso
Page 33 and 34: Research Developments • Hemoglobi

"Blood Substitutes"(Milligan)

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