Bacterial Meningitis
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General Microscopic<br />
Description<br />
• In acute purulent meningitis, the subarachnoid space is filled<br />
with neutrophils and bacteria with increasing numbers of<br />
macrophages and lymphocytes over time.<br />
• The underlying brain is usually protected by the pia so that<br />
there is no intracerebral inflammation, however, the cortex<br />
and white matter will show spongy change or vacuolization<br />
due to edema.<br />
• Infants more often show bacteria and neutrophils invading the<br />
underlying parenchyma.
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